DOI: https://doi.org/10.22141/2224-0551.7.50.2013.84910

The Evidence Base on the Efficacy and Safety of Ibuprofen in Pediatrics

Yu.V. Marushko, Yu.I. Todyka, I.I. Garbar

Abstract


The article deals with an analysis of the world literature of recent years, the aim of which was to study the efficacy and safety of ibuprofen use as first-line antipyretic in pediatric practice. Special attention was paid to researches on the study the pharmacokinetics, efficacy and safety of ibuprofen in fever in children of all ages, as well as the use of different forms of ibuprofen (suspension, suppositories).


Keywords


ibuprofen; children; suspension; rectal suppositories; pharmacokinetics; fever

References


Марушко Ю.В., Шеф Г.Г. Невідкладна педіатрія. — К.: ФОП Сторожук О.В., 2011. — 352 с.

Kyllönen M. Perioperative pharmacokinetics of ibuprofen enantiomers after rectal administration / Kyllönen M., Olkkola K.T., Seppälä T., Ryhänen P. // Paediatr. Anaesth. — 2005. — Vol. 15, suppl. 7. — P. 566-573.

Beaver W.T. Review of the analgesic efficacy of ibuprofen // Int. J. Clin. Pract. Suppl. — 2003. — Vol. 135. — P. 13-7.

Lands L.C. High-dose ibuprofen in cystic fibrosis: Canadian safety and effectiveness trial / Lands L.C., Milner R., Cantin A.M. et al. // J. Pediatr. — 2007. — Vol. 151, Suppl. 3. — P. 249-254.

Han E.E. Pharmacokinetics of Ibuprofen in children with cystic fibrosis / Han E.E., Beringer P.M., Louie S.G. et al. // Clin. Pharmacokinet. — 2004. — Vol. 43, № 3. — P. 145-156.

Skubitz K.M. Effects of ibuprofen on chemotactic peptide-receptor binding and granulocyte response / Skubitz K.M., Hammerschmidt D.E. // Biochem. Pharmacol. — 1986. — Vol. 35. — P. 3349-3354.

Rockwell W.B. Ibuprofen in Acute-Care Therapy / W.B. Rockwell, H.P. Ehrlich // Ann. Surg. — 1990. — Vol. 211, № 1. — Р. 78-83.

Autret-Leca E. A general over view of the use of ibuprofen in paediatrics // Int. J. Clin. Pract. Suppl. — 2003. — Vol. 135. — P. 9-12.

Litalien C. Risk sand benefits of nonsteroidal anti-inflammatory drugs in children: a comparison with paracetamol / Litalien C., Jacqz-Aigrain E. // Paediatr. Drugs. — 2001. — Vol. 3, № 11. — P. 817-858.

Kauffman R.E. Effect of age on ibuprofen pharmacokinetics and antipyretic response / Kauffman R.E., Nelson M.V. // J. Pediatr. — 1992. — Vol. 121, № 6. — P. 969-973.

Brown R.D. Single-dose pharmacokinetics of ibuprofen and acetaminophen in febrile children / Brown R.D., Wilson J.T., Kearns G.L. et al. // J. Clin. Pharmacol. — 1992. — Vol. 32, № 3. — P. 231-241.

Autret E. Evaluation of ibuprofen versus aspirin and paracetamol on efficacy and comfort in children with fever / Autret E., Reboul-Marty J., Henry-Launois B. et al. // Eur. J. Clin. Pharmacol. — 1997. — Vol. 51, № 5. — P. 367-371.

Nahata M.C. Pharmacokinetics of ibuprofen in febrile children / Nahata M.C., Durrell D.E., Powell D.A., Gupta N. // Eur. J. Clin. Pharmacol. — 1991. — Vol. 40, № 4. — P. 427-428.

Moore N. Tolerability of ibuprofen, aspirin and paracetamol for the treatment of cold and flu symptoms and sore throat pain / Moore N., Le Parc J.M., van Ganse E. et al. // Int. J. Clin. Pract. — 2002. — Vol. 56, № 10. — P. 732-734.

Lesko S.M. The safety of acetaminophen and ibuprofen among children younger than two years of age / Lesko S.M., Mitchell A.A. // Pediatrics. — 1999. — Vol. 104, № 4 (www.pediatrics.org/cgi/content/full/104/4/e39).

Bjarnason I. Ibuprofen and gastrointestinal safety: a dose-duration-dependent phenomenon // J. R. Soc. Med. — 2007. — Vol. 100, Suppl. 48. — P. 11-14.

Vanden Anker J.N. Optimising the management of fever and pain in children // Int. J. Clin. Pract. Suppl. — 2013. — Vol. 178. — P. 26-32.

Ушкалова Е. Проблемы безопасности анальгетиков у детей // Врач. — 2012. — № 8. — С. 32-36.

Allan G.M. Treatment of pediatric fever. Are acetaminophen and ibuprofen equivalent? / G.M. Allan, N. Ivers, Y. Shevchuk // Canadian Family Physician. — 2010. — Vol. 56. — P. 773.

Perrott D.A. Efficacy and safety of acetaminophen vs ibuprofen for treating children’s pain or fever: a meta-analysis / Perrott D.A., Piira T., Goodenough B., Champion G.D. // Arch. Pediatr. Adolesc. Med. — 2004. — Vol. 158, № 6. — P. 521-526.

Lesko S.M., Mitchell A.A. An assessment of the safety of pediatric ibuprofen: a practitioner-based randomized clinical trial // JAMA. — 1995. — 273. — P. 929-933

Ревякина В.А. Опыт применения ибупрофена у детей с аллергическими заболеваниями // Новости медицины и фармации. — 2009. — № 5–6.

Hay A.D. Paracetamol plus ibuprofen for the treatment of fever in children (PITCH): randomised controlled trial / Hay A.D., Costelloe C., Redmond N.M. et al. // BMJ. — 2008. — Vol. 337. — P. a1302.

Paul I.M. Efficacy of standard doses of Ibuprofen alone, alternating, and combined with acetaminophen for the treatment of febrile children / Paul I.M., Sturgis S.A., Yang C. et al. // Clin. Ther. — 2010. — Vol. 32, Suppl. 14. — P. 2433-2440.

Тимченко В.Н. Нурофен для детей суппозитории ректальные в терапии различной инфекционной патологии у детей раннего возраста / Тимченко В.Н., Павлова Е.Б., Павлова Н.В. и др. // Здоровье ребенка. — 2011. — № 6(33) (http://www.mif-ua.com/archive/article/26242).

Hadas D. Premarketing surveillance of ibuprofen suppositories in febrile children / Hadas D., Youngster I., Cohen A. et al. // Clin. Pediatr. (Phila). — 2011. — Vol. 50, № 3. — P. 196-199.




Copyright (c) 2016 CHILD`S HEALTH

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

 

© Publishing House Zaslavsky, 1997-2018

 

   Seo анализ сайта