Clinical-Anamnestic Features and Evaluation of Control for Exercise-Induced Bronchial Asthma in Schoolchildren with Xenobiotics Biotransformation Genes Polymorphism

O.G. Grygola, O.K. Koloskova


Complex clinical and spirographic investigation of schoolchildren suffering from exercise-induced bronchial asthma was carried out depending on the presence or the absence of genes polymorphism of the enzymes of glutation-S-transferase — GSTT1M1. The study showed that the course of the disease was more severe in the patients with the deletions of the named genes, the reactions of hypersensitivity were more often, but the desobstructive effect during the attack was reached quicker. The self-assessment of the control of the disease by different scales showed the controversial results, but the objectification by the spirographic investigation allowed to define the risk of achieving the controlled course of the disease in children with genotype GSTT1+M1+ (odds ratio — 3.33, relative risk — 1.8, absolute risk — 29 %).


children; exercise-induced bronchial asthma; control of the disease


Глобальная стратегия лечения и профилактики бронхиальной астмы / Под ред. Чучалина А.Г. — М.: Атмосфера, 2007. — 104 с.

Наказ МОЗ України № 128 від 19.03.2007 р. «Про затвердження клінічних протоколів надання медичної допомоги за спеціальністю «пульмонологія». — Режим доступу:

Наказ МОЗ України № 767 від 27.12.2005 р. «Про затвердження протоколів діагностики та лікування алергологічних хвороб у дітей». — Режим доступу:

Сидельников В.М. Практическая аллергология детского возраста / В.М. Сидельников, Л.А. Безруков, В.Г. Мигаль. — К.: Здоровье, 1985. — С. 22-23.

Coles B.F. Human alpha class glutathione S-transferases: genetic polymorphism, expression, and susceptibility to disease / B.F. Coles, F.F. Kadlubar // Methods Enzymol. — 2005. — Vol. 401. — P. 9-42.

Development and validation of a questionnaire to measure asthma control / E.F. Juniper, P.M. O’Byrne, G.H. Guyatt [et al.] // Eur. Respir. J. — 1999. — Vol. 14(4). — P. 902-907.

Economic burden of asthma: a systematic review / K. Bahadori, M.M. Doyle-Waters, C. Marra [et al.] // BMC Pulmonary Med. — 2009. — Режим доступу:

Global strategy for asthma management and prevention (GINA, 2011) [електронний ресурс]. — Режим доступу:

Global variation in the prevalence and severity of asthma symptoms: Phase Three of the International Study of Asthma and Allergies in Childhood (ISAAC) / C.K.W. Lai, R. Beasley, J. Crane [et al.] // Thorax. — 2009. — Vol. 64. — P. 476-483.

Identification of a novel asthma susceptibility gene on chromosome 1qter andits functional evaluation / J.H. White, M. Chiano, M. Wigglesworth [et al.] // Human Molecular. Genetics. — 2008. — Vol. 17, № 13. — P. 1890-1903.

Makker A.C. Mechanisms of exercise-induced asthma / A.C. Makker, S.T. Holgate // Eur. J. Clin. Invest. — 1994. — Vol. 24. — P. 571-585.

Measuring asthma control. Clinic questionnaire or daily diary? / E.F. Juniper, P.M. O’Byrne, P.J. Ferrie [et al.] // Am. J. Respir. Crit. Care. Med. — 2000. — Vol. 162. — P. 1330-1334.

Moreira A. Exercise-induced asthma: why is it so frequent in Olympic athletes? / A. Moreira, L. Delgado, K.-H. Carlsen // Expert Rev. Resp. Med. — 2011. — Vol. 5, № 1. — P. 1-3.

National Asthma Educationand Prevention Program: Expert panel report III. Guidelines for the diagnosis and management of asthma [електронний ресурс] / National Heart, Lung, and Blood Institute. — October 2007. — Режим доступу:

Paniti S. Perception of exercise induced asthma by children and their parents / S. Panditi, M. Silverman // Arch. Dis. Child. — 2003. — № 88. — P. 807-811.

The GSTP1 gene is a susceptibility gene for childhood asthma and the GSTM1 gene is a modifier of the GSTP1 gene / F. Kamada, Y. Mashimo, H. Inoue [et al.] // Int. Arch. Allergy Immunol. — 2007. — Vol. 144, № 4. — P. 275-286.

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