Features of Motor and Secretory Disorders in Gastroesophageal Reflux Disease in Young Patients with Concomitant Obesity

O.A. Oparin, D.O. Korniienko

Abstract


The Objective of the Study. To identify the features of the motor and secretory disorders in gastroesophageal reflux disease, depending on the presence of concomitant obesity in young people.
Materials and Results of the Study. The study included 50 patients with gastroesophageal reflux disease, they we divided into 2 groups, depending on the presence of concomitant obesity. The first group included patients with gastroesophageal reflux disease and concomitant obesity, the second one — patients with gastroesophageal reflux disease without comorbidity. Control group consisted of 20 apparently healthy individuals. The study found that patients with gastroesophageal reflux disease and concomitant obesity had severe motor disturbances which were evaluated using ultrasound study (there were evaluated the diameter of esophageal hiatus, the thickness of esophageal wall, esophageal lumen width in the lower third, as well as the presence or absence of reflux), and were in close correlation with specific clinical manifestations of gastroesophageal reflux disease, measured by GERDQ questionnaires (international questionnaires for the diagnosis of gastroesophageal reflux disease) compared with the group of patients with gastroesophageal reflux disease without comorbidity.


Keywords


gastroesophageal reflux disease; obesity; motor and secretory disorders; ultrasound diagnosis

References


Boeckxstaens G., El-Serag H.B., Smout A., Kahrilas P. Symptomatic reflux disease: the present, the past and the future // BMJ. — 2014. — 63(7). — 1185-1193 // http://dx.doi.org/10.1136/gutjnl-2013-306393

Dixon J.B., Dixon M.E., O’Brien P.E. Depression in association with severe obesity: changes with weight loss // Arch. Intern. Med. — 2003. — 163. — 2058-2065. http://dx.doi.org/10.1001/archinte.163.17.2058

Friedenberg F.K., Xanthopoulos M., Foster G.D., Richter J.E. The association between gastroesophageal reflux disease and obesity // Am. J. Gastroenterol. — 2008. — 103. — 2111-2122. http://dx.doi.org/10.1111/j.1572-0241.2008.01946.x

Kahrilas P.J., Jonsson A., Denison H. et al. Impact of regurgitation on health-related quality of life in gastro–oesophageal reflux disease before and after short-term potent acid suppression therapy // Gut. — 2014. — 63. — 720-6. http://dx.doi.org/10.1136/gutjnl-2013-304883

Lim C.H., Choi M.G., Baeg M.K., Moon S.J., Kim J.S., Cho Y.K. at al. Symptom characteristics and psychosomatic profiles in different spectrum of gastroesophageal reflux disease // Gut. Liver. — 2014. — 8(2). — 165-9. http://dx.doi.org/10.5009/gnl.2014.8.2.165.

Marcowitz S., Friedman M., Arent S. Understanding the relation between obesity and depression: causal mechanisms and implications for treatment // Clin. Psychol. Sci Prac. — 2008. — 15. — 1-20. http://dx.doi.org/10.1111/j.1468-2850.2008.00106.x

Ogden C.L., Carroll M.D., Kit B.K., Flegal K.M. Prevalence of childhood and adult obesity in the United States, 2011–2012 // Journal of the American Medical Association. — 2014. — 311(8). — 806-814. http://dx.doi.org/10.1111/j.1572-0241.2008. 01946.x

Vakil N., van Zanten S.V., Kahrilas P., Dent J., Jones R. The Montreal definition and classification of gastroesophageal reflux disease: a global evidence-based consensus // Am. J. Gastroenterol. — 2006. — 101. — 1900-1920. http://dx.doi.org/10.1111/j.1572-0241.2006.00630.x

Wu Y.W., Tseng P.H., Lee Y.Ch., Wang S.Y., Chiu H.M., Tu C.H. et al. Association of Esophageal Inflammation, Obesity and Gastroesophageal Reflux Disease: From FDG PET/CT Perspective // PLoS One. — 2014. — 9(3). http://dx.doi.org/10.1371/journal.pone.0092001




DOI: https://doi.org/10.22141/2224-0551.2.1.62.1.2015.83294

Refbacks

  • There are currently no refbacks.


Copyright (c) 2016 CHILD`S HEALTH

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

 

© Publishing House Zaslavsky, 1997-2017

 

 Яндекс.МетрикаSeo анализ сайта Рейтинг@Mail.ru