The Issue of Early Diagnosis of Intestinal Complications at Antibiotic Therapy in Children
The objective of the research was to improve the timely diagnosis of intestinal complications of antibiotic therapy, caused by Clostridium difficile infection in children. We have examined 131 children aged from 6 months to 18 years who received antibiotics for microbial-inflammatory diseases. 116 of them suffered from bacterial-inflammatory diseases, which required antibiotic therapy at hospital or polyclinic; the control group consisted of 15 apparently healthy children. We have used general clinical and immunoenzyme methods.
It has been found that in children with somatic diseases, who received antibiotic treatment in hospital, acute diarrhea was the most common intestinal complication, and it has been proved that diarrhea, in most cases, is caused by Clostridium difficile infection. The incidence and clinical features of intestinal complications of antibiotic therapy in children were determined. The existence of subclinical forms of Clostridium difficile infection has been revealed. It is proved that recurrent diarrheal syndrome in children, who received repeated courses of antibacterial drugs in outpatient conditions, is also caused by Clostridium difficile infection.
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Bartlett J.G. Clostridium difficile: progress and challenges / J.G. Bartlett // Ann. N.Y. Acad. Sci. — 2010. — Vol. 1213 (1). — P. 62-69. doi: 10.1111/j.1749-6632.2010.05863.x
Clements A.C. Clostridium difficile PCR ribotype 027: assessing the risks of further worldwide spread / A.C. Clements, R.J. Magalhaes, A.J. Tatem [et al.] // Lancet Infect. Dis. — 2010. — Vol. 10 (6). — P. 395-404. doi: 10.1016/S1473-3099(10)70080-3.
Crobach M.J. European Society of Clinical Microbiology and Infectious Diseases (EСCMID): data review and recommendations for diagnosing Clostridium difficile-infection (CDI) / M.J. Crobach, O.M. Dekkers, M.H. Wilcox, E.J. Kuijper // Clin. Microbiol. Infect. — 2009. — Vol. 15. — P. 1053. doi: 10.1111/j.1469-0691.2009.03098.x.
Freeman J. The changing epidemiology of Clostridium difficile infections / J. Freeman, M.P. Bauer, S.D. Baines [et al.] // Clin. Microbiol. Rev. — 2010. — Vol. 23 (3). — P. 529-549. doi: 10.1128/CMR.00082-09
Heinlen L. Clostridium difficile infection / L. Heinlen, J.D. Ballard // Am. J. Med. Sci. — 2010. — Vol. 340 (3). — P. 247-252. doi: 10.1097/MAJ.0b013e3181e939d8
Kelly C.P. Clostridium difficile — more difficult than ever / C.P. Kelly, J.T. LaMont // N. Engl. J. Med. — 2008. — Vol. 359. — P. 1932-1940. doi: 10.1056/NEJMra0707500
Khanna S. The growing incidence and severity of Clostridium difficile infection in inpatient and outpatient settings / S. Khanna, D.S. Pardi // Expert Rev. Gastroenterol. Hepatol. — 2010. — Vol. 4. — P. 409-416. doi: 10.1586/egh.10.48.
Kim J. Epidemiological Features of Clostridium difficile-Associated Disease Among Inpatients at Children’s Hospitals in the United States, 2001–2006 / J. Kim, S. Smathers, P. Prasad [et al.] // Pediatrics. — 2008. — Vol. 122. — P. 1266-1270. doi: 10.1542/peds.2008-0469.
Lavallée C. Fatal Clostridium difficile enteritis caused by the BI/NAP1/027 strain: a case series of ileal C. difficile infections / C. Lavallée, B. Laufer, J. Pépin [et al.] // Clin. Microbiol. Infect. — 2009. — Vol. 15 (12). — P. 1093-1099. doi: 10.1111/j.1469-0691.2009.03004.x
Leclair M.A. Clostridium difficile Infection in the Intensive Care Unit / M.A. Leclair, C. Allard, O. Lesur, J. Pepin // J. Intensive Care Med. — 2010. — Vol. 25 (1). — P. 23-30. doi: 10.1177/0885066609350871.
Weiss K. Multipronged intervention strategy to control an outbreak of Clostridium difficile infection (CDI) and its impact on the rates of CDI from 2002 to 2007 / K. Weiss, A. Boisvert, M. Chagnon [et al.] // Infect. Control Hosp. Epidemiol. — 2009. — Vol. 30 (2). — P. 156-162. doi: 10.1086/593955.
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