Cerebral intestinal interaction in children with autism spectrum disorder

Authors

  • T.V. Stoieva Odessa National Medical University, Odesa, Ukraine https://orcid.org/0000-0002-9206-9827
  • I.H. Scherbak Children’s Special (Specialized) Sanatorium “Zelena Girka” of the Ministry of Health of Ukraine, Odesa, Ukraine
  • L.B. Bratkova Odessa National Medical University, Odesa, Ukraine https://orcid.org/0000-0003-3548-559X
  • O.V. Тitkova Odessa National Medical University, Odesa, Ukraine https://orcid.org/0000-0002-8697-0950
  • Kh.B. Soboleva Odessa National Medical University, Odesa, Ukraine
  • E.M. Krylov Children’s Special (Specialized) Sanatorium “Zelena Girka” of the Ministry of Health of Ukraine, Odesa, Ukraine
  • I.H. Scherbak Children’s Special (Specialized) Sanatorium “Zelena Girka” of the Ministry of Health of Ukraine, Odesa, Ukraine

DOI:

https://doi.org/10.22141/2224-0551.17.1.2022.1486

Keywords:

children, autism spectrum disorders, neurotransmitters, enteric nervous system

Abstract

Background. Autism spectrum disorders (ASD) in children are associated with features of neuropsychological development, characterized by socio-communicative, emotional, and behavioral problems. The processes of interaction between the central and enteric nervous systems, taking into account the inherent RAS reactions of autonomic maladaptation, endogenous stress, eating behavior determine the pathophysiological mechanisms underlying the comorbid pathology of the digestive system. The study was aimed to analyze the cerebral intestinal interaction signs in children with ASD, taking into account the role of NSE and S-100 neurotransmitters. Materials and methods. Sixty-six children with ASD were examined, out of which 45 children had concomitant functional disorders of the digestive system (FDDS). Clinical manifestations of ASD were assessed by the CARS scale; FDDS was diagnosed based on the Rome IV criteria. Serum le­vels of NSE neurotransmitters and S-100 protein were measured immunochemically. The patients were examined after obtaining informed consent in compliance with the principles of bioethics. Results. According to the data obtained in children with ASD, the frequency of concomitant FDDS is 68.20 %. In this case, ASD in combination with functional disorders of the biliary tract (FDBT) is observed in 22.7 %, with irritable bowel syndrome (IBS) — in 27.30 %, with syntropic FDDS — in 18.20 % of patients. The study traced the association between severe ASD and concomitant FDDS, in particular ASD with isolated IBS (p = 0.004), ASD with isolated FDBT (p = 0.009), ASD with syntropic functional disorders (p = 0.041). Increased serum concentrations of the NSE and S-100 neurotransmitters have been observed in children with concomitant FDDS. The level of S-100 protein and clinical manifestations of FDDS reveal a correlation, the degree of which increases in the following sequence: IBS (r = 0.34), and syntropic FDDS (r = 0.48). Conclusions. Peculiarities of cerebral intestinal interactions in ASD determine the high frequency of FDDS, in the structure of which IBS dominated. The presence of concomitant pathology impacts the clinical manifestations of ASD, complica­ting its course to a greater extent in cases of syntropic FDDS. Involvement of enteric glial structures in ASD is accompanied by the NSE and S-100 neurotransmitters level increase on the background of concomitant FDDS. The diagnostic value of S-100 protein in IBS in children with ASD is shown.

Downloads

Download data is not yet available.

References

Drossman DA. Functional Gastrointestinal Disorders: History, Pathophysiology, Clinical Features and Rome IV. Gastroenterology. 2016 Feb 19:S0016-5085(16)00223-7. doi: 10.1053/j.gastro.2016.02.032.

Stoieva TV, Dzhagiashvili OV, Larionov OP, Fedin MV. Peculiarties of syntropic functional disorders of the digestive system against the ground of connective tissue dysplasia. Deutscher Wissenschaftsherold. 2018;(1):9-13. doi: 10.19221/201813.

Penzol MJ, Salazar de Pablo G, Llorente C, et al. Functional Gastrointestinal Disease in Autism Spectrum Disorder: A Retrospective Descriptive Study in a Clinical Sample. Front Psychiatry. 2019 Apr 10;10:179. doi: 10.3389/fpsyt.2019.00179.

Fulceri F, Morelli M, Santocchi E, et al. Gastrointestinal symptoms and behavioral problems in preschoolers with Autism Spectrum Disorder. Dig Liver Dis. 2016 Mar;48(3):248-54. doi: 10.1016/j.dld.2015.11.026.

Wasilewska J, Klukowski M. Gastrointestinal symptoms and autism spectrum disorder: links and risks - a possible new overlap syndrome. Pediatric Health Med Ther. 2015 Sep 28;6:153-166. doi: 10.2147/PHMT.S85717.

Lefter R, Ciobica A, Timofte D, Stanciu C, Trifan A. A Descriptive Review on the Prevalence of Gastrointestinal Disturbances and Their Multiple Associations in Autism Spectrum Disorder. Medicina (Kaunas). 2019 Dec 27;56(1):11. doi: 10.3390/medicina56010011.

Barrea C, Jadot A, Debray FG, Vrancken G, Leroy P. Comment j’explore… un trouble du spectre de l’autisme chez l’enfant [How I explore… autism spectrum disorder in a child]. Rev Med Liege. 2021 Oct;76(10):761-767. (in French).

Grubišić V, Gulbransen BD. Enteric glia: the most alimentary of all glia. J Physiol. 2017 Jan 15;595(2):557-570. doi: 10.1113/JP271021.

Vergnolle N, Cirillo C. Neurons and Glia in the Enteric Nervous System and Epithelial Barrier Function. Physiology (Bethesda). 2018 Jul 1;33(4):269-280. doi: 10.1152/physiol.00009.2018.

