Transient Neonatal Diabetes Associated with Imprinting Disorders in 6Q24 Chromosome Part 1. Іmprinted Cluster PLAGL1/HYMAI

Authors

  • A.Ye. Abaturov SI «Dnipropetrovsk Medical Academy of Ministry of Health of Ukraine» http://orcid.org/0000-0001-6291-5386
  • Ye.A. Agafonova SI «Dnipropetrovsk Medical Academy of Ministry of Health of Ukraine»
  • V.L. Babich SI «Dnipropetrovsk Medical Academy of Ministry of Health of Ukraine»

DOI:

https://doi.org/10.22141/2224-0551.8.68.2015.75187

Keywords:

cluster of imprinted PLAGL1/HYMAI

Abstract

The article presents modern data on the mechanisms of genetic disorders that lead to the development of neonatal diabetes mellitus associated with the violation of imprin­ting of 6q24 chromosome. This article contains information about the structure of the imprinted cluster PLAGL1/HYMAI, gene and protein PLAGL1 ZAC1, non-coding RNAs and ­HYMAI ZAC-AS, the differentially methylated area PLAGL1/HYMAI cluster. It is shown that the cluster ICR PLAGL1/HYMAI hypermethylation is accompanied with PLAGL1 gene transcriptional silencing in cells of various human malignancies, including ovarian cancer, colorectal cancer, sarcoma, glioblastoma and rhabdomyosarcoma, and hypomethylation is associated with transient neonatal diabetes mellitus.

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References

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Published

2022-01-19

How to Cite

Abaturov, A., Agafonova, Y., & Babich, V. (2022). Transient Neonatal Diabetes Associated with Imprinting Disorders in 6Q24 Chromosome Part 1. Іmprinted Cluster PLAGL1/HYMAI. CHILD`S HEALTH, (8.68), 56–61. https://doi.org/10.22141/2224-0551.8.68.2015.75187

Issue

Section

To Help the Pediatrician

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