Indicators of physical development of children with celiac disease


  • T.V. Sorokman SHEI “Bukovinian State Medical University”, Chernivtsi, Ukraine
  • N.O. Popelyuk SHEI “Bukovinian State Medical University”, Chernivtsi, Ukraine
  • D.I. Kolesnik SHEI “Bukovinian State Medical University”, Chernivtsi, Ukraine
  • І.S. Sokolnyk SHEI “Bukovinian State Medical University”, Chernivtsi, Ukraine



children, celiac disease, physical development


Background. Given the clinical polymorphism of celiac disease, it is often undiagnosed for several years that causes the development of serious changes in nutritional status, hormo­nal and metabolic restructuring, growth retardation, malnutrition and deficiency. The purpose of the study is to evaluate the physical development of children and adolescents based on a comprehensive analysis of the anthropometric parameters during the clinical manifestation of celiac disease. Materials and methods. The results of a survey of 59 children and adolescents aged 6 months to 18 years with a verified diagnosis of celiac disease were analysed. Anthropometric measurements were carried out in the morning by conventional methods. The data obtained from anthropometric measurements of children were estimated by regional standards. The deviation of the body length index relative to age (SDS body length), body weight relative to body length (SDS body weight) was calculated. Statistical processing included the calculation of the arithmetic mean of each of the indicators (M), the standard deviation (s), mean error of the arithmetic mean (m), the probability of differences of the mean values by the Student t-test, p < 0.05. Results. Indicators of physical development of children with celiac disease varied significantly depending on the age of diagnosis verification and the duration of the latent period of the disease. In the structure of clinical manifestations in the patients in the acute period of celiac disease, the delay of physical development is in the first place — 84.7 % of people. In this case, 76.3 % of children have a reported body mass deficit, of which grade I body mass deficit is in 71.1 %, grade II body weight deficit is in 22.2 %, and grade III body weight deficit is in 6.7 % of cases. Growth retardation was found in 52.5 % of children: somatogenic dwarfism was detected in 10.1 % of patients and low growth in 42.3 % of children. Assessment of the atrophy stage according to the Marsh-Oberhuber classification showed that the children with a more severe form of body weight deficit were diagnosed with Marsh 3C type, whereas with a slight lag in body mass indicators, the types of Marsh 3A and Marsh 3B were diagnosed. Conclusions. Anthropometric parameters of patients with celiac disease are inversely dependent on the duration of the latent period and the age of the disease diagnosis. In young children, body weight deficit outweighs growth retardation, whereas older children experience a slowdown in growth with the formation of stunting and somatogenic dwarfism.


Download data is not yet available.


Gidrewicz D, Potter K, Trevenen CL, Lyon M, Butzner JD. Evaluation of the ESPGHAN Celiac Guidelines in a North American Pediatric Population. Am J Gastroenterol. 2015;110(5):760-767. doi: 10.1038/ajg.2015.87.

Husby S, Murray JA, Katzka DA. AGA Clinical Practice Update on Diagnosis and Monitoring of Celiac Disease-Changing Utility of Serology and Histologic Measures: Expert Review. Gastroenterology. 2019;156(4):885-889. doi: 10.1053/j.gastro.2018.12.010.

Meis M, Adamiak T. Pediatric celiac disease - a review. S D Med. 2018;71(12):559-564.

Green PH, Jabri B. Celiac disease. Lancet. 2003;362(9381):383-391. doi:10.1016/S0140-6736(03)14027-5.

Ermarth A, Bryce M, Woodward S, Stoddard G, Book L, Jensen MK. Identification of Pediatric Patients With Celiac Disease Based on Serology and a Classification and Regression Tree Analysis. Clin Gastroenterol Hepatol. 2017;15(3):396-402.e2. doi: 10.1016/j.cgh.2016.10.035.

Semwal P, Gupta RK, Sharma R, Garg K. Comparison of Endoscopic and Histological Findings between Typical and Atypical Celiac Disease in Children. Pediatr Gastroenterol Hepatol Nutr. 2018;21(2):86-92. doi: 10.5223/pghn.2018.21.2.86.

Majsiak E, Cichoż-Lach H, Gubska O, Cukrowska B. Celiac disease - disease of children and adults: symptoms, disease complications, risk groups and comorbidities. Pol Merkur Lekarski. 2018;44(259):31-35. (in Polish).

Popp A, Mäki M. Gluten-Induced Extra-Intestinal Manifestations in Potential Celiac Disease-Celiac Trait. Nutrients. 2019;11(2):320. doi: 10.3390/nu11020320.

Belmer SV, Semenova EV, Smetanina NS. Hematologic manifestations of celiac disease. In: Belmer SV, Semenova EV, Smetanina NS, et al, authors; Belmer SV, Revnova MO, editors. Tseliakiia u detei [Celiac disease in children]. Moscow: Medpraktika-M; 2013. 261-274 pp. (in Russian).

Frühauf P, Nabil El-Lababidi N, Szitányi P. Celiac disease in children and adolescents. Cas Lek Cesk. 2018;157(3):117-121. (in Czech).

