Determination of Intestine Inflammation Markers in Diagnostic Search in Children with Intestinal Diseases
Introduction. Prevalence of bowel diseases in children is the second, trailing only the diseases of gastroduodenal zone and growing in recent years. Actual one is the problem of differential diagnosis of functional and inflammatory intestinal diseases using non-invasive methods on the prehospital stage and as a screening. Objective. Comparative analysis of fecal markers of the bowel inflammation (lactoferrine and calprotectine) with endoscopy and morphology of intestinal mucosa in children. Matherials and methods. 49 children aged 6–18 years were examined. All patients underwent endoscopic and morphological study of the intestine, coprotest, determination of fecal markers of bowel inflammation (lactoferrin and calprotectine). Results. It is shown that in young children, the intestinal mucosa mainly hadn’t endoscopic changes, coprotest and morphological examination didn’t reveal the signs of inflammation, fecal intestinal inflammation markers were negative (p < 0.05). In the group of older children, moderate or marked catarrhal changes were found endoscopically, coprotest results were typical of inflammation in the intestines, it was morphologically proved the presence of chronic inflammation of the mucous membrane of the colon with signs of atrophy, the results of lactoferrin and calprotectine determination were positive (p < 0.05). Conclusion. The findings suggest that the evaluation of calprotectine and lactoferrin can be used in pediatric patients because of its non-invasiveness as diagnostic screening for the selection of patients for the further endoscopic examination and diagnostic search.
Full Text:PDF (Українська)
Belousova O.Yu. Chronic colitis in children. – Kh., 2009. – 184 s.
Lychkovskaya O.L., Hnateyko O.Z., Yavors'kyy O.H. ta in. Role of fecal inflammatory biomarkers in differential diagnostic of organic and functional intestine diseases in children // Suchasna hastroenterolohiya – 2015. - #2 (82). – S. 28-34.
Tkach S.M. The most expected event of the year in gastroenterology: Rome Criteria IV of functional gastrointestinal disorders // Zdorov"ya Ukrayiny. Tematychnyy nomer «Hastroenterolohiya, hepatolohiya, koloproktolohiya» - 2016. - # 2 (40). – S. 24-26.
Helgeland H., Flagstad G., Grotta J. et al. Diagnosing pediatric functional abdominal pain in children (4 — 15 years old) according to the Rome III Criteria: results from a Norwegian prospective study // J. Pediatr. Gastroenterol. Nutr. — 2009. — Vol. 49. — P. 309 — 315.
Henderson P., Anderson N. A., Wilson D. C. The diagnostic accuracy of fecal calprotectin during the investigation of suspected pediatric inflammatory bowel disease: A Systematic Review and Meta-Analysis // Am. J. Gastroenterol. — 2014. — Vol. 109. — P. 637 — 645.
Joishy M., Davies I., Ahmed M. et al. Fecal calprotectin and lactoferrin as noninvasive markers of pediatric inflammatory bowel disease // J. Pediatr. Gastroenterol. Nutr. — 2009. — Vol. 48. — P. 48 — 54.
Copyright (c) 2016 CHILD`S HEALTH
This work is licensed under a Creative Commons Attribution 4.0 International License.
© Publishing House Zaslavsky, 1997-2020