DOI: https://doi.org/10.22141/2224-0551.5.73.2016.78321

The Antioxidant System in the Respiratory Tract The Intracellular Antioxidant Protection in the Respiratory Tract (Part 1)

A.Ye. Abaturov, A.P. Volosovets, T.P. Borysova

Abstract


The literature review presents modern data on the intracellular antioxidant protection in the respiratory tract. The induction of the enzyme synthesis of antioxidant system is described. The article details the characteristics of the intracellular forms of superoxide dismutases. The induction of the synthesis, catalytic loop and physiological function of superoxide dismutases are presented.


Keywords


antioxidant system; respiratory tract; intracellular antioxidant protection

References


Chupahin O.N. Odnoelektronnyiy perenos v organicheskoy himii // Sorosovskiy obrazovatelnyiy zhurnal. – 2001. - V. 7, № 10, - Р. 33-37.

Buettner GR, Ng CF, Wang M, Rodgers VG, Schafer FQ. A new paradigm: manganese superoxide dismutase influences the production of H2O2 in cells and thereby their biological state. Free Radic Biol Med. 2006 Oct 15;41(8):1338-50. PMID: 17015180.

Nakahira K, Haspel JA, Rathinam VA, Lee SJ, Dolinay T, Lam HC, Englert JA, Rabinovitch M, Cernadas M, Kim HP, Fitzgerald KA, Ryter SW, Choi AM. Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome. Nat Immunol. 2011 Mar;12(3):222-30. doi: 10.1038/ni.1980.

Bayir H, Kagan VE. Bench-to-bedside review: Mitochondrial injury, oxidative stress and apoptosis--there is nothing more practicalthan a good theory. Crit Care. 2008;12(1):206. doi: 10.1186/cc6779.

Biswas M1, Chan JY. Role of Nrf1 in antioxidant response element-mediated gene expression and beyond.Toxicol Appl Pharmacol. 2010 Apr 1;244(1):16-20. doi: 10.1016/j.taap.2009.07.034.

Buettner GR. Superoxide dismutase in redox biology: the roles of superoxide and hydrogen peroxide. Anticancer Agents Med Chem. 2011 May 1;11(4):341-6. PMID:21453242.

Cho HY, Kleeberger SR. Nrf2 protects against airway disorders. Toxicol Appl Pharmacol. 2010 Apr 1;244(1):43-56. doi: 10.1016/j.taap.2009.07.024.

Comhair SA, Erzurum SC. Redox control of asthma: molecular mechanisms and therapeutic opportunities. Antioxid Redox Signal. 2010 Jan;12(1):93-124. doi: 10.1089/ARS.2008.2425.

Copin JC, Gasche Y, Chan PH. Overexpression of copper/zinc superoxide dismutase does not prevent neonatal lethality in mutant mice that lack manganese superoxide dismutase.Free Radic Biol Med. 2000 May 15;28(10):1571-6. PMID: 10927183.

Case AJ, McGill JL, Tygrett LT, Shirasawa T, Spitz DR, Waldschmidt TJ, Legge KL, Domann FE. Elevated mitochondrial superoxide disrupts normal T cell development, impairing adaptive immune responses to an influenza challenge. Free Radic Biol Med. 2011 Feb 1;50(3):448-58. doi: 10.1016/j.freeradbiomed.2010.11.025.

Lindberg MJ, Normark J, Holmgren A, Oliveberg M. Folding of human superoxide dismutase: disulfide reduction prevents dimerization and produces marginally stable monomers. Proc Natl Acad Sci U S A. 2004 Nov 9;101(45):15893-8. doi: 10.1073/pnas.0403979101.

Cho HY, Reddy SP, Debiase A, Yamamoto M, Kleeberger SR. Gene expression profiling of NRF2-mediated protection against oxidative injury. Free Radic Biol Med. 2005 Feb 1;38(3):325-43. PMID: 15629862.

