The Role of Growth Factors (VEGF, TGF-β1) and Cyclic Guanosine Monophosphate in the Formation of Pulmonary Hypertension in Children with Bronchopulmonary Dysplasia

Main Article Content

A.S. Senatorova
O.L. Logvinova


In 82 children with bronchopulmonary dysplasia (from 1 to 36 months of corrected age) we investigated the level of VEGF, TGF-β1 in blood and cyclic guanosine monophosphate (cGMP) in sputum. It was revealed that children with bronchopulmonary dysplasia had a significant increase in TGF-β1 (p < 0.05) and cGMP (p < 0.01–0.001), reduced VEGF (p < 0.05), indicating inhibition of angiogenesis, activation of fibrosis factors and endothelium-dependent vasodilation. Reliable direct dependence of activation of TGF-β1 in blood and cGMP in sputum, as well as inverse correlation between VEGF in blood and rLA had been proved, which gave reason to think of pulmonary hypertension as an adverse factor in fibrosis activation and angiogenesis inhibition in children with bronchopulmonary dysplasia. Reduced oxygen saturation and oxygen partial pressure moderately activated cGMP, but did not provide a sufficient reduction of pressure in the pulmonary artery.

Article Details

How to Cite
Senatorova, A., and O. Logvinova. “The Role of Growth Factors (VEGF, TGF-β1) and Cyclic Guanosine Monophosphate in the Formation of Pulmonary Hypertension in Children With Bronchopulmonary Dysplasia”. CHILD`S HEALTH, no. 7.50, Nov. 2013, pp. 32-36, doi:10.22141/2224-0551.7.50.2013.84886.
Clinical Pediatrics


Chen H. TGF-β receptor II in epithelia versus mesenchyme plays distinct roles in the developing lung / Zhuang F., Liu Y-H., Xu B., del Moral P., Deng W., Chai Y., Kolb M., Gauldie J., Warburton D. // Eur. Respir J. — 2008. — 32 (2). — 285-295.

Groenman F. Hypoxia-inducible Factors in the First Trimester Human Lung // Journal of Histochemistry and Cytochemistry. — 2007. — 55 (4). — 355-363.

Harkaitz B. Effects of Visual Experience on Vascular Endothelial Growth Factor Expression during the Postnatal Development of the Rat Visual Cortex Cereb // Cortex. — 2008. — 18 (7). — 1630-1639.

Morrisey E.E. Cell-Regeneration Molecules Essential Signals for Early Lung Development // Penn Medicine News. — 2009. — 3. — 45-58.

Рeacock J., Rubin L.J. Pulmonary circulation. — New York: Oxford University Press Inc., 2004. — 614.

Wigglesworth J.S. Experimental study system on fetal lung development. Influence of the central nervous // N. Engl. J. Med. — 2007. — 357. — 1190-1198.

Афанасьева Ю.И., Кузнецов С.Л., Юрина Н.А. Гистология, цитология и эмбриология. — М.: Медицина, 2006. — 765.

Most read articles by the same author(s)

1 2 3 > >>