Recurrent respiratory infections in pediatric practice: the effectiveness of the use of inosine pranobex
Keywords:review, recurrent respiratory infections, children, inosine pranobex
AbstractThe review of literature presents current data on terminology and causes of recurrent respiratory infections in children, the immunological basis for the recurrence of respiratory tract infections in childhood. A scheme of the standard examination of a child with recurrent respiratory infections is presented. Characteristics of inosine pranobex, possessing antiviral and immunomodulatory action, are given. The results of studies on the clinical efficacy of inosine pranobex in recurrent respiratory infections in children are summarized. Dosage and regimens of inosine pranobex use are shown in recurrent respiratory diseases in children.
Abaturov AE, Nikulina AA, Tokareva NM. Effect of treatment with inosine pranobex in acute respiratory viral infections in children. Zdorovʹe rebenka. 2018;13(5):478-483. doi: 10.22141/2224-05126.96.36.1998.141565. (in Russian).
Zaplatnikov AL. Kliniko-patogeneticheskoe obosnovanie immunoterapii i immunoprofilaktiki virusnykh i bakterial'nykh zabolevanii u detei. Diss. dokt. med. nauk [Clinico-pathogenetic substantiation of immunotherapy and immunoprophylaxis of viral and bacterial diseases in children. Dr. med. sci. diss.]. Moskow; 2003. 233 р. (in Russian).
Zemskov VM. Immunomodulating properties of inosine preparations and their analogues. Uspehi sovremennoj biologii. 1989;107(1):69-78. (in Russian).
Zakharova IN, Cheburkin AV, Malinovskaya VV, et al. The significance of the interferon system for formation of the immune response in children with acute respiratory viral infections. Clinical Practice in Pediatrics. 2009;4(5):38-45. (in Russian).
Osidak LV, Zarubaev VV, Obraztsova EV, Erman ES, Drinevsky VP. Isoprinosin in the treatment of acute respiratory viral infarction in frequently ill children. Children's Infections. 2008;7(4):35-41. (in Russian).
Bulgakova VA, Balabolkin II, Sedova MS, Shmakova SG, Zubkova IV, Korolkova EL. Clinical and immunological efficacy of inosine pranobex for acute respiratory infections in children with atopic asthma. Pediatricheskaya Farmakologiya. 2010;7(3):98-105. (in Russian).
Kuprina NP, Kokoreva SP, Aralova YeV. Influence of environmental factors on the health status of frequently ill children and the specific features of their immune response. Epidemiologiya i Infektsionnye Bolezni. 2008;(4):32-35. (in Russian).
Lapshin VF, Umanets TR. Rehabilitation of often ill children. Zdorov`ja Ukrai'ny. 2006;(6):21-24. (in Russian).
Yulish YeI, Balychevtseva IV, Krivushchev BI, Gadetskaia SG, Iaroshenko SIa. The method of differentiated approach to the treatment and rehabilitation of often and long-term ill children with different persistent infections. Klinichna immunologija. Alergologija. Infektologija. 2010;(31):52-57. (in Russian).
Nedelskaya SN, Yartseva DA. Diagnostics of bronchial asthma in infants: possibilities, topical issues, differential diagnosis. Zdorovʹe rebenka. 2013;(45):108-111. doi: 10.22141/2224-05188.8.131.523.88245. (in Russian).
Okhotnikova ЕN, Rudenko SN, Kolomiets EN. Recurrent respiratory tract infections in children and their immunoprophylaxis in the terms of modern ideas about immunomodulatory activity of immunotropic preparations. Sovremennaya pediatriya. 2013;(49):42-50. (in Russian).
Nisevich LL, Volkov KS, Alekseeva АА, et al. Approaches to the treatment of acute respiratory infections and influenza during the seasonal increase in the incidence of diseases. Voprosy Sovremennoi Pediatrii. 2015;14(1):64-69. (in Russian).
