Preventive and therapeutic effectiveness of bioflavonoids in children with recurrent respiratory infections

O.M. Mukvich, T.M. Kaminskaya

Abstract


Тhe aim of the study was to increase the effectiveness of treatment and prevention of acute recurrent respiratory infections (ARRI) by Imunoflazid® syrup usage in children of primary school age. Materials and methods. The study included 50 children of primary school age with ARRI. Preventive and curative efficacy of Immunoflazid® syrup was determined by studying the dynamics of clinical symptoms within the year, parameters of saliva microcrystallization (SMC), bacterial composition of pharyngeal exudates. Conclusions. Immunoflazid® syrup used for preventive and curative purpose improves general well-being in children, reduces the manifestations of toxipathy, asthenia, the frequency and severity of acute respiratory infections, number of sick days, the number and duration of hospitalizations, increases mineralizing potential of saliva against the background of reduction of the microbiological load of the oral cavity.

Keywords


Immunoflazid®; bioflavonoids; acute recurrent respiratory infections; treatment; prevention; schoolchildren

References


Abaturov AYe, Vysochina IL. Realization of antiviral and antioxidant effects of bioflavonoids in treatment of acute respiratory viral infections. Zdorov'ye Rebenka. 2016;5(73):42-8. (in Russian)..

Beketova GV, Khaitovich NV, Grinevich AI. Immunoflazidum in pediatrics: system analysis of effectiveness and safety. Pediatrija. Vostochnaja Evropa. 2014;2(07):141-52. (in Russian).

Gonchar FL, Pokhodenko-Chudakova IO. Microcrystallization of oral fluid as a general homeostasis parameter. In: Proceeding of Republic Scientific Research Conference: Innovative approaches to practical decisions of topic problems in maxillofacial surgery and dentistry. Minsk; 2010. p. 70-2. (in Russian).

Leus PA. Diagnosticheskoe znachenie gomeostaza sljuny v klinike terapevticheskoj stomatologii : uchebno-metodicheskoe posobie [Diagnostic value of saliva homeostasis in clinical picture of therapeutic dentistry: textbook]. Minsk: Belorussian State Medical University; 2011. 67p. (in Russian).

Kobiyasova IV, Savushkina NA. Features of mineralizing saliva function in adolescents of pubertal age and methods for its correction. Sovremennaja stomatologija. 2006;2:64-7. (in Russian).

Mukvich OM, Kaminska TM. Organization of preventive-rehabilitation measures at school. Sovremennaya pediatriya. 2016;3(75):15-18. doi: 10.15574/SP.2016.75.15. (in Ukrainian).

Nedilko VP, Kaminska TM, et al. Ways for improvement of health in schoolchildren. Sovremennaya pediatriya. 2010;3(31):81-4. (in Ukrainian).

Rybalko SL. Otchet “Izuchenie mehanizmov dejstvija biologicheski aktivnih veshhestv lechebnoj substancii Proteflazid” [Report “Study of mechanisms of biologically active substances of remedial Proteflazidum]; 2010. 84p. (in Russian).

Yulish YeI, Ivanova LA, Chernyshova OE. Immune impairments in sickly children and chronic children. Pedіatrіja, akusherstvo ta gіnekologіja. 2003;4:109. (in Russian).

Hosakote YM, Liu T, Castro SM, et al. Respiratory syncytial virus induces oxidative stress by modulating antioxidant enzymes. Am J Respir Cell Mol Biol. 2009 Sep;41(3):348-57. doi: 10.1165/rcmb.2008-0330OC.

Hosakote YM, Jantzi PD, Esham DL, et al. Viral-mediated inhibition of antioxidant enzymes contributes to the pathogenesis of severe respiratory syncytial virus bronchiolitis. Am J Respir Crit Care Med. 2011 Jun 1;183(11):1550-60. PMID: 21471094. PMCID: PMC3137144. doi: 10.1164/rccm.201010-1755OC.

Lyu SY, Rhim JY, Park WB. Antiherpetic activities of flavonoids against herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) in vitro. Arch. Pharm Res. 2005 Nov;28(11):1293-301. PMID:16350858.

de Martino M, Ballotti S. The child with recurrent respiratory infections: normal or not? Pediatr Allergy Immunol. 2007;18 Suppl 18:13-8. doi: 10.1111/j.1399-3038.2007.00625.x. PMID: 17767600.

Stensson M, Wendt LK, Koh G, et al. Oral health in pre-school children with asthma — followed from 3 to 6 years. Int J Paediatr Dent. 2010;20(3):165-72. PMID: 20409196. doi: 10.1111/j.1365-263X.2010.01037.x.

Ozcelik B, Kartal M, Orhan I. Cytotoxicity, antiviral and antimicrobial activities of alkaloids, flavonoids, andphenolicacids. Pharm Biol. 2011;49(4):396-402. PMID: 21391841. doi: 10.3109/13880209.2010.519390.

Gescher K, Kühn J, Lorentzen E, et al. Proanthocyanidin-enriched extract from Myrothamnus flabellifolia Welw. exerts antiviral activity against herpes simplex virus type 1 by inhibition of viral adsorption and penetration. Journal of Ethnopharmacology. 2011 Mar 24;134(2):468-74. PMID: 21211557. doi: 10.1016/j.jep.2010.12.038.

Odenthal J, van Heumen BW, Roelofs HM, et al. The influence of curcumin, quercetin, and eicosapentaenoic acid on the expression of phase II detoxification enzymes in the intestinal cell lines HT-29, Caco-2, HuTu 80, and LT97. Nutr. Cancer. 2012;64(6):856-63. PMID: 22830632. doi: 10.1080/01635581.2012.700994.




DOI: https://doi.org/10.22141/2224-0551.12.2.2017.99767

Refbacks

  • There are currently no refbacks.


Copyright (c) 2017 CHILD`S HEALTH

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

 

© Publishing House Zaslavsky, 1997-2017

 

 Яндекс.МетрикаSeo анализ сайта Рейтинг@Mail.ru