Guillain — Barré syndrome following asymptomatic COVID-19 in an adolescent: a clinical case




Guillain — Barré syndrome, polyneuropathy, children, COVID-19


Guillain — Barré syndrome (GBS) is a rare di­­sease that occurs with an approximate incidence of 1.7 cases per 100,000 children in the pediatric population. The gender difference in the prevalence of the disease is characterized by a 20% greater vulnerability of boys than girls. The exact cause of Guillain — Barre syndrome is unknown; however, it can occur after respiratory infection by Haemophilus influenzae, recent or ongoing Campylobacter jejuni infection or poliovirus. Since the beginning of the COVID-19 pandemic, there have been some reported Guillain — Barré diagnoses among adults following SARS-CoV-2 infection. The article describes a clinical case of an adolescent girl who was admitted to the Regional Municipal Non-Profit Facility “Chernivtsi Regional Children’s Clinical Hospital” with signs of flaccid paraplegia of the lower extremities, pelvic dysfunction and paraparesis of the upper extremities after she had suffered a sudden severe pain syndrome. She had previously been diagnosed with asymptomatic SARS-CoV-2. Initial complex investigations were as follows: high white blood cells count, elevated levels of procalcitonin (PCT), C-reactive protein and D-dimer, low SARS-CoV-2 IgM level and positive IgG titer, high levels of protein in spinal fluid. Electroneuromyography findings and nerve conduction test of lower extremities showed decreased M amplitude and H reflex response. The patient received oxygen therapy, hemodynamic support, cardiac support (infusions and inotrope therapy), gradual antibacterial therapy and was administrated with intravenous normal human immunoglobulin. She was also treated with a short course of parenteral glucocorticoids, vasoactive neurometabolites, nootropics, anticholinesterases, non-steroidal anti-inflammatory drugs along with physical therapy and massages. The patient began demonstrating slow but positive improvement in her limb motor functions and sensitivity within one month.


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Sejvar JJ, Baughman AL, Wise M, Morgan OW. Population incidence of Guillain-Barré syndrome: a systematic review and meta-analysis. Neuroepidemiology. 2011;36(2):123-133. doi:10.1159/000324710.

Guillain G, Barré JA, Strohl A. Radiculoneuritis syndrome with hyperalbuminosis of cerebrospinal fluid without cellular reaction. Notes on clinical features and graphs of tendon reflexes. Bul Mém Soc Med Hôp Paris.1916;40:1462-1470. (in French).

Akçay N, Menentoğlu ME, Bektaş G, Şevketoğlu E. Axonal Guillain-Barre syndrome associated with SARS-CoV-2 infection in a child. J Med Virol. 2021 Sep;93(9):5599-5602. doi:10.1002/jmv.27018.

Willison HJ, Jacobs BC, van Doorn PA. Guillain-Barré syndrome. Lancet. 2016 Aug 13;388(10045):717-727. doi:10.1016/S0140-6736(16)00339-1.

Yuki N, Hartung HP. Guillain-Barré syndrome. N Engl J Med. 2012 Jun 14;366(24):2294-304. doi:10.1056/NEJMra1114525.

Lehmann HC, Hartung HP, Kieseier BC, Hughes RA. Guillain-Barré syndrome after exposure to influenza virus. Lancet Infect Dis. 2010 Sep;10(9):643-651. doi:10.1016/S1473-3099(10)70140-7.

Shahrizaila N, Lehmann HC, Kuwabara S. Guillain-Barré syndrome. Lancet. 2021 Mar 27;397(10280):1214-1228. doi:10.1016/S0140-6736(21)00517-1.

Curtis M, Bhumbra S, Felker MV, et al. Guillain-Barré syndrome in a child with COVID-19 infection. Pediatrics. 2021 Apr;147(4):e2020015115. doi:10.1542/peds.2020-015115.

Mao L, Jin H, Wang M, et al. Neurologic Manifestations of Hospitalized Patients With Coronavirus Disease 2019 in Wuhan, China. JAMA Neurol. 2020 Jun 1;77(6):683-690. doi:10.1001/jamaneurol.2020.1127.

Montalvan V, Lee J, Bueso T, De Toledo J, Rivas K. Neurological manifestations of COVID-19 and other coronavirus infections: A systematic review. Clin Neurol Neurosurg. 2020 Jul;194:105921. doi:10.1016/j.clineuro.2020.105921.

Sheikh AB, Chourasia PK, Javed N, et al. Association of Guillain-Barre syndrome with COVID-19 infection: An updated systematic review. J Neuroimmunol. 2021 Jun 15;355:577577. doi:10.1016/j.jneuroim.2021.577577.

Jacobs BC, Rothbarth PH, van der Meché FG, et al. The spectrum of antecedent infections in Guillain-Barré syndrome: a case-control study. Neurology. 1998 Oct;51(4):1110-1115. doi:10.1212/wnl.51.4.1110.

Frank CHM, Almeida TVR, Marques EA, et al. Guillain-Barré Syndrome Associated with SARS-CoV-2 Infection in a Pediatric Patient. J Trop Pediatr. 2021 Jul 2;67(3):fmaa044. doi:10.1093/tropej/fmaa044.

Fisher M. An unusual variant of acute idiopathic polyneuritis (syndrome of ophthalmoplegia, ataxia and areflexia). N Engl J Med. 1956 Jul 12;255(2):57-65. doi:10.1056/NEJM195607122550201.

Khodak LA, Skripchenko NI, Navet TI. On the issue of acute flaccid paralysis in children. In: Proceedings of the IX Congress of Russian Pediatricians on Children's healthcare in Russia: a development strategy. 2001, February 19-22; Moscow, Russian Federation. Moscow; 2001. 149-150 pp. (in Russian).

Grygorova IA, Sokolova LI, Gerasymchuk RD, et al., authors; Grygorova IA, Sokolova LI, editors. Nevrologija: nacional'nyj pidruchnyk [Neurology: a national textbook]. Kyiv: Medycyna; 2014. 230-640 pp. (in Ukrainian).



How to Cite

Koloskova, O., Tkachuk, R., Garas, M., Bilous, T., Romanchuk, L., & Sorochan, D. (2022). Guillain — Barré syndrome following asymptomatic COVID-19 in an adolescent: a clinical case. CHILD`S HEALTH, 17(1), 43–47.



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