Current Aspects of Antibiotic Therapy of Community-Acquired Pneumonia in Children of Early and Preschool Age (Review)

S.A. Mokiya-Serbina, T.V. Litviniva, A.A. Gordyeyeva


In this article we analyzed current antibiotic resistance of S.pneumoniae. We showed local (region) data on sensitivity of pneumococcus to aminopenicillins, macrolides and cephalosporines traditionally used in schemes of empirical antibiotic therapy of community-acquired pneumonia in children under 5 years. We laid basic principles of rational antibiotic therapy based on the analysis of current national and foreign guidelines on the treatment of community-acquired pneumonia. Insignificant differences in the schemes of empirical antibiotic therapy are marked due to peculiarities of local resistance of S.pneumoniae in different countries. We discussed propriety of some positions of empirical antibiotic therapy in children of early and preschool age.


children; community-acquired pneumonia; empirical antibiotic therapy


Abaturov AE, Gerasimenko ON. Features of the antibacterial therapy of respiratory infections in children. Zdorov`e rebenka. 2014;5(56):61-65. Russian

Veselov AV. Amoxicillin/clavulanate: features of pharmacokynetics and pharmacoeconomics in the treatment of respiratory infections. Gazeta “Novosti mediciny I farmacii” Allergologiya, pul’monologiya. 2009:295. Russian

Community-acquired pneumonia in children: occurrence, diagnostics, treatment and prophylactics. Nauchno-prakticheskaya programma; М: 2011 63 p. Russian

WHO, newsletter. [Internet]. [cited 2012 Nov];331. Available from: Russian

Vysochina IL, Krivusha EL, Rusakova EA. Community-acquired pneumonia in children. Zdorov'e rebenka. 2014;2(53):101-105. Russian

Geppe NA, Snegockaya MN, Evdokimov EM. Community-acquired pneumonia. Diagnostics and treatment. Praktika pediatra. 2005;10. Russian

Kozlov RS, Sivaya OV, Krechikova OI, Ivanchik NV. Dynamics of the resistance of Streptococcus pneumoniae to antibiotics in Russia in 1999-2009years. Results of multicenter prospective study PeGAS. Klin mikrobiol antimikrob himioter. 2010;12(4):329-341. Russian

Lazareva MA, Kulichenko TV, Alyab'eva NM i dr. Nasopharyngeal carriage of Streptococcus pneumoniae in children from orphanages, preschools and disorganized children under 5 years. Voprosy sovremennoj pediatrii. 2015;14(2):246-255. Russian

Majdannik VG. Community-acquired pneumonia n children. Using of azithromycin according to evidence-based medicine. Mezhdunarodnyj zhurnal pediatrii, akusherstva i ginekologii. 2012;2(1):95-111. Russian

Majdannik VG, Emchins'ka EO. Clinical guidelines of diagnostics and treatment of community-acquired pneumonia in children. К; 2013. 32 p.. Ukrainian

Majdannik VG. Clarithromycin in the treatment of low respiratory tract diseases in children. Mezhdunarodnyj zhurnal pediatrii, akusherstva i ginekologii. 2015;2:64-75. Russian

Makarova MA. Features of intensive care of necrotizing pneumonia in children. ScienceRise. 2015;7(4):78-82. Russian

Chernishova LI, Gіl'fanova AM, Bondarenko AV, ta in. Multiple antibiotic resistence of Streprococcus pneumoniae. Empirical antibacterial therapy of pneumococcal infection in children. Sovremennaya pediatriya. 2015;5:49-54. Ukrainian

Mostovoj YuM, Demchuk AV. Macrolides and allergy. Astma ta alergіya. 2015;2:53-60. Ukranian

Berezhnoj VV, Orlyuk YB, Kozachuk VG, i dr. Experience of using Flemoxin solutab in outpatient treatment of children with infections of upper and low respiratory tract. Zdorov`e Ukray`ny [Internet]. 2003;70. Available from: Russian

Strachunskij LS, Belousov YuB, Kozlov SN i dr. The practical guideline on antiinfection chemotherapy. Smolensk: MAKMAH; 2007. 464 p. Russian

Volosovets AP, Abaturov AE, Besh LV i dr. Results of multicenter study “Ceph-PROSTO” (cephpodoxima proxetil in the initial therapy of community-acquired pneumonia in children)in Ukraine. Sovremennaya pediatriya. 2011;2(36):107-112. Russian

Tatochenko VK. Flemoxin Solutab – optimal form of amoxicillin. Detskij doktor. 2001;1:42-44. Russian

Shihnebiev DA. Current antibacterial therapy of community-acuired pneumonia (review). Mezhdunarodnyj zhurnal prikladnyh i fundamental'nyh issledovanij. 2014;4:101-104. Russian

Levina AS, Babachenko IV, Sharipova EV I dr. Etiological agerelated description of community-acquired pneumonia in children. Pul’monologiya. 2014;5:62-66. Russian

Pikuza OI, Zakirova AM, Samorodnova EA, i dr. Efficacy of amoxicillin/clavulanate in care of acute community-acquired pneumonia in children. PF. 2006;5:60-62. Russian

Yulish EI, Balychevceva IV, Gadeckaya SG. Dispersible dosage form of amoxicillin in treatment of not severe community-aqcuired pneumoniain children. Zdorov'e rebenka. 2013;2:59-62. Russian