Kaspar JW, Niture SK, Jaiswal AK. Nrf2:INrf2 (Keap1) signaling in oxidative stress. Free Radic Biol Med. 2009 Nov 1;47(9):1304-9. doi: 10.1016/j.freeradbiomed.2009.07.035.

Kensler TW, Wakabayashi N, Biswal S. Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway.Annu Rev Pharmacol Toxicol. 2007;47:89-116. doi: 10.1146/annurev.pharmtox.46.120604.141046.

Kensler TW, Wakabayashi N. Nrf2: friend or foe for chemoprevention? Carcinogenesis. 2010 Jan;31(1):90-9. doi: 10.1093/carcin/bgp231.

Kinnula VL, Crapo JD. Superoxide dismutases in the lung and human lung diseases. Am J Respir Crit Care Med. 2003 Jun 15;167(12):1600-19. doi: 10.1164/rccm.200212-1479SO.

Landis GN, Tower J. Superoxide dismutase evolution and life span regulation. Mech Ageing Dev. 2005 Mar;126(3):365-79. doi: 10.1016/j.mad.2004.08.012.

Lane N. Oxygen: The Molecule that Made the World. - Oxford University Press; USA, 2003. - 384 P.

Leonardo CC, Doré S. Dietary flavonoids are neuroprotective through Nrf2-coordinated induction of endogenous cytoprotective proteins. Nutr Neurosci. 2011 Sep;14(5):226-36. doi: 10.1179/1476830511Y.0000000013.

Li C, Zhou HM. The role of manganese superoxide dismutase in inflammation defense. Enzyme Res. 2011;2011:387176. doi: 10.4061/2011/387176.

Maher J, Yamamoto M. The rise of antioxidant signaling—the evolution and hormetic actions of Nrf2. Toxicol Appl Pharmacol. 2010 Apr 1;244(1):4-15. doi: 10.1016/j.taap.2010.01.011.

Guo G, Yan-Sanders Y, Lyn-Cook BD, Wang T, Tamae D, Ogi J, Khaletskiy A, Li Z, Weydert C, Longmate JA, Huang TT, Spitz DR, Oberley LW, Li JJ. Manganese superoxide dismutase-mediated gene expression in radiation-induced adaptive responses. Mol Cell Biol. 2003 Apr;23(7):2362-78. PMID: 12640121.

Miao L, St Clair DK. Regulation of superoxide dismutase genes: implications in disease. Free Radic Biol Med. 2009 Aug 15;47(4):344-56. doi: 10.1016/j.freeradbiomed.2009.05.018.

Miriyala S, Holley AK, St Clair DK. Mitochondrial superoxide dismutase--signals of distinction. Anticancer Agents Med Chem. 2011 Feb;11(2):181-90. PMID: 21355846.

Lee IK, Kang KA, Zhang R, Kim BJ, Kang SS, Hyun JW. Mitochondria protection of baicalein against oxidative damage via induction of manganese superoxide dismutase. Environ Toxicol Pharmacol. 2011 Jan;31(1):233-41. doi: 10.1016/j.etap.2010.11.002.

Miyata T, Takizawa S, van Ypersele de Strihou C. Hypoxia. 1. Intracellular sensors for oxygen and oxidative stress: novel therapeutic targets. Am J Physiol Cell Physiol. 2011 Feb;300(2):C226-31. doi: 10.1152/ajpcell.00430.2010.

Nguyen T, Nioi P, Pickett CB. The Nrf2-antioxidant response element signaling pathway and its activation by oxidative stress. J Biol Chem. 2009 May 15;284(20):13291-5. doi: 10.1074/jbc.R900010200.

Niture SK, Kaspar JW, Shen J, Jaiswal AK. Nrf2 signaling and cell survival. Toxicol Appl Pharmacol. 2010 Apr 1;244(1):37-42. doi: 10.1016/j.taap.2009.06.009.

