Transient Neonatal Diabetes Associated with Chromosome 6Q24 Imprinting Abnormalities Part 4. Differential Diagnosis and Treatment

O.Ye. Abaturov, A.O. Nikulina, O.O. Rusakova, I.O. Hirina, N.M. Lybenko


The article presents the differential diagnosis of diseases that occur with neonatal hyperglycemia. The common causes of neonatal hypoglycemia, variants of its combination with clinical manifestations from the various organs and systems are indicated. There was presented an algorithm for the choice of therapeutic measures in transient neonatal diabetes mellitus (TNDM). The features of diet in newborns, insulin therapy and other directions of drug treatment were described. There was provided the information about medical funds of this syndrome, which can be used in the organization of the diagnosis and treatment in children with 6q24-TNDM.


neonatal diabetes; differential diagnosis; treatment


Kao LS et al. Hyperglycemia and morbidity and mortality in extremely low birth weight infants. J Perinatol. 2006 Dec;26(12):730-6. doi:10.1038/

Flechtner I et al. Neonatal hyperglycaemia and abnormal development of the pancreas. Best Pract Res Clin Endocrinol Metab. 2008 Feb;22(1):17-40. doi: 10.1016/j.beem.2007.08.003.

Małecki M, Skupień J. Problems in differential diagnosis of diabetes types. Pol Arch Med Wewn. 2008 Jul-Aug;118(7-8):435-40. PMID: 18714740.

Decaro MH, Vain NE. Hyperglycaemia in preterm neonates: what to know, what to do. Early Hum Dev. 2011 Mar;87 Suppl 1:S19-22. doi: 10.1016/j.earlhumdev.2011.01.005.

Sabzehei MK et al. Hyperglycemia in VLBW infants; incidence, risk factors and outcome. Arch Iran Med. 2014 Jun;17(6):429-34. doi: 014176/AIM.0010.

Bansal A et al. Glucocorticoid-induced preterm birth and neonatal hyperglycemia alter ovine beta cell development. Endocrinology. 2015 Jul 23:en20151095.

Flanagan SE et al. Mutations in ATP-sensitive K+ channel genes cause transient neonatal diabetes and permanent diabetes in childhood or adulthood. Diabetes. 2007 Jul;56(7):1930-7. doi: 10.2337/db07-0043.

Edghill EL, Flanagan SE, Ellard S. Permanent neonatal diabetes due to activating mutations in ABCC8 and KCNJ11. Rev Endocr Metab Disord. 2010 Sep;11(3):193-8. doi: 10.1007/s11154-010-9149-x.

Habeb AM et al. Permanent neonatal diabetes: different aetiology in Arabs compared to Europeans. Arch Dis Child. 2012 Aug;97(8):721-3. doi: 10.1136/archdischild-2012-301744

Greeley SA et al. Neonatal diabetes mellitus: a model for personalized medicine. Trends Endocrinol Metab. 2010 Aug;21(8):464-72. doi: 10.1016/j.tem.2010.03.004.

Naylor RN et al. Genetics and pathophysiology of neonatal diabetes mellitus. J Diabetes Investig. 2011 Jun 5;2(3):158-69. doi: 10.1111/j.2040-1124.2011.00106.x.

Rubio-Cabezas O, Ellard S. Diabetes mellitus in neonates and infants: genetic heterogeneity, clinical approach to diagnosis, and therapeutic options. Horm Res Paediatr. 2013;80(3):137-46. doi: 10.1159/000354219.

Stein SA, Maloney KL, Pollin T.I. Genetic Counseling for Diabetes Mellitus. Curr Genet Med Rep. 2014 Jun 1;2(2):56-67. doi: 10.1007/s40142-014-0039-5.

Rubio-Cabezas O et al. ISPAD Clinical Practice Consensus Guidelines 2014. The diagnosis and management of monogenic diabetes in children and adolescents. International Society for Pediatric and Adolescent Diabetes. Pediatr Diabetes. 2014 Sep;15 Suppl 20:47-64. doi: 10.1111/pedi.12192.

