The results of prospective multicenter study of the effectiveness of amino acid formula in infants with severe atopic dermatitis and allergy to cow’s milk proteins

Authors

  • S.L. Nyankovskyy Danylo Halytsky Lviv National Medical University
  • O.G. Shadrin State Institution «Institute of Pediatrics, Obstetrics and Gynecology of National Academy of Medical Sciences of Ukraine», Kyiv
  • V.A. Klimenko Kharkiv National Medical University
  • D.O. Dobryanskyy Danylo Halytsky Lviv National Medical University
  • M.S. Iatsula Danylo Halytsky Lviv National Medical University
  • O.S. Ivakhnenko Danylo Halytsky Lviv National Medical University
  • S.M. Nedelska Zaporizhzhia State Medical University
  • T.V. Kobets Crimea State Medical University
  • O.M. Ashcheulov Kharkiv National Medical University
  • H.A. Haiduchyk State Institution «Institute of Pediatrics, Obstetrics and Gynecology of National Academy of Medical Sciences of Ukraine», Kyiv
  • O.P. Paholchuk Zaporizhzhia State Medical University
  • O.V. Hostishcheva Crimea State Medical University

DOI:

https://doi.org/10.22141/2224-0551.4.55.2014.76160

Keywords:

infants, food allergy, amino acid formula, atopic dermatitis, diet therapy

Abstract

The article presents the main results of prospective multicenter study of effectiveness of using amino acid formula in diet therapy for the infants with severe atopic dermatitis (AD) and allergy to cow's milk protein (CMP). The study was conducted in 5 centers of Ukraine and included 30 infants with severe atopic dermatitis (EASI score > 18) aged from 29 days to 11 months. 22 patients completed the study. Diet therapy considered administration of amino acid formula containing 100 % free amino acids, for 4 weeks. Evaluation of clinical effectiveness of AD and allergy to CMP diet therapy with amino acid formula was carried out on the 7th, 14th and 28th day after reaching the full daily volume of the formula. Provocative test was performed on the 28th day with extensively hydrolyzed whey protein formula followed with evaluation of immediate and late reactions.
Infants with severe AD (EASI score > 18) were characterized by impairment of several organs and systems: in 68 % of cases skin symptoms were associated with the gastrointestinal signs like change in stool frequency (constipation, diarrhea), appearance of pathological admixtures in feces (mucus, blood), vomiting, and others. With administration of amino acid formula significant decrease in severity of skin (98 %) and gastro-intestinal manifestations of food allergy (82 %) were seen.
Amino acid formula was well tolerated by children with severe AD and, if needed, it might be used as a therapeutic formula for an exclusive feeding of infants with severe allergies to CMP. Duration of the diet therapy should not be less than 4 weeks. High effectiveness of this formula in infants with AD was proved by parents and doctors.

Downloads

Download data is not yet available.

References

Недельська С.М. Раціональне харчування в профілактиці та лікуванні алергії на їжу у дітей / С.М. Недельська, О.П. Пахольчук, Т.Г. Бессікало // Современная педиатрия. — 2012. — № 6. — С. 113-114.

Няньковский С.Л., Кліменко В.А., Івахненко О.С. Харчова алергія на білок коров’ячого молока у дітей раннього віку з позиції лікаря-педіатра // Здоровье ребенка. — 2012. — № 6 (41). — С. 159-166.

Hill D.J., Firer M.A., Shelton M.J., Hosking C.S. Manifestations of milk allergy in infancy: clinical and immunologic findings // J. Pediatr. — 1986. — Vol. 109. — Р. 270-276.

Allen K. Management of cow’s milk protein allergy in infants and young children: an expert panel perspective / Allen K., Davidson G., Day A., Hill D., Kemp A., Peake J., Prescott S., Shugg A., Sinn J., Heine R. // J. Paediatr. Child. Health. — 2009. — Vol. 45. — P. 481-486.

Boyce J. Guidelines for the diagnosis and management of food allergy in the United States: report of the NIAID-sponsored expert panel / Boyce J., Assa’ad A., Burks A., Jones S., Sampson H., Wood R., Plaut M., Cooper S., Fenton M., Arshad S., Bahna S., Beck L., Byrd-Bredbenner C., Camargo C., Eichenfield L., Furuta G., Hanifin J., Jones C., Kraft M., Levy B., Lieberman P., Luccioli S., McCall K., Schneider L., Simon R., Simons F., Teach S., Yawn B., Schwa­ninger J. // J. Allergy Clin. Immunol. — 2010. — Vol. 126. — S1-58.

Caffarelli C. EWGPAG. Cow’s milk protein allergy in children: a practical guide / Caffarelli C., Baldi F., Bendandi B., Calzone L., Marani M., Pasquinelli P. // Ital. J. Pediatr. — 2010. — Vol. 15. — P. 36-45.

Wood R.A. The natural history of food allergy // Pediatrics. — 2003. — Vol. 111. — P. 1631-1637.

Host A. Clinical course of cow’s milk protein allergy/intolerance and atopic diseases in childhood / Host A., Halken S., Jacobsen H.P., Christensen A.E., Herskind A.M., Plesner K. // Pediatr. Allergy Immunol. — 2002. — Vol. 13. — P. 23-28.

Miyazawa T., Itahashi K., Imai T. Management of neonatal cow’s milk allergy in high-risk neonates // Pediatr. Int. — 2009. — Vol. 51. — P. 544-547.

Brugman E. / Brugman E., Meulmeester J.F., Speevan der W.A., Beuker R.J., Radder J.J., Verloove-Vanhorick S.P. Prevalence of self-reported food hypersensitivity among school children in The Netherlands // Eur. J. Clin. Nutr. — 1998. — Vol. 52. — P. 577-581.