Rosenberg HJ, Rao M. Enteric glia in homeostasis and disease: From fundamental biology to human pathology. iScience. 2021 Jul 15;24(8):102863. doi: 10.1016/j.isci.2021.102863.

do Carmo Neto JR, Braga YLL, da Costa AWF, et al. Biomarkers and Their Possible Functions in the Intestinal Microenvironment of Chagasic Megacolon: An Overview of the (Neuro)inflammatory Process. J Immunol Res. 2021 Apr 7;2021:6668739. doi: 10.1155/2021/6668739.

Haque A, Polcyn R, Matzelle D, Banik NL. New Insights into the Role of Neuron-Specific Enolase in Neuro-Inflammation, Neurodegeneration, and Neuroprotection. Brain Sci. 2018 Feb 18;8(2):33. doi: 10.3390/brainsci8020033.

Zheng Z, Zheng P, Zou X. Peripheral Blood S100B Levels in Autism Spectrum Disorder: A Systematic Review and Meta-Analysis. J Autism Dev Disord. 2021 Aug;51(8):2569-2577. doi: 10.1007/s10803-020-04710-1.

Chen H, Chen Y, Zhong JM. Detection and diagnostic value of serum NSE and S100B protein levels in patients with seizures associated with mild gastroenteritis: A retrospective observational study. Medicine (Baltimore). 2020 Nov 25;99(48):e23439. doi: 10.1097/MD.0000000000023439.

Toscano CVA, Carvalho HM, Ferreira JP. Exercise Effects for Children With Autism Spectrum Disorder: Metabolic Health, Autistic Traits, and Quality of Life. Percept Mot Skills. 2018 Feb;125(1):126-146. doi: 10.1177/0031512517743823.

Cerdó T, Diéguez E, Campoy C. Early nutrition and gut microbiome: interrelationship between bacterial metabolism, immune system, brain structure, and neurodevelopment. Am J Physiol Endocrinol Metab. 2019 Oct 1;317(4):E617-E630. doi: 10.1152/ajpendo.00188.2019.

Cryan JF, O'Riordan KJ, Cowan CSM, et al. The Microbiota-Gut-Brain Axis. Physiol Rev. 2019 Oct 1;99(4):1877-2013. doi: 10.1152/physrev.00018.2018.

Wang S, Harvey L, Martin R, et al. Targeting the gut microbiota to influence brain development and function in early life. Neurosci Biobehav Rev. 2018 Dec;95:191-201. doi: 10.1016/j.neubiorev.2018.09.002.

El-Ansary A, Hassan WM, Daghestani M, Al-Ayadhi L, Ben Bacha A. Preliminary evaluation of a novel nine-biomarker profile for the prediction of autism spectrum disorder. PLoS One. 2020 Jan 16;15(1):e0227626. doi: 10.1371/journal.pone.0227626.

Hewitson L, Mathews JA, Devlin M, Schutte C, Lee J, German DC. Blood biomarker discovery for autism spectrum disorder: A proteomic analysis. PLoS One. 2021 Feb 24;16(2):e0246581. doi: 10.1371/journal.pone.0246581.

Hyman SL, Levy SE, Myers SM; Сouncil on children with disabilities, section on developmental and behavioral pediatrics. Identification, Evaluation, and Management of Children With Autism Spectrum Disorder. Pediatrics. 2020 Jan;145(1):e20193447. doi: 10.1542/peds.2019-3447.

Ayaydın H, Kirmit A, Çelik H, Akaltun İ, Koyuncu İ, Bilgen Ulgar Ş. High Serum Levels of Serum 100 Beta Protein, Neuron-specific Enolase, Tau, Active Caspase-3, M30 and M65 in Children with Autism Spectrum Disorders. Clin Psychopharmacol Neurosci. 2020 May 31;18(2):270-278. doi: 10.9758/cpn.2020.18.2.270.

Lázaro CP, Pondé MP, Rodrigues LE. Opioid peptides and gastrointestinal symptoms in autism spectrum disorders. Braz J Psychiatry. 2016 Jul-Sep;38(3):243-6. doi: 10.1590/1516-4446-2015-1777.

Pandol S. The Future of Physiology: 2020 and Beyond. Front Physiol. 2021 Apr 12;12:674951. doi: 10.3389/fphys.2021.674951.

Liddle RA. Neuropods. Cell Mol Gastroenterol Hepatol. 2019;7(4):739-747. doi: 10.1016/j.jcmgh.2019.01.006.

Restrepo B, Angkustsiri K, Taylor SL, et al. Developmental-behavioral profiles in children with autism spectrum disorder and co-occurring gastrointestinal symptoms. Autism Res. 2020 Oct;13(10):1778-1789. doi: 10.1002/aur.2354.

Garcia-Gutierrez E, Narbad A, Rodríguez JM. Autism Spectrum Disorder Associated With Gut Microbiota at Immune, Metabolomic, and Neuroactive Level. Front Neurosci. 2020 Oct 8;14:578666. doi: 10.3389/fnins.2020.578666.

Al-Beltagi M. Autism medical comorbidities. World J Clin Pediatr. 2021 May 9;10(3):15-28. doi: 10.5409/wjcp.v10.i3.15.

Published

2022-06-02

How to Cite

Stoieva, T., Scherbak, I., Bratkova, L., Тitkova O., Soboleva, K., Krylov, E., & Scherbak, I. (2022). Cerebral intestinal interaction in children with autism spectrum disorder. CHILD`S HEALTH, 17(1), 11–17. https://doi.org/10.22141/2224-0551.17.1.2022.1486

Issue

Section

Clinical Pediatrics

Most read articles by the same author(s)