DOI: https://doi.org/10.22141/2224-0551.3.71.2016.76259

Biliary Dysfunction in Children with Iron Deficiency

Yu.V. Marushko, K.I. Nahorna

Abstract


Background. Functional disorders of the biliary tract (FDBT) remain a topical problem of pediatric gastroenterology due to the high incidence and progressive course with formation of chronic cholecystitis and cholelithiasis in patients. Iron deficiency (ID) has a well-known effect on the course of the gastrointestinal tract pathology. With the aim of evaluating the state of the biliary system and clinical features of FDBT associated with ID, a case-control study was conducted in 160 children aged 9 to 17 years, who underwent in-patient treatment for exacerbation of biliary tract pathology. According to the iron metabolism tests, children were divided into 3 groups: I — 29 children with FDBT and I degree anemia; II — 91 children with FDBT and latent ID; III — 40 children with FDBT and normal iron metabolism parameters. Research methods included: the study of anamnesis, clinical examination, complete blood count, serum iron level, total iron-binding capacity, calculation of percent transferrin saturation, ultrasound of the abdominal organs and dynamic ultrasound cholecystography with choleretic breakfast. Results. The study found that children with FDBT and ID have a higher incidence of FDBT exacerbations, increased intensity of dyspeptic and asthenovegetative symptoms in case of FDBT exacerbation, increase in size, reduced contractile function of gallbladder (GB) and hypotonic-hypokinetic FDBT type. Conclusions. Children with FDBT and ID have burdened course of FDBT due to the high incidence of exacerbations, severe dyspeptic and asthenovegetative symptoms in the acute phase, as well as reduced contractile function of GB and hypotonic-hypokinetic FDBT type, which is clinically unfavorable because of the risk of biliary sludge and cholelithiasis.


Keywords


children; functional disorders of the biliary tract; iron deficiency; iron deficiency anemia

References


Girsa V.N. [Kharakteristika variantnosti biliarnoy patologi] Vestnik Vitebskogo gosudarstvennogo meditsinskogo universiteta.2012;1:60-72. Russian

Ilchenko I.A. Delyukina O.V. [Value biliary dysfunction in the pathogenesis of cholelithiasis] Eksperimentalnaya i klinicheskaya gastroenterologiya.2011;7:70-78 Russian

Loranskaya I.D. [Functional disorders of the biliary tract].Moskow: Forte print, 2013. 92 p. Russian

Makhov V.M., Gapeeva M. B. [Dyskinetic syndrome in the pathology of the biliary tract] Russkiy meditsinskiy zhurnal. 2011;19(17):1080-1085 p. Russian

Order of MOH Ukraine from 29.01.2013 №59. Unified clinical protocols of medical care for children with diseases of the digestive system// Modern Pediatrics. - 2013. - № 4. - P. 20-31 (Regulations Ministry of Health of Ukraine)

Sebekina O.V. [The course of urticaria in patients with Helicobacter pylori-associated diseases of the upper gastrointestinal tract]: Avtoreferat dis. kand. med. nauk Moskow, 2011. 24 p. Russian

Bakoyiannis I, Gkioka E, Daskalopoulou A,. Korou LM, Perrea D, Pergialiotis V [An explanation of the pathophysiology of adverse neurodevelopmental outcomes in iron deficiency] Rev Neurosci.2015;26(4):479-88. doi: 10.1515/revneuro-2015-0012

De Andrade Cairo RC, Rodrigues Silva L, Carneiro Bustani N, Ferreira Marques CD [Iron deficiency anemia in adolescents; a literature review].Nutr Hosp.2014 Jun 1;29(6):1240-9. doi: 10.3305/nh.2014.29.6.7245. Review.PMID:24972460

Queiroz DM, Harris PR, Sanderson IR, Windle HJ, Walker MM, Rocha AM, Rocha GA, Carvalho SD, Bittencourt PF, de Castro LP, Villagrán A, Serrano C, Kelleher D, Crabtree JE [Iron status and Helicobacter pylori infection in symptomatic children: an international multi-centered study]PLoS One.2013 Jul 4;8(7):e68833. doi: 10.1371/ journal.pone.0068833. Print 2013

Yokusoglu M, Nevruz O, Baysan O, Uzun M, Demirkol S, Avcu F, Koz C, Cetin T, Hasimi A, Ural A, Isik E [The altered autonomic nervous system activity in iron deficiency anemia]. Tohoku J Exp Med.2007Aug;212(4: 397-402. PMID:17660705




Copyright (c) 2016 CHILD`S HEALTH

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

 

© Publishing House Zaslavsky, 1997-2018

 

   Seo анализ сайта