The Efficiency of Lactobacillus Rhamnosus GG Probiotic in Complex Treatment of Food Allergy at the Background of Pancreas Pathology in Young Children

Main Article Content

K.V. Savitskaya


In recent years the prevalence of food allergy in children of younger age has become increasingly widespread. For today, secondary pancreatic insufficiency manifested by relative pancreatic insufficiency, is the second largest patho­logy caused by food allergens. The aim of the study was to prove and substantiate the efficacy of Lactobacillus Rhamnosus GG (LGG) in the combined therapy of food allergy, occurring against the background of pancreatic pathology in young children. There were observed 54 children, which were divided into two groups: the main group received complex treatment with LGG and the comparison group received traditional therapy. The results of the study indicated the beneficial effect of LGG on the clinical course of symptoms (pain, dyspeptic, asthenoneurotic symptoms), reduction of skin allergic reactions combined with functional pancreatic pathology (dysfunction of Oddi’s sphincter via the pancreatic type) with the signs of pancreatic relative insufficiency in children with food allergies. Catamnesis data indicate a longer period of remission when a treatment scheme included LGG.

Article Details

How to Cite
Savitskaya, K. “The Efficiency of Lactobacillus Rhamnosus GG Probiotic in Complex Treatment of Food Allergy at the Background of Pancreas Pathology in Young Children”. CHILD`S HEALTH, no., Oct. 2016, pp. 95-100, doi:10.22141/2224-0551.
Clinical Pediatrics


Belousov Yu. V. Pancreatitis and pancreatopathy: classification characteristics, principles of diagnosis and treatment in children / Yu.V. Belousov // Zdorov'e rebenka. – 2012. – №8(43). – Р.25 - 27.

Belousova O.Yu. The algorithm for diagnosis of pancreas diseases in children with food sensitization / O.Yu. Byelousova, Yu.V. Karpushenko// Perynatolohiya i pediatriya. – 2013. – №4(56). – Р.47-50.

Belousova O.Yu. The role of food sensitization in the development of pancreatic pathology in children / O.Yu. Byelousova, Yu.V. Karpushenko// Klinichna imunolohiya. Alerholohiya. Infektolohiya. Spetsvypusk №2. – 2013. – Р. 81-86.

Kaznacheeva L.F. Gastrointestinal form of food Allergy in children / L.F. Kaznacheeva, N.S. Yshkova, K.S. Kaznacheev // Praktycheskaya medytsyna. – 2010. – №6(10). – Р. 34-37.

Clinical Allergy & immunology: a manual for practitioners / Pod red. L.A. Horyachkynoy y K.P. Kashkyna. – M.: Praktyka, 2009 . — 432 р.

Prykaz MOZ Ukraynы # 59 ot 29.01.2013 « On approval of unified clinical protocols of medical care to children with diseases of the digestive system » - Kyev2013. – 300 р.

Consensus document of the Association of children allergists and immunologists of Russia. Primary prevention of allergies in children // Москва, 2010. – 72 р.

Boyle RJ, Robins-Browne RM, Tang ML: Probiotic use in clinical practice: what are the risks? // Am J Clin Nutr 2006, 83:1256-1264.

J. Penders E. E. Stobberingh P. A. van den Brandt1 C. Thijs and The role of the intestinal microbiota in the development of atopic disorders Article first published online: 17 AUG 2007 DOI: 10.1111/j.1398-9995.2007.01462.x.

Salminen S., Benno Y., de Vos W. Intestinal colonisation, microbiota and future probiotics? // Asia Pac. J. Clin. Nutr. — 2006; 15 (4): 558–62

Singh V, Singh K, Amdekar S, et al. Innate and specific gut-associated immunity and microbial interference.// FEMS Immunol Med Microbiol 2009;55(1):6-12.

Smehilová M, Vlková E, Nevoral J, Flajsmanová K, Killer J, Rada V. (2008) Comparison of intestinal microfora in healthy infants and infants with allergic colitis. Folia Microbiol (Praha).2008;53(3):255-8.

Van der Aa LB, Heymans HS, van Aalderen WM, Sprikkelman AB Probiotics and prebiotics in atopic dermatitis: review of the theoretical background and clinical evidence. Pediatr Allergy Immunol. 2010 Mar; 21(2 Pt 2): e355-67. doi: 10.1111/j.1399-3038.2009.00915.x. Epub 2009 Jul 2.

Verhulst SL et al. A longitudinal analysis on the association between antibiotic use, intestinal microflora, and wheezing during the first year of life. J Asthma. 2008 Nov; 45(9):828-32.

Most read articles by the same author(s)