Main Article Content
In 82 children with bronchopulmonary dysplasia (from 1 to 36 months of corrected age) we investigated the level of VEGF, TGF-β1 in blood and cyclic guanosine monophosphate (cGMP) in sputum. It was revealed that children with bronchopulmonary dysplasia had a significant increase in TGF-β1 (p < 0.05) and cGMP (p < 0.01–0.001), reduced VEGF (p < 0.05), indicating inhibition of angiogenesis, activation of fibrosis factors and endothelium-dependent vasodilation. Reliable direct dependence of activation of TGF-β1 in blood and cGMP in sputum, as well as inverse correlation between VEGF in blood and rLA had been proved, which gave reason to think of pulmonary hypertension as an adverse factor in fibrosis activation and angiogenesis inhibition in children with bronchopulmonary dysplasia. Reduced oxygen saturation and oxygen partial pressure moderately activated cGMP, but did not provide a sufficient reduction of pressure in the pulmonary artery.
This work is licensed under a Creative Commons Attribution 4.0 International License.
Our edition uses the copyright terms of Creative Commons for open access journals.
Authors, who are published in this journal, agree with the following terms:
- The authors retain rights for authorship of their article and grant to the edition the right of first publication of the article on a Creative Commons Attribution 4.0 International License, which allows others to freely distribute the published article, with the obligatory reference to the authors of original works and original publication in this journal.
- Directing the article for the publication to the editorial board (publisher), the author agrees with transmitting of rights for the protection and using the article, including parts of the article, which are protected by the copyrights, such as the author’s photo, pictures, charts, tables, etc., including the reproduction in the media and the Internet; for distributing; for the translation of the manuscript in all languages; for export and import of the publications copies of the writers’ article to spread, bringing to the general information.
- The rights mentioned above authors transfer to the edition (publisher) for the unlimited period of validity and on the territory of all countries of the world.
- The authors guarantee that they have exclusive rights for using of the article, which they have sent to the edition (publisher). The edition (the publisher) is not responsible for the violation of given guarantees by the authors to the third parties.
- The authors have the right to conclude separate supplement agreements that relate to non-exclusive distribution of their article in the form in which it had been published in the journal (for example, to upload the work to the online storage of the journal or publish it as part of a monograph), provided that the reference to the first publication of the work in this journal is included.
- The policy of the journal permits and encourages the publication of the article in the Internet (in institutional repository or on a personal website) by the authors, because it contributes to productive scientific discussion and a positive effect on efficiency and dynamics of the citation of the article.
- The rights to the article are deemed transferred by the authors to the edition (the publisher) since the moment of the publication of the article in the printed or electronic version of journal.
Chen H. TGF-β receptor II in epithelia versus mesenchyme plays distinct roles in the developing lung / Zhuang F., Liu Y-H., Xu B., del Moral P., Deng W., Chai Y., Kolb M., Gauldie J., Warburton D. // Eur. Respir J. — 2008. — 32 (2). — 285-295.
Groenman F. Hypoxia-inducible Factors in the First Trimester Human Lung // Journal of Histochemistry and Cytochemistry. — 2007. — 55 (4). — 355-363.
Harkaitz B. Effects of Visual Experience on Vascular Endothelial Growth Factor Expression during the Postnatal Development of the Rat Visual Cortex Cereb // Cortex. — 2008. — 18 (7). — 1630-1639.
Morrisey E.E. Cell-Regeneration Molecules Essential Signals for Early Lung Development // Penn Medicine News. — 2009. — 3. — 45-58.
Рeacock J., Rubin L.J. Pulmonary circulation. — New York: Oxford University Press Inc., 2004. — 614.
Wigglesworth J.S. Experimental study system on fetal lung development. Influence of the central nervous // N. Engl. J. Med. — 2007. — 357. — 1190-1198.
Афанасьева Ю.И., Кузнецов С.Л., Юрина Н.А. Гистология, цитология и эмбриология. — М.: Медицина, 2006. — 765.