The systemic pro- and antioxidant processes in preschool children with recurrent acute respiratory diseases

Authors

  • L.S. Ovcharenko State Institution “Zaporizhzhia Medical Academy of Postgraduate Education of the Ministry of Health of Ukraine”, Zaporizhzhia, Ukraine https://orcid.org/0000-0001-9711-1329
  • O.V. Tymoshyna State Institution “Zaporizhzhia Medical Academy of Postgraduate Education of the Ministry of Health of Ukraine”, Zaporizhzhia, Ukraine https://orcid.org/0000-0001-8636-8532
  • A.O. Vertehel State Institution “Zaporizhzhia Medical Academy of Postgraduate Education of the Ministry of Health of Ukraine”, Zaporizhzhia, Ukraine https://orcid.org/0000-0002-6314-1826
  • T.G. Andrienko State Institution “Zaporizhzhia Medical Academy of Postgraduate Education of the Ministry of Health of Ukraine”, Zaporizhzhia, Ukraine
  • I.V. Samokhin State Institution “Zaporizhzhia Medical Academy of Postgraduate Education of the Ministry of Health of Ukraine”, Zaporizhzhia, Ukraine
  • O.V. Kryazhev State Institution “Zaporizhzhia Medical Academy of Postgraduate Education of the Ministry of Health of Ukraine”, Zaporizhzhia, Ukraine
  • O.M. Chakmazova State Institution “Zaporizhzhia Medical Academy of Postgraduate Education of the Ministry of Health of Ukraine”, Zaporizhzhia, Ukraine

DOI:

https://doi.org/10.22141/2224-0551.16.7.2021.244575

Keywords:

children, peroxidation, anti-oxidant protection, infection

Abstract

Background. The imbalance of innate defense early mechanisms in children from pathogens — peroxidation and antioxidant system, can lead to a decrease in the efficiency of the entire immune system. The study of the lipid peroxidation (LPO) and antioxidant protection (AOP) status in children with recurrent acute respiratory diseases will complement the scientific data on the antimicrobial immunity formation processes. The study was aimed to increase the information value of timely detected pro- and antioxidant processes disorders in children with recurrent acute respiratory diseases by studying the primary, secondary, tertiary, and quaternary compounds of LPO and AOP in the serum. Materials and methods. Sixty children aged from 2 to 5 years were examined. Two groups were formed: group 1 — children with respiratory acute infectious more than six times per year (n = 30); group 2 — children with respiratory acute infectious six or fewer times per year (n = 30). Results. The children in group 1 more often presented with high serum levels of lipid hydroperoxides (by 80.0 %; p < 0.05), diene conjugates (by 80.0 %; p < 0.05), malonic dialdehyde (76.7 %; p < 0.05), diene ketones (76.7 %; p < 0.05), Schiff bases (76.7 %; p < 0.05). ceruloplasmin (80.0 %; p < 0.05), superoxide dismutase (80.0 %; p < 0.05), glutathione peroxidase (86.7 %; p < 0.05), catalase activity (86.7 %; p < 0.05). The values of retinol, tocopherol, ascorbic acid in children in the observation groups did not differ statistically significantly. Conclusions. The children aged from 2 to 5 years old with recurrent acute respiratory diseases have an imbalance of the LPO and AOP systems. It was characterized by a simultaneous increase in the serum content of the primary, secondary, and end-products of LPO, enzymes of anti-peroxide and anti-oxygen protection against the background of the lack of adaptive increase in the content of anti-radical compounds.

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Published

2022-01-19

How to Cite

Ovcharenko, L., Tymoshyna, O., Vertehel, A., Andrienko, T., Samokhin, I., Kryazhev, O., & Chakmazova, O. (2022). The systemic pro- and antioxidant processes in preschool children with recurrent acute respiratory diseases. CHILD`S HEALTH, 16(7), 461–466. https://doi.org/10.22141/2224-0551.16.7.2021.244575

Issue

Section

Clinical Pediatrics

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