Eggesbo M., Botten G., Halvorsen R., Magnus P. The prevalence of allergy to egg: a population-based study in young children // Allergy. — 2001. — Vol. 56. — P. 403-411.

Halmerbauer G. Study on the Prevention of Allergy in Children in Europe (SPACE): Allergic sensitization in children at 1 year of age in a controlled trial of allergen avoidance from birth / Hal­merbauer G., Gartner C., Schierl M., Arshad H., Dean T. // Pediatr. Allergy Immunol. — 2002. — Vol. 13. — P. 47-54.

Bock S.A. Prospective appraisal of complaints of adverse reactions to foods in children during the first three years of life // Pediatrics. — 1987. — Vol. 79. — P. 683-688.

Höst A. Clinical course of cow’s milk protein allergy/intolerance and atopic diseases in childhood / Höst A., Halken S., Jacobsen H.P., Christensen A.E., Herskind A.M., Plesner K. // Pediatr. Allergy Immunol. — 2002. — Vol. 13(Suppl. 15). — P. 23-28.

Saarinen K. Supplementary feeding in maternity hospitals and the risk of cow’s milk allergy: a prospective study of 6209 infants / Saarinen K., Juntunen-Backman K, Järvenpää A., Kuitunen P., Lope L., Renlund M., Siivola M., Savilahti E. // J. Allergy Clin. Immunol. — 1999. — Vol. 104. — P. 457-461.

Kvenshagen B, Halvorsen R, Jacobsen M. Adverse reactions to milk i infants // Acta Paediatr. — 2008. — 97. — 196-200.

Venter C., Pereira B., Grundy J., Clayton C.B., Roberts G., Higgins B., Dean T. Incidence of parentally reported and clinically diagnosed food hypersensitivity in the first year of life // J. Allergy Clin. Immunol. — 2006. — Vol. 117. — P. 1118-1124.

Schrander J., Van Den Bogart J. Cow’s milk protein intolerance i infants under 1 year of age: a prospective epidemiological study // Eur. J. Pediatr. — 1993. — Vol. 152. — P. 640-644.

Fiocchi A. World Allergy Organization (WAO) Special Committee on Food Allergy. World Allergy Organization (WAO) Diagnosis and Rationale for Action against Cow’s Milk Allergy (DRACMA) Guidelines / Fiocchi A., Brozek J., Schünemann H., Bahna S.L., von Berg A., Beyer K., Bozzola M., Bradsher J., Compalati E., Ebisawa M., Guzmán M.A., Li H., Heine R.G., Keith P., Lack G., Landi M., Martelli A., Rancé F., Sampson H., Stein A., Terracciano L., Vieths S. // Pediatr. Allergy. Immunol. — 2010. — Vol. 21, Suppl. 21. — P. 1-125.

Шадрін О.Г. Рекомендації щодо ведення дітей із харчовою алергією до білка коров’ячого молока / Шадрін О.Г., Няньковський С.Л., Уманець Т.Р., Клименко В.А., Добрянський Д.О., Івахненко О.С., Яцула М.С., Гайдучик Г.А. // Дитячий лікар. — 2012. — № 7. — С. 27-42.

Казначеева Л.Ф., Ишкова Н.С., Казначеев К.С., Дубровина Л.Н., Геращенко Н.В. Опыт применения смесей на основе аминокислот у детей с пищевой аллергией // Педиатрия. — 2013. — Том 92, № 4. — С. 92-96.

Пампура А.Н. Эффективность аминокислотной смеси при тяжелом атопическом дерматите у детей первого года жизни: результаты открытого многоцентрового проспективного исследования / Пампура А.Н., Лаврова Т.Е., Тренева М.С., Таран Н.Н., Филатова Т.А. // Российский вестник перинатологии и педиатрии. — 2013. — № 1. — С. 93-100.

Vanderhoof J.A., Murray N.D., Kaufman S.S. et al. Intolerance to protein hydrolysate infant formulas: an under recognized cause of gastrointestinal symptoms in infants // J. Pediatr. — 1997. — Vol. 131. — P. 741-744.

Hill D., Heine R., Cameron D. et al. The natural history of intolerance to soy and extensively hydrolyzed formula in infants with multiple food protein intolerance // J. Pediatr. — 1999. — Vol. 135. — P. 118-121.

Estep D., Kulczycki A. Treatment of infant colic with amino acid-based infant formula: a preliminary study // Acta Paediatr. — 2000. — Vol. 89. — P. 22-27.

Hill D., Heine R., Cameron D. et al. Role of food protein intolerance in infants with persistent distress attributed to reflux esophagitis // J. Pediatr. — 2000. — Vol. 136. — P. 641-647.

Niggemann B., Binder C., Dupont C. et al. Prospective, controlled, multi-center study on the effect of an amino-acid-based formula in infants with cow’s milk allergy/intolerance and atopic dermatitis // Pediatr. Allergy Immunol. — 2001. — Vol. 12. — P. 78-82.

Published

2022-02-24

How to Cite

Nyankovskyy, S., Shadrin, O., Klimenko, V., Dobryanskyy, D., Iatsula, M., Ivakhnenko, O., Nedelska, S., Kobets, T., Ashcheulov, O., Haiduchyk, H., Paholchuk, O., & Hostishcheva, O. (2022). The results of prospective multicenter study of the effectiveness of amino acid formula in infants with severe atopic dermatitis and allergy to cow’s milk proteins. CHILD`S HEALTH, (4.55), 43–50. https://doi.org/10.22141/2224-0551.4.55.2014.76160

Issue

Section

Clinical Pediatrics

Most read articles by the same author(s)

1 2 3 4 5 6 7 > >>