Yulish EI, Pantofel'man OYu. Macrolides in treatment of respiratory tract diseases in children caused by extracellular and cellular organisms. Zdorov'e rebenka. 2014;4:63-67. Russian

Ball P, Baquero F, Cars O et al. Consensus Group on Resistance and Prescribing in Respiratory Tract Infection. Antibiotic therapy of community respiratory tract infections: strategies for optimal outcomes and minimized resistance emergence. Journal of Antimicrobial Chemotherapy. 2002;49(1):31-40. PMID:11751764

Asada M, Yoshida M, Suzuki T, Hatachi Y, Sasaki T, Yasuda H, Nakayama K, Nishimura H, Nagatomi R, Kubo H, Yamaya M. Macrolide antibiotics inhibit respiratory syncytial virus infection in human airway epithelial cells. Antiviral Research. 2009;83(2):191-200. doi: 10.1016/j.antiviral.2009.05.003

Dagan R, Johnson C, McLinn S, Abughali N, Feris J, Leibovitz E, Burch D, Jacobs M. Bacteriologic and clinical efficacy of amoxicillin/clavulanate vs. azithromycin in acute otitis media. The Pediatric Infectious Disease Journal. 2000;19(2):95-104. PMID:10693993

Harris M, Clark N, Fletcher P, Harnden A, Mckean M, Thomson A. British Thoracic Society guidelines for the management of community-acquired pneumonia in children: update 2011. Thorax. 2011;66(Suppl 2):ii1-ii23. doi: 10.1136/thoraxjnl-2011-200598.

Comte R, Pechere J, Kohler T, Yamaguchi K, Van Delden C. Azithromycin Inhibits Quorum Sensing in Pseudomonas aeruginosa. Antimicrobial Agents and Chemotherapy. 2001;45(6):1930-1933. doi: 10.1128/AAC.45.6.1930-1933.2001

Feshchenko Y, Dzyublik F, Pertseva T, et al. Antibacterial resistance among Streptococcus pneumonia and Haemophilus influenza from Ukraine: Results from the Survey of Antibiotic Resistance (SOAR) 2011—2013. Poster presentation (P-1589). 24th ECCMID. 2014. Barselona, Spain. PMid:25823339

Franquet T. Imaging of pneumonia: trends and algorithms. European Respiratory Journal. 2001;18(1):196-208. PMID:11510793

Gielen V, Johnston S, Edwards M. Azithromycin induces anti-viral responses in bronchial epithelial cells. European Respiratory Journal. 2010;36(3):646-654. doi: 10.1183/09031936.00095809

Dwyer L, Harris-Kojetin L, Valverde R, Frazier J, Simon A, Stone N, Thompson N. Infections in Long-Term Care Populations in the United States. Journal of the American Geriatrics Society. 2013;61(3):342-349. PMID:23496650

Long S. Variability in care for children hospitalized for pneumonia: no excuses this time. The Journal of Pediatrics. 2014;165(3):427-429. doi:10.1016/j.jpeds.2014.07.015

Menendez R, Torres A, Zalacaín R Risk factors of treatment failure in community acquired pneumonia: implications for disease outcome. Thorax. 2004;59(11):960-965. doi:10.1136/thx.2003.017756

Swami S, Banerjee R. Comparison of hospital-wide and age and location - stratified antibiograms of S. aureus, E. coli, and S. pneumoniae: age- and location-stratified antibiograms. SpringerPlus. 2013;2(1):63. Available: doi: 10.1186/2193-1801-2-63

Shimizu T, Suzaki H. Past, present and future of macrolide therapy for chronic rhinosinusitis in Japan. Auris Nasus Larynx. 2015; Available:

Brown S., Farrell D. Antibacterial susceptibility among Streptococcus pneumoniae isolated from paediatric and adult patients as part of the PROTEKT US study in 2001-2002. Journal of Antimicrobial Chemotherapy. 2004;54(suppl_1):23-29. doi: 10.1093/jac/dkh311

Lassi Z, Das J, Haider S, Salam R, Qazi S, Bhutta Z. Systematic review on antibiotic therapy for pneumonia in children between 2 and 59 months of age. Archives of Disease in Childhood. 2014;99(7):687-693.

Bradley J, Byington C, Shah S, Alverson B, Carter E, Harrison C, Kaplan S, Mace S, McCracken G, Moore M, St Peter S, Stockwell J, Swanson J. The Management of Community-Acquired Pneumonia in Infants and Children Older Than 3 Months of Age: Clinical Practice Guidelines by the Pediatric Infectious Diseases Society and the Infectious Diseases Society of America. Clinical Infectious Diseases. 2011;53(7):25-76. doi: 10.1093/cid/cir531

Washington L, Palacio D. Imaging of Bacterial Pulmonary Infection in the Immunocompetent Patient. Seminars in Roentgenology. 2007;42(2):122-145. PMID:1739492

Vanhoof R, Camps K, Carpentier M, De Craeye S, Frans J, Glupczynski Y, Goffinet P, Gordts B, Govaerts D, Ide L, Lefèvre P, Lontie M, Cartuyvels R, Meunier F, Mulongo B, Philippart I, Surmont I, Van Bossuyt E, Van Eldere J, Verhaegen J. 10th Survey of antimicrobial resistance in noninvasive clinical isolates of Streptococcus pneumoniae collected in Belgium during winter 2007–2008. Pathologie Biologie. 2010;58(2):147-151. doi: 10.1016/j.patbio.2009.07.018

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