Usefulness of Latent Iron Deficiency Correction in the Management of Schoolchildren with Gallbladder and Sphincter of Oddi Dysfunction
Background. Rates of iron deficiency (ID) remain high among children in Ukraine. ID contributes to burdened gastrointestinal pathology in children and adolescents, but evaluation of the impact of ID correction on the biliary tract dysfunction course is currently lacking. The objective was to determine the impact of latent ID correction on the clinical course of gallbladder and sphincter of Oddi dysfunction (GSOD) and iron status in schoolchildren. Materials and methods. A case-control study was conducted in 60 children aged 9–17 years, who had been undergoing the in-patient treatment for GSOD exacerbation and had latent ID. Children were divided into 2 groups: I — 30 patients treated with iron supplementation (50 mg elemental iron) daily for 125 days; II — 30 children having no iron supplementation. The study of anamnesis, clinical examination, complete blood count, determination of serum iron, transferrin saturation calculation, hair microelement profile evaluation, follow-up for 12 month were performed. Results. The study found that the use of iron supplement in children with GSOD and latent ID not only compensates ID in them, but also facilitates the GSOD course lowering the incidence of GSOD exacerbations by 30.7 %. Conclusions. Latent ID correction with combined iron, copper and manganese gluconate supplement facilitates the clinical course of GSOD and improves iron status in schoolchildren.
World Health Organization. Iron deficiency anaemia: Assessment, prevention, and control. A guide for programme managers. — Available online: http://www.who.int/nutrition/ publications/en/ida_assessment_prevention_control.pdf (accessed on 10 August 2016)
Shadrin O.G., Hayduchyk G.A. Problems of nutrition of infants and solutions // Ukrainian Medical Journal. — III/IV 2016. — 2(112). — 68-69.
Goddard A.F., James M.W., McIntyre A.S., Scott B.B., British Soc G. Guidelines for the management of iron deficiency anaemia // Gut. — 2011. — 60. — 1309-1316. — doi: 10.1136/gut.2010.228874 [PubMed].
Mozaffari-Khosravi H., Noori-Shadkam M., Fatehi F., Naghiaee Y. Once Weekly Low-dose Iron Supplementation Effectively Improved Iron Status in Adolescent Girls // Biol. Trace Elem. Res. — 2010. — 135. — 22-30. — doi: 10.1007/s12011-009-8480-0 [PubMed].
Order of MOH Ukraine of 02.11.2015 № 709. Unified clinical protocols of primary, secondary (specialized) medical care in iron deficiency anemia (Regulations Ministry of Health of Ukraine).
Leonard A.J., Chalmers K.A., Collins C.E., Patterson A.J. Comparison of two doses of elemental iron in the treatment of latent iron deficiency: Efficacy, side effects and blinding capabilities // Nutrients. — 2014. — 6. — 1394-1405. — doi: 10.3390/nu6041394 [PubMed].
Order of MOH Ukraine of 29.01.2013 № 59. Unified clinical protocols of medical care for children with diseases of the digestive system (Regulations Ministry of Health of Ukraine).
Qayyum M., Shah M. Comparative assessment of selected metals in the scalp hair and nails of lung patients and controls // Biol. Trace Elem. Res. — 2014. — 158. — 305-322. — doi: 10.1007/s12011-014-9942-6 [PubMed].
Blanton C. Improvements in iron status and cognitive function in young women consuming beef or non-beef lunches // Nutrients. — 2013. — 6. — 90-110. — doi: 10.3390/nu6010090 [PubMed].
Peyrin-Biroulet L., Williet N., Cacoub P. Guidelines on the diagnosis and treatment of iron deficiency across indications: a systematic review // Am. J. Clin. Nutr. — 2015. — 102(6). — 1585-94. — doi: 10.3945/ajcn.114.103366 [PubMed].
Tolkien Z., Stecher L., Mander A.P., Pereira D.I., Powell J.J. Ferrous sulfate supplementation causes significant gastrointestinal side-effects in adults: a systematic review and meta-analysis // PLoS One. — 2015, Feb 20. — 10(2). — 73-83.
Marushko U.V., Nagorna K.I. Biliary dysfunction in children with iron deficiency // Zdorovie rebenka. — 2016. — 3(71). — 16-20.
Copyright (c) 2016 CHILD`S HEALTH
This work is licensed under a Creative Commons Attribution 4.0 International License.
© Publishing House Zaslavsky, 1997-2019