Health status and indicators of stress-regulatory systems in children with cardiorheumatologic diseases from the zone of anti-terrorist operation


  • I.S. Lebets State Institution “Institute for Children and Adolescents Health Care of the NAMS of Ukraine”, Kharkiv, Ukraine V.N. Karazin Kharkiv National University, Kharkiv, Ukraine
  • S.R. Tolmacheva State Institution “Institute for Children and Adolescents Health Care of the NAMS of Ukraine”, Kharkiv, Ukraine V.N. Karazin Kharkiv National University, Kharkiv, Ukraine
  • D.A. Kashkalda State Institution “Institute for Children and Adolescents Health Care of the NAMS of Ukraine”, Kharkiv, Ukraine
  • V.V. Nikonova State Institution “Institute for Children and Adolescents Health Care of the NAMS of Ukraine”, Kharkiv, Ukraine



children from the antiterrorist operation zone, cardiorheumatologic diseases, stress-regulating systems


Background. To characterize the health status of children from the antiterrorist operation zone in the east of Ukraine with cardiorheumatologic pathology and to study the indicators of stress-regulating systems was the purpose of our work. Materials and methods. A clinical and instrumental exa­mination was performed in 126 children aged 8–18 years, 92 of them from the anti-terrorist operation zone and 34 immigrant children from the Donetsk and Luhansk regions. The comparison group consisted of 509 children of the same age from the Kharkiv region and Kharkiv. The intensity of stress-realizing systems was determined by the level of cortisol, thiobarbituric acid-active products and diene conjugates in the blood serum, epinephrine and norepinephrine in daily urine. The state of stress-limiting systems was assessed by the content of serotonin, reduced glutathione, activity of glutathione pe­roxidase and superoxide dismutase in the blood and melatonin in daily urine. Results. In the structure of somatic pathology of children and adolescents from zone of military operations in the east of Ukraine, cardiorheumatologic diseases rank se­cond, the first place belongs to diseases of the digestive system. In 34.1 % of children admitted to the institute for the first time, the deterioration of health occurred against the background of psychoemotional stress and lack of conditions for treatment in the main place of residence. In the structure of patients’ complaints, astheno-neurotic ones prevailed, which was significantly more frequent in children of the first group. Also, various psychosomatic disorders, diseases of the digestive system and endocrinopathy were diagnosed most often. The study of stress-regulating systems in children from the anti-terrorist operation zone revealed some differences in the indicators, taking into account the nosology. Thus, patients with cardiovascular patho­logy had an activation of stress-realizing systems, and children with rheumatic diseases — stress of stress-limiting systems. The revealed changes in melatonin level and superoxide dismutase activity in patients with diseases of the circulatory system from the anti-terrorist operation zone indicate an imbalance of enzyme and non-enzyme antioxidants, which can lead to oxidative stress as one of the components of post-traumatic stress disorder. Thus, the obtained data should be taken into account when developing individual programs for medical rehabilitation in children and adolescents with cardiorheumatologic patho­logy from zone of military operations, taking into account the concomitant pathology. Conclusions. Children from the war zone have an imbalance in the components of antioxidant stress responsible for the stress-resistance of the body to damaging factors. The activation of stress-realizing systems in diseases of the circulatory system and the stress of stress-limiting systems in rheumatic diseases have been established.


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How to Cite

Lebets, I., Tolmacheva, S., Kashkalda, D., & Nikonova, V. (2021). Health status and indicators of stress-regulatory systems in children with cardiorheumatologic diseases from the zone of anti-terrorist operation. CHILD`S HEALTH, 13(2), 176–181.



Clinical Pediatrics

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