Chronic gastroduodenitis associated with Helicobacter pylori in combination with giardiasis in children

Authors

DOI:

https://doi.org/10.22141/2224-0551.17.1.2022.1488

Keywords:

children, gastroduodenitis, Helicobacter pyloriзапальні захворювання верхніх відділів травного тракту, Giardia lamblia

Abstract

Background. The results of most scientific studies in recent years have made it possible to reconsider the traditional ideas about the pathogenesis of chronic gastroduodenitis (CGD) from a new perspective. The purpose was to investigate the clinical and endoscopic features of СGD associated with Helicobacter pylori (H.pylori) in combination with giardiasis. Materials and methods. The study included 105 children aged 7–16 years divided into two groups: I — patients with СGD associated with H.pylori (n = 29), II — children with СGD associated with H.pylori in combination with giardiasis (n = 76). The study was conducted on the basis of the gastroenterology department of the Chernivtsi Regional Clinical Hospital during 2020–2021 and included esophagogastroduodenofibroscopy, ultrasound examination of the abdominal cavity, rapid urease test, determination of specific M, A and G immunoglobulins to H.pylori CagA antigen in the blood serum and in feces, fecal examination for Giardia lamblia (G.lamblia) antigen by polymerase chain reaction. Results. The most severe infection of G.lamblia occurred in children aged 9–13 years (17 people out of 29 positive). The number of children with G.lamblia increased between the ages of 7–9 and 10–12 years (p < 0.05, χ2 = 5.236, z = 1.899) and decreased in the age of 13–16 years (p < 0.05, χ2 = 7.144, z = 2.567). Patients with giardiasis complained of irritability (p < 0.05), heada­che, dizziness, restless sleep, heart pain, and they were more likely to show signs of intoxication and skin syndromes. Children of group I were most often diagnosed with corpus gastritis (p < 0.05), antral gastritis (p < 0.05) or pangastritis (p < 0.05) with focal hyperplasia (p < 0.05), and children of group II — with mainly antral gastritis, as well as severe duodenitis (p < 0.05). A characteristic endoscopic feature in children of group II was follicular duodenitis. Inflammatory process in group II significantly more often (p < 0.05) was severe (81.5 %) and active (77.6 %) and was associated with eosinophilic infiltration (51.3 %), microerosions and foci of lymphoid tissue hyperplasia (6.5 %). Conclusions. The clinical course of СGD associated with H.pylori in combination with G.lamblia is characterized by more pronounced dyspeptic symptoms with signs of intoxication and skin syndromes. According to the results of endoscopic examination, patients suffered from СGD associated with H.pylori infection had esophagitis, corpus gastritis, antral gastritis and pangastritis (p < 0.05) significantly more often. Children with G.lamblia invasion had severe follicular duodenitis (p < 0.05).

Downloads

Download data is not yet available.

References

Zryachkin NI, Chebotareva GI, Buchkova TN. Chronic gastritis and gastroduodenitis in preschool and school children. Voprosy detskoj dietologii. 2015;13(4):46-51. (in Russian).

Balko OA. Helicobacter pylori-associated chronic gastroduodenitis in children: constitutional features of the course. Children infections. 2020;19(1):34-36. doi:10.22627/2072-8107-2020-19-1-34-36. (in Russian).

Spużak J, Jankowski M, Kubiak K, Glińska-Suchocka K, Ciaputa R. A modified Sydney system for the diagnosis of chronic gastritis in dogs. Acta Vet Scand. 2020 Aug 12;62(1):44. doi:10.1186/s13028-020-00542-2.

Balko OA, Sapoghnikov VG. On the methods of diagnostics of the chronic gastroduodenit associated with helicobacter pylori depending on the somatotype at children (literature review). Journal of new medical technologies. 2019;26(2):5-11. (in Russian).

Mnich E, Kowalewicz-Kulbat M, Sicińska P, et al. Impact of Helicobacter pylori on the healing process of the gastric barrier. World J Gastroenterol. 2016 Sep 7;22(33):7536-7558. doi:10.3748/wjg.v22.i33.7536.

Reshetnyak VI, Burmistrov AI, Maev IV. Helicobacter pylori: Commensal, symbiont or pathogen? World J Gastroenterol. 2021 Feb 21;27(7):545-560. doi:10.3748/wjg.v27.i7.545.

Sharndama HC, Mba IE. Helicobacter pylori: an up-to-date overview on the virulence and pathogenesis mechanisms. Braz J Microbiol. 2022 Jan 6:1-18. doi:10.1007/s42770-021-00675-0.

De Lucio A, Martínez-Ruiz R, Merino FJ, et al. Molecular Genotyping of Giardia duodenalis Isolates from Symptomatic Individuals Attending Two Major Public Hospitals in Madrid, Spain. PLoS One. 2015 Dec 7;10(12):e0143981. doi:10.1371/journal.pone.0143981.

Bin Mohanna MA, Al-Zubairi LM, Sallam AK. Prevalence of Helicobacter pylori and parasites in symptomatic children examined for Helicobacter pylori antibodies, antigens, and parasites in Yemen. Saudi Med J. 2014 Nov;35(11):1408-1411.

Loderstädt U, Frickmann H. Antimicrobial resistance of the enteric protozoon Giardia duodenalis - A narrative review. Eur J Microbiol Immunol (Bp). 2021 Jul 8;11(2):29-43. doi:10.1556/1886.2021.00009.

Dangtakot R, Pinlaor S, Itthitaetrakool U, et al. Coinfection with Helicobacter pylori and Opisthorchis viverrini Enhances the Severity of Hepatobiliary Abnormalities in Hamsters. Infect Immun. 2017 Mar 23;85(4):e00009-17. doi:10.1128/IAI.00009-17.

Zajaczkowski P, Mazumdar S, Conaty S, Ellis JT, Fletcher-Lartey SM. Epidemiology and associated risk factors of giardiasis in a peri-urban setting in New South Wales Australia. Epidemiol Infect. 2018 Sep 28;147:e15. doi:10.1017/S0950268818002637.

Published

2022-04-28

How to Cite

Sorokman, T., Koliesnik, D., & Popelyuk, N. (2022). Chronic gastroduodenitis associated with Helicobacter pylori in combination with giardiasis in children. CHILD`S HEALTH, 17(1), 23–27. https://doi.org/10.22141/2224-0551.17.1.2022.1488

Issue

Section

Clinical Pediatrics

Most read articles by the same author(s)

1 2 3 4 > >>