Reuter S, Gupta SC, Chaturvedi MM, Aggarwal BB. Oxidative stress, inflammation, and cancer: how are they linked?Free Radic Biol Med. 2010 Dec 1;49(11):1603-16. doi: 10.1016/j.freeradbiomed.2010.09.006.

Giovannini C, Filesi C, D'Archivio M, Scazzocchio B, Santangelo C, Masella R. Polyphenols and endogenous antioxidant defences: effects on glutathione and glutathione related enzymes. Ann Ist Super Sanita. 2006;42(3):336-47. PMID: 17124358.

Trinh CH, Hunter T, Stewart EE, Phillips SE, Hunter GJ. Purification, crystallization and X-ray structures of the two manganese superoxide dismutases from Caenorhabditis elegans. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008 Dec 1;64(Pt 12):1110-4. doi: 10.1107/S1744309108037056.

Surh YJ, Kundu JK, Na HK. Nrf2 as a master redox switch in turning on the cellular signaling involved in the induction of cytoprotective genes by some chemopreventive phytochemicals. Planta Med. 2008 Oct;74(13):1526-39. doi: 10.1055/s-0028-1088302.

Sykiotis GP, Bohmann D. Stress-activated cap'n'collar transcription factors in aging and human disease. Sci Signal. 2010 Mar 9;3(112):re3. doi: 10.1126/scisignal.3112re3.

Taguchi K, Motohashi H, Yamamoto M. Molecular mechanisms of the Keap1–Nrf2 pathway in stress response and cancer evolution. Genes Cells. 2011 Feb;16(2):123-40. doi: 10.1111/j.1365-2443.2010.01473.x.

Barra D, Schinina ME, Simmaco M, Bannister JV, Bannister WH, Rotilio G, Bossa F. The primary structure of human liver manganese superoxide dismutase. J Biol Chem. 1984 Oct 25;259(20):12595-601. PMID: 6386798.

Sykiotis GP, Habeos IG, Samuelson AV, Bohmann D. The role of the antioxidant and longevity-promoting Nrf2 pathway in metabolic regulation. Curr Opin Clin Nutr Metab Care. 2011 Jan;14(1):41-8. doi: 10.1097/MCO.0b013e32834136f2.

Perry JJ, Shin DS, Getzoff ED, Tainer JA. The structural biochemistry of the superoxide dismutases. Biochim Biophys Acta. 2010 Feb;1804(2):245-62. doi: 10.1016/j.bbapap.2009.11.004.

Borgstahl GE, Parge HE, Hickey MJ, Beyer WF Jr, Hallewell RA, Tainer JA. The structure of human mitochondrial manganese superoxide dismutase reveals a novel tetrameric interface of two 4-helix bundles.Cell. 1992 Oct 2;71(1):107-18. PMID: 1394426.

Soriano FX, Baxter P, Murray LM, Sporn MB, Gillingwater TH, Hardingham GE. Transcriptional regulation of the AP-1 and Nrf2 target gene sulfiredoxin. Mol Cells. 2009 Mar 31;27(3):279-82. doi: 10.1007/s10059-009-0050-y.

Uruno A, Motohashi H. The Keap1-Nrf2 system as an in vivo sensor for electrophiles. Nitric Oxide. 2011 Aug 1;25(2):153-60. doi: 10.1016/j.niox.2011.02.007.

Villeneuve NF, Lau A, Zhang DD. Regulation of the Nrf2-Keap1 antioxidant response by the ubiquitin proteasome system: an insight into cullin-ring ubiquitin ligases.Antioxid Redox Signal. 2010 Dec 1;13(11):1699-712. doi: 10.1089/ars.2010.3211.

Wu KC, Zhang Y, Klaassen CD. Nrf2 protects against diquat-induced liver and lung injury. Free Radic Res.2012 Oct;46(10):1220-9. doi: 10.3109/10715762.2012.700709.




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