Diagnostic and Prognostic Value of Calprotectin (MRP8/MRP14) in the Blood of Patients with Different Types of Juvenile Idiopathic Arthritis
Introduction. Determining the levels of S100A8 proteins (alias: MRP8), S100A9 (alias: MRP14) may contribute to early diagnosis of systemic arthritis in children. The objective of the study was to compare blood levels of calprotectin (MRP8/14 (S100A8/9)) in patients with systemic, polyarticular, RF-negative and oligoarticular types of juvenile idiopathic arthritis (JIA) in the active stage of the disease and to investigate the correlation between blood levels of calprotectin (MRP8/14 (S100A8/9)) with clinical and laboratory markers of JIA activity. Results. It was shown that calprotectin blood level was higher in patients with systemic course of the disease (median 13,800 ng/ml) and was significantly different from that of healthy children (median 1,800 ng/ml, p = 0.00002), indicators of patients with articular forms of JIA (median 2,700 ng/ml,
p = 0.000008), patients with polyarthritis and negative RF (median 3,800 ng/ml, p = 0.003226) and oligoarthritis (median 2,500 ng/ml, p = 0.000009). The highest calprotectin levels in the blood were found in patients with newly diagnosed systemic JIA: the median was 32,500 ng/ml (from 13,800 to 177,000 ng/ml).
A direct correlation of blood calprotectin was established with the rate of JADAS 27 blood activity (p = 0.000009), erythrocyte sedimentation rate (p = 0.000079) and C-reactive protein (p = 0.000058). Conclusions. Calprotectin level in the blood (MRP8/MRP14) (MRP8/14 (S100A8/9)) is one of the indicators that can be used to confirm the diagnosis of systemic JIA and to monitor the activity and effectiveness of therapy.
Full Text:PDF (Українська)
Foell D. Methotrexate Withdrawal at 6 vs 12 Months in Juvenile Idiopathic Arthritis in Remission: A Randomized Clinical Trial / Foell D., Wulffraat N., Wedderburn L.R. // JAMA. — 2010. — Vol. 303(13). — P. 1266-1273.
Foell D., Wittkowski H., Vogl T., Roth J. S100 proteins expressed in phagocytes: a novel group of damage-associated molecular pattern molecules // J. Leukoc. Biol. — 2007. — № 81(1). — P. 28-37.
From bench to bedside and back again: translational research in autoinflammation / Holzinger D., Kessel Ch., Omenetti A., Gattorno M. // Nat. Rev. Rheumatol. — 2015. — Vol. 11. — P. 573-585.
International League of Associations for Rheumatology classification of juvenile idiopathic arthritis: second revision, Edmonton, 2001 / Petty R.E., Southwood T.R., Manners P. et al. // J. Rheumatol. — 2004. — Vol. 31. — P. 390-392.
Kessel C. Phagocyte-derived S100 proteins in autoinflammation: putative role in pathogenesis and usefulness as biomarkers / Kessel C., Holzinger D., Foell D. // Clin. Immunol. — 2013. — Vol. 147(3). — P. 229-241.
Mrp8 and Mrp14 are endogenous activators of Toll-like receptor 4, promoting lethal, endotoxin-induced shock / Vogl T., Tenbrock K., Ludwig S. [et al.] // Nature Medicine. — 2007. — Vol. 13. — P. 1042-1049.
PReS-FINAL‑2216: Biomarkers MRP8/14 and S100A12 correspond with flare and remission clinical status in Sojia patients in the AID-NET register / Gohar F., Husmann E., Haas P.J. [et al.] // Pediatr. Rheumatol. Online J. — 2013. — Vol. 11(Suppl. 2). — P. 206.
Ravelli A. Juvenile idiopathic arthritis / Ravelli A., Martini A. // Lancet. — 2007. — Vol. 369. — P. 767-778.
S100A12 is a novel molecular marker differentiating systemiconset juvenile idiopathic arthritis from other causes of fever of unknown origin / Wittkowski H., Frosch M., Wulffraat N. [et al.] // Arthritis Rheum. — 2008. — Vol. 58(12). — P. 3924-3931.
Shenoi S. Comparison of biomarkers for systemic juvenile idiopathic arthritis / Susan Shenoi, Jing-Ni Ou, Chester Ni // Pediatric Reseach. — 2015. — Vol. 78(5). — P. 554-558.
Swart J.F. Understanding inﬂammation in juvenile idiopathic arthritis: How immune biomarkers guide clinical strategies in the systemic onset subtype / Joost F. Swart, Sytze de Roock, Berent J. Prakken // Eur. J. Immunol. — 2016. — Vol. 46. — P. 2068-2077.
The Myeloid-Related Proteins 8 and 14 Complex, a Novel Ligand of Toll-Like Receptor 4, and Interleukin‑1β Form a Positive Feedback Mechanism in Systemic-Onset Juvenile Idiopathic Arthritis / Frosch M., Ahlmann M., Vogl T. et al. // Arthritis Rheum. — 2009. — Vol. 60(3). — P. 883-891.
The Toll-like receptor 4 agonist MRP8/14 protein complex is a sensitive indicator for disease activity and predicts relapses in systemic-onset juvenile idiopathic arthritis / Holzinger D., Frosch M., Kastrup A. [et al.] // Ann. Rheum. Dis. — 2012. — Vol. 71. — P. 974-980.
- There are currently no refbacks.
Copyright (c) 2017 CHILD`S HEALTH
This work is licensed under a Creative Commons Attribution 4.0 International License.
© Publishing House Zaslavsky, 1997-2017