Pharmacogenetic Aspects of Airways’ Obstruction Relief Therapy of Bronchial Asthma Attacks in Schoolchildren

L.V. Mikaluk

Abstract


On the base of a complex examination of 215 schoolchildren who suffer bronchial asthma, there have been established that clinical manifestations of severity of bronchial obstructive syndrome during disease exacerbation do not depend on acetylating status. However, a homozygosity on both alleles of the glutathione transferase gene (GSTT1+M1+) has been connected to greater severity of asthma attacks, while a lack of the T-allele in children with slow acetylating phenotype has been associated with more frequent use of systemic corticosteroids and somewhat better results of airways obstruction relief therapy. Occurrence of GSTT1+M1+ genotype in patients with accelerated processes of acetylation significantly increased the risk of the inefficiency of bronchial obstruction relief therapy (odds ratio 12.4, relative risk — 6.4, the absolute risk — 50 %).


Keywords


children; bronchial asthma; gene glutathione transferase

References


Диагностика и лечение острых пневмоний и ОРВИ, осложненных БОС у детей раннего возраста / [Л.А. Безруков и соавт.]; под ред. А.Ф. Мозалевского. — Черновцы, 1989. — 23 с.

Першин Г.Н. Методы экспериментальной химиотерапии — М.: Медицина, 1971. — C. 454-457.

A genome-wide search for quantitative trait loci underlying asthma / S.E. Daniels, S. Bhattacharrya, А. James [et al.] // Nature. — 1996. — Vol. 383. — Р. 247-250.

Association of the ADAM33 gene with asthma and bronchial hyperresponsiveness / E.P. Van, R.D. Little, J. Dupuis [et al.] // Nature. — 2002. — Vol. 418. — Р. 426-430.

Effect of 17q21 variants and smoking exposure in early-onset asthma / Е. Bouzigon, Е. Corda, H.Aschard [et al.] // N. Engl. J. Med. — 2008. — Vol. 359. — Р. 1985-1994.

Genetic polymorphism of GSTM1 and antioxidant supplementation influence lung function in relation to ozone exposure in asthmatic children in Mexico City / I. Romieu, J.J. Sienra-Monge, M. Ramіrez-Aguilar [et al.] // Thorax. — 2004. — Vol. 59. —

Р. 8-10.

Glutathione S-transferase polymorphisms and colorectal cancer: a HuGE review / S.C. Cotton, L. Sharp, J. Little [et al.] // Am. J. Epidemiol. — 2000. — Vol. 151. — Р. 7-32.

Hayes J.D. The glutathione S-transferase supergene family: regulation of GST and the contribution of the isoenzymes to cancer chemoprotection and drug resistance / J.D. Hayes, D.J. Pulford // Crit. Rev. Biochem. Mol. Biol. — 1995. — Vol. 30. — Р. 445-600.

Identification of PCDH1 as a novel susceptibility gene for bronchial hyperresponsiveness / G. Koppelman, D. Meyers, Т. Howard [et al.] // Am. J. Respir. Crit. Care Med. — 2009. — Vol. 180. — Р. 929-935.

Metaanalysis of 20 genome-wide linkage studies evidenced new regions linked to asthma and atopy / Е. Bouzigon, Р. Forabosco, G.H. Koppelman [et al.] // Eur. J. Hum. Genet. — 2010. — Vol. 18. — Р. 700-706.

PLAUR polymorphisms are associated with asthma, PLAUR levels and lung function decline / S.J. Barton, G.H. Koppelman, J.M. Vonk [et al.] // J. Allergy Clin. Immunol. — 2009. — Vol. 123. — Р. 1406-1415.

Positional cloning of a quantitative trait locus on chromosome 13q14 that influences immunoglobulin E levels and asthma / Y. Zhang, N.I. Leaves, G.G. Anderson [et al.] // Nat. Genet. — 2003. — Vol. 34. — Р. 181-186.




DOI: https://doi.org/10.22141/2224-0551.2.45.2013.88222

Refbacks

  • There are currently no refbacks.


Copyright (c) 2017 CHILD`S HEALTH

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

 

© Publishing House Zaslavsky, 1997-2017

 

 Яндекс.МетрикаSeo анализ сайта Рейтинг@Mail.ru