Demirbilek H et al. Clinical characteristics and molecular genetic analysis of 22 patients with neonatal diabetes from the South-Eastern region of Turkey: predominance of non-KATP channel mutations. Eur J Endocrinol. 2015 Jun;172(6):697-705. doi: 10.1530/EJE-14-0852.

Passanisi S et al. Treatment of transient neonatal diabetes mellitus: insulin pump or insulin glargine? Our experience. Diabetes Technol Ther. 2014 Dec;16(12):880-4. doi: 10.1089/dia.2014.0055.

Kairamkonda VR, Khashu M. Controversies in the management of hyperglycemia in the ELBW infant. Indian Pediatr. 2008 Jan;45(1):29-38. PMID: 18250502.

Smart C, Aslander-van Vliet E, Waldron S. Nutritional management in children and adolescents with diabetes. Pediatr Diabetes. 2009 Sep;10 Suppl 12:100-17. doi: 10.1111/j.1399-5448.2009.00572.x.

Karges B. Management of diabetes mellitus in infants/ B. Karges, T. Meissner, A. Icks, T. Kapellen, R.W. Holl. Nat Rev Endocrinol. 2011 Nov 29;8(4):201-11. doi: 10.1038/nrendo.2011.204.

Karp TB, Scardino C, Butler LA. Glucose metabolism in the neonate: the short and sweet of it. Neonatal Netw. 1995 Dec;14(8):17-23. PMID: 8552013.

Hume R et al. Glucose homeostasis in the newborn. Early Hum Dev. 2005 Jan;81(1):95-101. 1016/j.earlhumdev.2004 .10.005.

Milcic TL. Neonatal glucose homeostasis. Neonatal Netw. 2008 May-Jun;27(3):203-7. Doi:

Thureen PJ. Early aggressive nutrition in the neonate. Pediatr Rev. 1999 Sep;20(9):e45-55. Review. No abstract available. PMID: 10473666.

Barone JV, Tillman EM, Ferry RJ Jr. Treatment of transient neonatal diabetes mellitus with subcutaneous insulin glargine in an extremely low birth weight neonate. J Pediatr Pharmacol Ther. 2011 Oct;16(4):291-7. doi: 10.5863/1551-6776-16.4.291.

Polak M, Cavé H. Neonatal diabetes mellitus: a disease linked to multiple mechanisms. Orphanet J Rare Dis. 2007 Mar 9;2:12 doi: 10.1186/1750-1172-2-12.

Kearns GL et al. Developmental pharmacology--drug disposition, action, and therapy in infants and children. N Engl J Med. 2003 Sep 18;349(12):1157-67. doi: 10.1056/NEJMra.

Beardsall K, Pesterfield CL, Acerini CL. Neonatal diabetes and insulin pump therapy. Arch Dis Child Fetal Neonatal Ed. 2011 May;96(3):F223-4. doi: 10.1136/adc.2010.196709.

Park JH et al. Insulin pump therapy in transient neonatal diabetes mellitus. Ann Pediatr Endocrinol Metab. 2013 Sep;18(3):148-51. doi: 10.6065/apem.2013.18.3.148.

Bharucha T et al. Neonatal diabetes mellitus: Insulin pump as an alternative management strategy. J Paediatr Child Health. 2005 Sep-Oct;41(9-10):522-6. doi: 10.1111/j.1440-1754.2005.00696.x.

Tubiana-Rufi N. Insulin pump therapy in neonatal diabetes. Endocr Dev. 2007;12:67-74. PMID: 17923770.

Hoffmann A, Spengler D. Transient neonatal diabetes mellitus gene Zac1 impairs insulin secretion in mice through Rasgrf1. Mol Cell Biol. 2012 Jul;32(13):2549-60. doi: 10.1128/MCB.06637-11.

Copyright (c) 2020 O.Ye. Abaturov, A.O. Nikulina, O.O. Rusakova, I.O. Hirina, N.M. Lybenko

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.


© Publishing House Zaslavsky, 1997-2020


   Seo анализ сайта