Chronic Granulomatous Disease: the Experience of Diagnosis and Treatment in Children

Authors

  • L.I. Chernyshova National Medical Academy of Postgraduate Education named after P.L. Shupyk http://orcid.org/0000-0002-9980-250X
  • A.P. Volokha National Medical Academy of Postgraduate Education named after P.L. Shupyk
  • A.V. Bondarenko National Medical Academy of Postgraduate Education named after P.L. Shupyk
  • A.M. Gilfanova National Medical Academy of Postgraduate Education named after P.L. Shupyk
  • V.P. Chernyshov State Institution «Institute of Pediatrics, Obstetrics and Gynecology of National Academy of Medical Sciences of Ukraine», Kyiv

DOI:

https://doi.org/10.22141/2224-0551.4.47.2013.89801

Keywords:

chronic granulomatous disease, primary immune deficiency, children

Abstract

Chronic granulomatous disease — primary immunodeficiency with X-linked and autosomal recessive inheritance, characterized by impaired bactericidal function of phagocytic immune system. Chronic granulomatous disease is accompanied by the development of severe bacterial and fungal infections of the skin, lymph nodes, lungs, liver, and excessive inflammation with granuloma formation. For the first time in Ukraine the paper describes cases of chronic granulomatous disease in children with a characteristic clinical phenotype in the form of severe bacterial infections with the lesion of the different organs and systems, the manifestation in the first months of life. We should note patients’ predisposition to mycobacterial infection, caused both by typical Mycobacterium tuberculosis, and atypical mycobacteria, including Mycobacterium bovis, BCG strain. Now the question of early diagnosis and optimization of treatment of chronic granulomatous disease in Ukraine remaines extremely topical.

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References

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Published

2022-02-25

How to Cite

Chernyshova, L., Volokha, A., Bondarenko, A., Gilfanova, A., & Chernyshov, V. (2022). Chronic Granulomatous Disease: the Experience of Diagnosis and Treatment in Children. CHILD`S HEALTH, (4.47), 60–66. https://doi.org/10.22141/2224-0551.4.47.2013.89801

Issue

Section

To Help the Pediatrician

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