The Efficacy of the Use of Probiotic Therapy in Young Children with Food Allergy

O.S. Ivakhnenko


The purpose of this study — to evaluate the efficacy of inclusion of probiotics Bifidobacterium lactis BB-12 (1 × 109 CFU) and Streptococcus thermophilus TH-4 (1 × 108 CFU) in the compbined treatment of atopic dermatitis in infants on the background of food allergy to cow’s milk protein. The study revealed that the addition of probiotics Bifidobacterium lactis BB-12 (1 × 109 CFU), and Streptococcus thermophilus TH-4 (1 × 108 CFU) for 4 weeks in infants with atopic dermatitis and proved allergy to cow’s milk protein against the elimination diet and basic treatment improves the clinical course of the disease, has a significantly positive impact on the clinical course of atopic dermatitis, reduces gastrointestinal symptoms of food allergies and has little influence on the occurrence of obstructive bronchitis.


infants; food allergy; atopic dermatitis; probiotics; cow’s milk


Holt P.G., Sly P.D., Bjorksten B. Atopic versus infectious diseases in childhood: a question of balance? // Pediatric Allergy and Immunology. — 1997. — Vol. 8. — P. 53-58.

Agostoni C., Axelsson I., Goulet O., Koletzko B., Michaelsen K. et al. Prebiotic oligosaccharides in dietetic products for infants: a commentary by the ESPGHAN Committee on Nutrition. Journal of Pediatric Gastroenterology and Nutrition // 2004. — Vol. 39. — P. 465-473.

Sampson H.A. Update on food allergy // Journal of Allergy and Clinical Immunology. — 2004. — Vol. 113. — P. 805-819.

Pediatric Nutrition in Practice / Ed. by B. Koletzko. — Basel: Karger, 2008. — 305 р.

Bjorksten B., Sepp E., Julge K., Voor T., Mikelsaar M. Allergy development and the intestinal microflora during the first year of life // J. Allergy Clin. Immunol. — 2001. — № 108(4). — P. 516-520.

Охотнікова О.М. Профілактика алергії у дітей: cучасні можливості та перспективи // Дитячий лікар. — 2011. — № 2. — С. 26-35.

Routava S., Kolliomaki M., Isolauri E. Probiotics during pregnancy and breast-feeding might confer immunomodulatory protection against atopic disease in the infant // J. Allergy Clin. Immunol. — 2002. — Vol. 109. — P. 119-121.

Pohjavuori E. et al. Lactobacillus GG effect in increasing IFN-gamma production in infants with cow’s milk allergy // J. Allergy Clin. Immunol. — 2004. — Vol. 114. — № 1. — P. 131-136.

Cukrowska B., Ceregre A., Witoslaw U. et al. The effect of novel probiotic Lactobacillus casei/paracasei strains on clinical symptoms of atopic dermatitis and serum cytokine profile in children with cows milk allergy // Book of Abstracts. 16th European Congress of Immunology. — 2006. — P. 437.

Majamaa H., Isolauri E. Probiotics: a novel approach in the management of food allergy // J. Allergy Clin. Immunol. — 1997. — Vol. 99. — P. 179-185.

Kirjavainen P.V., Salminen S.J., Isolauri E. Probiotic bacteria in the management of atopic disease: Underscoring the importance of viability // J. Pediatr. Gastroenterol. Nutr. — 2003. — Vol. 36. — P. 223-227.

Sistek D., Kelly R., Wickens K., Stanley T. et al. Is the effect of probiotics on atopic dermatitis confined to food sensitized children? // Clin. Exp. Allergy. — 2006. — Vol. 36. — P. 629-633.

Brouwer M.L., Wolt-Plompeu S.A., Dubois A.E. et al. No effects of probiotics on atopic dermatitis in infancy: a randomized placebo-controlled trial // Clin. Exp. Allergy, 2006. — Vol. 36(7). — Р. 899-906.

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