Saeed A, Assiri A, Assiri H, Ullah A, Rashid M. Celiac disease in Saudi children. Evaluation of clinical features and diagnosis. Saudi Med J. 2017;38(9):895-899. doi: 10.15537/smj.2017.9.20808.

Oliveira GN, Mohan R, Fagbemi A. Review of celiac disease presentation in a pediatric tertiary centre. Arq Gastroenterol. 2018;55(1):86-93. doi: 10.1590/S0004-2803.201800000-17.

Reilly NR, Hammer ML, Ludvigsson JF, Green PH. Frequency and Predictors of Successful Transition of Care for Young Adults With Childhood Celiac Disease. J Pediatr Gastroenterol Nutr. 2020;70(2):190-194. doi: 10.1097/MPG.0000000000002568.

Singh P, Sharma PK, Agnihotri A, et al. Coeliac disease in patients with short stature: A tertiary care centre experience. Natl Med J India. 2015;28(4):176-180.

Pooni PA, Chhina RS, Jaina BK, Singh D, Gautam A. Clinical and anthropometric profile of children with celiac disease in Punjab (North India). J Trop Pediatr. 2006;52(1):30-33. doi: 10.1093/tropej/fmi054.

Saadah OI. Short children with impaired growth hormone secretion. Do they have celiac disease? Saudi Med J. 2020;41(1):68-72. doi: 10.15537/smj.2020.1.24785.

Meazza C, Pagani S, Laarej K, et al. Short stature in children with coeliac disease. Pediatr Endocrinol Rev. 2009;6(4):457-463.

Troncone R, Kosova R. Short stature and catch-up growth in celiac disease. J Pediatr Gastroenterol Nutr. 2010;51 Suppl 3:S137-S138. doi: 10.1097/MPG.0b013e3181f1dd66.

Caio G, Volta U, Sapone A, et al. Celiac disease: a comprehensive current review. BMC Med. 2019;17(1):142. doi: 10.1186/s12916-019-1380-z.

Nenna R, Mosca A, Mennini M, et al. Coeliac disease screening among a large cohort of overweight/obese children. J Pediatr Gastroenterol Nutr. 2015;60(3):405-407. doi: 10.1097/MPG.0000000000000656.

Guandalini S, Assiri A. Celiac disease: a review. JAMA Pediatr. 2014;168(3):272-278. doi: 10.1001/jamapediatrics.2013.3858.

Nenna R, Tiberti C, Petrarca L, et al. The celiac iceberg: characterization of the disease in primary schoolchildren. J Pediatr Gastroenterol Nutr. 2013;56(4):416-421. doi: 10.1097/MPG.0b013e31827b7f64.

Klimov LYa, Kuryaninova VA, Stoian MV, Kuleshova OK, Kashpkov BC. Frequency and structure of forms of malnutrition in children with celiac disease. In: Abstracts of the XIX Congress of Pediatric Gastroenterologists of Russia and the CIS countries. 2012, March 13-15; Moscow, Russian Federation. Pediatric Nutrition. 2012;10(2):70-71. (in Russian).

Klimov LYa, Stoyan MV, Kuryaninova VA, et al. Anthropometric measures of children in the period of clinical manifestation of celiac disease. Eksperimental'naia i klinicheskaia gastroenterologiia. 2013;(1):55-59. (in Russian).

Kuryaninova VA, Alaverdyan LS, Gerasimenko ES, et al. Modern views on the pathogenesis of celiac disease: the relationship between digestive and hormonal and metabolic disorders. Journal of Young Scientist. 2013;5(3-4):25-31. (in Russian).

Husby S, Koletzko S, Korponay-Szabó I, et al. European Society Paediatric Gastroenterology, Hepatology and Nutrition Guidelines for Diagnosing Coeliac Disease 2020. J Pediatr Gastroenterol Nutr. 2020;70(1):141-156. doi: 10.1097/MPG.0000000000002497.

Werkstetter KJ, Korponay-Szabó IR, Popp A, et al. Accuracy in Diagnosis of Celiac Disease Without Biopsies in Clinical Practice. Gastroenterology. 2017;153(4):924-935. doi: 10.1053/j.gastro.2017.06.002.

Popp A, Kivelä L, Fuchs V, Kurppa K. Diagnosing Celiac Disease: Towards Wide-Scale Screening and Serology-Based Criteria?. Gastroenterol Res Pract. 2019;2019:2916024. doi: 10.1155/2019/2916024.

Marsh MN, Johnson MW, Rostami K. Rebutting Oberhuber- Again. Gastroenterol Hepatol Bed Bench. 2015;8(4):303-305.

Abreu Paiva LM, Gandolfi L, Pratesi R, et al. Measuring quality of life in parents or caregivers of children and adolescents with celiac disease: development and content validation of the questionnaire. Nutrients. 2019;11(10):2302. doi: 10.3390/nu11102302.



How to Cite

Sorokman, T., Popelyuk, N., Kolesnik, D., & Sokolnyk І. (2021). Indicators of physical development of children with celiac disease. CHILD`S HEALTH, 15(1), 1–5.



Clinical Pediatrics

Most read articles by the same author(s)

1 2 3 4 > >>