Clinical Features of Acute Respiratory Viral Infections in Infants with Thymomegaly

Authors

  • T.V. Sorokman Bukovinian State Medical University, Chernivtsi
  • S.V. Sokolnyk Bukovinian State Medical University, Chernivtsi
  • M.I. Polishchuk Bukovinian State Medical University, Chernivtsi
  • O.-M.V. Popeliuk Bukovinian State Medical University, Chernivtsi

DOI:

https://doi.org/10.22141/2224-0551.1.69.2016.73701

Keywords:

acute respiratory viral infections, children, thymomegaly

Abstract

Introduction. Peculiarities of acute respiratory viral infections (ARVI) in children with increased size of the thymus are associated with the presence of more or less significant immunodeficiency and dyshormonosis with manifestations of adrenal insufficiency. Objective — to study the features of acute respiratory viral infections and to investigate adrenal function in infants with thymomegaly. Material and methods. 41 children aged 1 month to 3 years with thymomegaly and complicated forms of ARVI were involved in clinical studies. Etiological decoding of ARVI has been carried out with the use of paired serum samples. The content of cortisol in the blood plasma was determined by immunoenzyme method. 36 children with thymomegaly without ARVI manifestations within at least 3 months were in comparison group. Results. Analysis of the anamnesis in patients with thymomegaly showed that most of them experienced adverse conditions at different stages of antenatal, intrapartum and postnatal development. Analysis of the data on the size of the thymus gland showed that 3rd — 4th degree of thymomegaly is often observed in children with signs of constrictive laryngotracheitis (75.0 %). 23.5 % of patients with obstructive bronchitis had 1st degree thymomegaly, the rest — 3rd and 4th degrees. In case of nonobstructive lesions of the bronchi, the opposite trend took place: the least degree of thymomegaly was diagnosed in 62.5 %, and 3rd and 4th — in 37.5 % (p < 0.05) of patients. The lowest supply of cortisol was noted in the acute period of constrictive laryngotracheitis (409.4 ± 10.2 nmol/ml against 537.7 ± 11.5 nmol/ml in the comparison group; p < 0.05). In the acute period of ARVI complicated by bronchitis, cortisol levels were not increased — 432.3 ± 32.3 nmol/ml. In the group of patients with pneumonia, we have recorded reliable, probably compensatory increase of cortisol level (787.3 ± 2.0 nmol/ml, p < 0.05). In the acute period of obstructive bronchitis, only tendency towards increasing of cortisol concentration in the blood (562.9 ± 18.9 nmol/ml)
was observed. Restoration of adrenocortical function during recovery of infants with thymomegaly was inhomogeneous too. Parameters of children who recovered from acute bronchitis were most significantly closer to physiological parameters. Cortisol supply in patients with pneumonia at the time of recovery did not differ from baseline in children with thymomegaly. The amount of cortisol increased fastest in the dynamics of constrictive laryngotracheitis (up to 528.5 ± 22.6 nmol/ml). Conclusion. Children with thymomegaly are at risk for the development of bronchopulmonary complications of acute respiratory viral infections.

Downloads

Download data is not yet available.

References

Dynamics of cytokines in infants with acute obstructive bronchitis on the background thymomegaly / Smiyan O.I. [ta in.] // Likars'ka sprava. - 2015. - N 1/2. - S. 81-85.

Kuz'menko L.H. Malignant neoplasms of children in families with different values of the thymus / L. H. Kuz'menko // Pedyatryya. Zhurn. ym. H.N. Speranskoho. - 2011. -Tom 90,N 4. - S. 53-60.

Lytvynenko D. V. Thymomegaly in children, sudden death syndrome and neonatal Platter as a transient immune markers, current approaches to diagnosis and treatment / D. V. Lytvynenko, M. I. Slychko, E. A. Levyts'kyy // Ukr. nauk.-med. molodizhnyy zhurnal. - 2015. - Spets. vыp. 1. - S. 41-43.

Syrotyna O.B. Ultrasound examination of the thymus in normal children at some diseases and conditions / O. B. Syrotyna // Mizhnar. endokrynol. zhurnal. - 2012. -N 1. - S. 76-86.

Furman I.M. Features of clinical course of acute respiratory viral infections in young children with thymomegaly. Risk factors / I.M. Furman, T.M. Lytvynenko, K.A. Dyedkova; Nauk. ker. P.I. Sichnenko // Aktual'ni pytannya teoretychnoyi ta praktychnoyi medytsyny : zbirnyk tez dopovidey II Mizhnarodnoyi naukovo-praktychnoyi konferentsiyi studentiv ta molodykh vchenykh, m. Sumy, 16-18 kvitnya 2014 r. / M.V. Pohoryelov. - Sumy : SumDU, 2014. - S. 205-206.

Published

2021-09-22

How to Cite

Sorokman, T., Sokolnyk, S., Polishchuk, M., & Popeliuk, O.-M. (2021). Clinical Features of Acute Respiratory Viral Infections in Infants with Thymomegaly. CHILD`S HEALTH, (1.69), 34–38. https://doi.org/10.22141/2224-0551.1.69.2016.73701

Issue

Section

Clinical Pediatrics

Most read articles by the same author(s)

1 2 3 4 5 > >>