Chebotareva TA, Mazankova LN, Hoperskova AP, Malinovskaya VV, Koltsov VD, Bragina GS. Recurrent Respiratory Infections in Children and the Program Immunorehabilitation. Children's Infections. 2014;13(3):61-64. doi: 10.22627/2072-8107-2014-13-3-61-64. (in Russian).
Samsyginа GA. Frequently ill children: problems of pathogenesis, diagnosis, therapy. Pediatria. 2005;1:66-73. (in Russian).
Simovanyan EN, Badalyants EE, Sizyakina LP, Lebedenko AA, Denisenko VB, Kim MA. An improvement of the child acute respiratory infection treatment program. Pediatricheskaya Farmakologiya. 2013;10(1):83-90. (in Russian).
Shamsheva OV, Boitsov VP. Experience of using different courses of inosine pranobex in the therapy of acute respiratory viral infection and influenza in children. Lechaschii Vrach. 2013;(8):92-95. (in Russian).
Eliseeva MIu, Tsarev VN, Masikhi KN, et al. The effectiveness of auxiliary immunotherapy in patients with immunodeficiency and frequently ill children: a systematic review and meta-analysis of the use of inosine pranobex in ARVI. RMJ. 2010;18(5):313-320. (in Russian).
Bartlett JG. Management of Respiratory Tract Infections. 3rd ed. Philadelphia: Lippincott Williams&Wilkins; 2001. 277 p.
Campoli-Richards DM, Sorkin EM, Heel RC. Inosine pranobex. A preliminary review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy. Drugs. 1986 Nov;32(5):383-424. doi: 10.2165/00003495-198632050-00001.
Bitko V, Musiyenko A, Bayfield MA, Maraia RJ, Barik S. Cellular La protein shields nonsegmented negative-strand RNA viral leader RNA from RIG-I and enhances virus growth by diverse mechanisms. J Virol. 2008 Aug;82(16):7977-87. doi: 10.1128/JVI.02762-07.
Kusel MM, de Klerk NH, Kebadze T, Vohma V, Holt PG, Johnston SL, Sly PD. Early-life respiratory viral infections, atopic sensitization, and risk of subsequent development of persistent asthma. J Allergy Clin Immunol. 2007 May;119(5):1105-10. doi: 10.1016/j.jaci.2006.12.669.
Jansen RR, Wieringa J, Koekkoek SM, et al. Frequent detection of respiratory viruses without symptoms: toward defining clinically relevant cutoff values. J Clin Microbiol. 2011 Jul;49(7):2631-6. doi: 10.1128/JCM.02094-10.
Nokso-Koivisto J, Kinnari TJ, Lindahl P, Hovi T, Pitkäranta A. Human picornavirus and coronavirus RNA in nasopharynx of children without concurrent respiratory symptoms. J Med Virol. 2002 Mar;66(3):417-20.
Jankowski A, Kowalik W, Szyszka Z, Sznajder W, Stasiewicz U, Szenborn L. Isoprinosine and climatotherapy at the Czerniawa-Zdrój health resort in the treatment of children with recurrent respiratory tract infections. Pneumonol Pol. 1989 Mar;57(3):192-5.
Van Niekerk A, Esser M. A diagnostic approach to recurrent respiratory tract infections in childwood: could it be primary immunodeficiency? Current Allergy & Clinical Immunology. 2015 Dec;28(4):308-312.
Slatter MA, Gennery AR. Clinical immunology review series: an approach to the patient with recurrent infections in childhood. Clin Exp Immunol. 2008 Jun;152(3):389-96. doi: 10.1111/j.1365-2249.2008.03641.x.
Stenzel T, Tykałowski B, Smiałek M, Koncicki A, Kwiatkowska-Stenzel A. The effect of different doses of methisoprinol on the percentage of CD4+ and CD8+ T lymphocyte subpopulation and the antibody titers in pigeons immunised against PPMV-1. Pol J Vet Sci. 2011;14(3):367-71.
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