Features of the inflammatory response in infants with congenital and acquired pneumonia
Background. Congenital infection protection factors are proteins-cytokines, their formation and secretion occurs in response to the presence of the antigen in the body. Objective: to explore the features of the inflammatory response of newborns with congenital and acquired pneumonia in terms of interleukin (IL) 1β and 10. Materials and methods. Clinical and paraclinical examination of 69 term infants with pneumonia were performed. They underwent clinical and paraclinical studies (C-reactive protein (CRP), interleukin 1β and 10 content in the blood serum, X-ray examination of the chest). Results. It was found that the content of ІL-1β in children of group I and II significantly exceeded the indicators of the control group. However, the rate of ІL-1β in children from group I was significantly lower than in children of group II. In children from group II, who required artificial ventilation, IL-10 content was significantly higher compared to those, who did not need artificial ventilation. It was also determined the dependence of ІL-1β and IL-10 indicators on CRP levels — the higher the CRP, the lower the level of ІL-1β and IL-10. Evaluation of ІL-1β and IL-10 content depending on the localization of the inflammatory process in the lungs showed that with the proliferation of infiltrative changes in the lungs of children from group II, there was an increase in the level of ІL-1β and IL-10, and in children from group I — a reduction. Conclusions. The level of IL-1β in children of group I and II significantly exceeded the levels of the control group, and the IL-10 index — did not. However, the rate of IL-1β in children from group I was significantly lower than in children of group II. It was established the inverse correlation of IL-1β and IL-10 content with the severity of inflammation in the lungs and the level of CRP in the blood serum.
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Bajgozina EA, Sovalkin VI, Dolgih TY. The cytokine profile in patients with ventilator-associated pneumonia. Citokiny i Vospalenie. 2007;2:35-39. (in Russian).
Markelova EV, Kostjushko AV, Krasnikov VE. Pathogenetic role of disturbances in the system of cytokines in infectious and inflammatory diseases. Tihookeanskij Medicinskij Zhurnal. 2008;3:24-29. (in Russian).
Jablon’ OS. The role of excessive inflammatory response in the formation of the pathology associated with very low birth weight. Perynatologija i pediatrija. 2007;4:28-30. (in Ukrainian).
Bohrer B, Silveira RC, Neto EC, Procianoy RS. Mechanical Ventilation of Newborns Infant Changes in Plasma Pro- and Anti-Inflammatory Cytokines. The Journal of Pediatrics. 2010;156(1):16-19.
Cesur S, Irmak H, Eras Z, et al. Prognostic value of serum TNF-alpha, IL-10, leptin and CRP levels in newborns with septicemia. Mikrobiyol Bul. 2009;43(4):607-612.
Chung EY, Liu J, Homma Y, et al. Interleukin-10 expression in macrophages during phagocytosis of apoptotic cells is mediated by homeodomain proteins Pbx1 and Prep-1. Immunity. 2007;27(6):952-964.
Jobe AH. Blood cytokines and BPD. J Pediatr. 2009;154:A2.
Lindberg E, Magnusson Y, Karason K, Andersson B. Lower levels of the host protective IL-10 in DCM-a feature of autoimmune pathogenesis? Autoimmunity. 2008;41(6):478-483.
Pierson W, Liston A. A new role for interleukin-10 in immune regulation. Immunol Cell Biol. 2010;88(8):769-770.
Zhang X, Deriaud Е, Jiao Х, Braun D, Leclerc C, Lo-Man R. Type I interferons protect neonates from acute inflammation through interleukin 10-producing B cells. J Exp Med. 2007;204(5):1107-1118.
Saraiva M, O’Garra A. The regulation of IL-10 production by immune cells. Nat Rev Immunol. 2010;10(3):170-181.
Sherwin C, Broadbent R, Young S, et al. Utility of Interleukin-12 and Interleukin-10 in Comparison with Other Cytokines and Acute-Phase Reactants in the Diagnosis of Neonatal Sepsis. American Journal of Perinatology. 2008;25(10):629-636.
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