Arteriohepatic Dysplasia (Alagille Syndrome) in a Child (Clinical Case)


  • Ye.V. Omelchenko Kharkiv National Medical University
  • A.S. Senatorova Kharkiv National Medical University
  • A.F. Shipko Kharkiv National Medical University
  • A.V. Omelchenko-Seliukova Kharkiv National Medical University
  • M.N. Yermolaiev Municipal Healthcare Institution «Regional Children’s Clinical Hospital», Kharkiv, Ukraine
  • M.M. Yermolaieva Municipal Healthcare Institution «Regional Children’s Clinical Hospital», Kharkiv, Ukraine
  • Yu.A. Levchenko Municipal Healthcare Institution «Regional Children’s Clinical Hospital», Kharkiv, Ukraine



arteriohepatic dysplasia, Alagille syndrome, children.


The article presents a clinical case of a child with a rare nosology — Alagille syndrome. Among the causes of neonatal cholestasis, Alagille syndrome is ranked second, it occurs with an incidence of 1 per 70,000 of newborns. This syndrome is characterized by an insufficient number or by a small dia­meter of intrahepatic bile ducts, which carry bile from the liver. Alagille syndrome includes a combination of at least three of the five main symptoms: chronic cholestasis, cardiovascular defects, abnormalities of the spine, eye defects, typical craniofacial signs. The only definitive therapy with the formation of liver cirrhosis and without gross defects is liver transplantation.


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Pediatric Gastroenterology