Correction of pancreatic insufficiency in young children with atopic dermatitis

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I.G. Solodovnichenko
L.G. Voloshina
E.N. Babadzhanyan
E.V. Savitskaya


Introduction. Atopic dermatitis has a dominant place in the structure of the skin diseases of childhood (from 20 to 50% of patients with dermatosis children) that determines the interest of pediatricians and family doctors to improve the efficiency of treatment of this disease. Often, skin manifestations and severity are closely related to the gastrointestinal pathology, that occurs in 52% of patients with atopic dermatitis. Objective: evaluation of the effectiveness of the enzyme mini-tableted Ermital 10,000 for the compensation of pancreatic insufficiency in children with atopic dermatitis. Materials and methods. The study involved 36 children aged 3 to 6 years old with pancreatic insufficiency, against which the skin syndromes were observed in the form of atopic dermatitis. Clinical and paraclinical examination (clinical observations, scatology, the definition of IgE, amylase in serum and urine, ultrasound examination by S.I. Polyakova’s method) was performed. Results. The inclusion of pancreatin enzyme medication of Ermital 10,000 into the complex treatment of children with atopic dermatitis had a good clinical effect observed in almost 90 % of patients. In 88.8 % of children coprogram performance on the 14th day of treatment was completely normal. Conclusions. The use of the enzyme medication of Ermital 10,000 in patients with atopic dermatitis contributed to the elimination of pain and dyspeptic syndromes, improvement of laboratory parameters of the pancreas functioning, a decrease of skin manifestations. The drug is well tolerated, does not cause side effects, consequently, it can be recommended for the correction of pancreatic insufficiency in children with atopic dermatitis.

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How to Cite
Solodovnichenko, I., L. Voloshina, E. Babadzhanyan, and E. Savitskaya. “Correction of Pancreatic Insufficiency in Young Children With Atopic Dermatitis”. CHILD`S HEALTH, no., Oct. 2016, pp. 32-38, doi:10.22141/2224-0551.
Clinical Pediatrics
Author Biographies

I.G. Solodovnichenko, Kharkiv Medical Academy of Postgraduate Education, Kharkiv

Department of Pediatric Gastroenterology and Nutrition

L.G. Voloshina, Kharkiv Medical Academy of Postgraduate Education, Kharkiv

Department of Pediatric Gastroenterology and Nutrition

E.N. Babadzhanyan, Kharkiv Medical Academy of Postgraduate Education, Kharkiv

Department of Pediatric Gastroenterology and Nutrition

E.V. Savitskaya, Kharkiv Medical Academy of Postgraduate Education, Kharkiv

Department of Pediatric Gastroenterology and Nutrition


Belousov Yu V. [Pancreatitis and pancreatopathy: classification characteristics, principles of diagnosis and treatment in children]. Child Health. 2012; 8(43):129-133. Russian.

Belousova OYu, Karpushenko YuV. [Structural and functional changes of the pancreas due to the influence of food sensitization]. Zdorov"ya Ukraine.2013; 3(26):13-15. Russian.

Belousova OYu. [Pancreatic diseases in children, accompanied by the development of exocrine insufficiency: the tactics of examination and possible correction ]. Suchasna hastroenterolohiya.2014;(77): 51-58. Russian

Belousova OYu, Solodovnychenko YH. [Pangrol correction of pancreatic insufficiency in children with functional dyspepsia]. Suchasna hastroenterolohiya. 2013;6(74):48-52. Russian.

Borysova TP. [The approach to the choice of antihistamine in the treatment of allergic diseases and conditions in pediatric practice]. Zdorov'e rebenka. 2015;8(68): 33-37. Russian.

Hasylyna TV. [Diseases of the pancreas in children. Primary and secondary exocrine pancreatic insufficiency]. Lechashchyy vrach.2010;6: 6-10. Russian.

Huberhryts NB. [The possibilities of laboratory diagnosis of diseases of the pancreas]. Эksperymental'naya y klynycheskaya hastroэnterolohyya. 200; 7: 93-101. Russian.

Detskaya allerholohyya: Rukovodstvo dlya vrachey / Pod red. AA. Baranova, YY. Balabolkyna. Moscow: HЭOTAR Medya; 2006. 687p. Russian.

Zaykov SV. [Atopic dermatitis in children]. Dytyachyy likar. 2010; 2:51-58. Russian.

Kryuchko TA, Nesyna YN, Tkachenko OYa, Poda OA. [On the issue of correction of exocrine pancreatic insufficiency in children with functional and organic gastroduodenal diseases]. Zdorov'e rebenka.2016; 2(70):60-64. Ukrainian.

Lasytsa OY. [Atopic march in children: prospects for prevention and prediction]. Klynycheskaya ymmunolohyya, allerholohyya, ynfektolohyya. 2005; 1(1): 46-47. Russian.

Lymarenko MP. [Fermentopathy as a cause of cutaneous manifestations atopy in children] . Zdorov'e rebenka. 2015;2(62): 93-96. Russian.

Nahornaya NV., Lymarenko MP. [Exocrine pancreatic function and methods of evaluation]. Zdorov'e rebenka. 2012;8(43):76- 81. Russian.

Nakaz MOZ Ukrayiny # 59 vid 29.01.2013 r.[ About zatverdzhennya unіfіkovanih klіnіchnih protokolіv medichnoї Relief dіtyam іz zahvoryuvannyami organіv etching ]. Kiev;2013:143-158. Ukrainian.

Okhotnykova EN, Mellyna KV, Tkacheva TN, Volhyna YE. [Place of enzyme preparations in the treatment regimens of allergic skin diseases in children]. Sovremennaya pedyatryya. 2011;6(40):177-182. Russian.

Okhotnikova OM, Bondarenko LV, Ivanova TP. [ Gastroіntestinalnі torn down in dіtey s atopіchnim dermatitis]. Sovremennaya pedyatryya. 2014;8(64): 104-109. Ukrainian.

[Pancreatic enzymes in the treatment of atopic dermatitis in children] /NL Aryaev,YM Shevchenko,YV Kuz'menko [y dr.]. Sovremennaya pedyatryya. 2011;5(39): 200-203. Russian.

Shadrin OH, Marushko TL, Radushyns'ka TYu. [Nedostatnіst etching that yogo Roads Ahead korektsії in dіtey Rann vіku s nutritive neperenosimіstyu]. Zdorov`ya dytyny.2016;1(69):55-62. Ukrainian.

Chauhan S.[Pain management in chronic pancreatitis: A treatment algorithm] Chauhan S., Forsmark C.E. Best Pract. Res. Clin. Gastroenterol. 2010; 3(24):323-335.

Fieker A.[Enzyme replacement therapy for pancreatic insufficiency: present and future]. A. Fieker, J. Philpott, M. Armand.Clinical and Experimental Gastroenterology. 2011; 4:55-73.

Leeds JS, Oppong K., Sanders D.S. [The role of fecal elastase-1 in detecting exocrine pancreatic disease]. Nat. Rev. Gastroenterol. Hepatol.2011; 8 (7):405-415.

Siegmund E. [The diagnostic validity of non-invasive pancreatic function tests-a meta-analysis ]. Siegmund E., Lohr J.M., Schuff-Werner P. Gastroenterol. 2004:10(42):1117-1128.

Wali PD.[ Comparison of fecal elastase-1 and pancreatic function testing in children]. / Wali P.D., Loveridge-Lenza B., He Z. et al. J. Pediatr. Gastroenterol. Nutr. 2012;2(54):277-280.

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