Clinical and Immunological Features of Allergen-Specific Immunotherapy of Bronchial Asthma in Children

S.M. Nedelska, N.M. Taran

Abstract


The article presents the results of a study on the clinical and immunological course of bronchial asthma depending on its phenotype and duration of specific immunotherapy. It is found that allergen-specific immunotherapy with mite, epidermal and pollen allergens clinically and immunologically is a highly effective method of treatment of bronchial asthma in children. Immunotherapy with mite allergens has greater clinical efficacy than pollen and epidermal one. By immunological parameters, allergen-specific immunotherapy with epidermal allergens is more effective than with mite and pollen one, that may be associated with features of the occurrence of epidermal animal allergens in the environment. Using allergen-specific immunotherapy in the treatment of bronchial asthma allows carrying out immune rehabilitation of children who have various kinds of sensitization.

Keywords


allergen-specific immunotherapy; bronchial asthma; children; allergens.

References


Aheeva E. S. Mekhanyzmы prohrammyruemoy hybely lymfotsytov, эozynofylov y neytrofylov u bol'nыkh bronkhyal'noy astmoy / Dyssertatsyya na soyskanye nauchnoy stepeny kandydata med. nauk // h.Tomsk. - 2006h. – s.1-5

Hlobal'naya stratehyya lechenyya y profylaktyky bronkhyal'noy astmы, peresmotr 2009, 2010 hh.

Drannyk H.N. Klynycheskaya ymmunolohyya y allerholohyya. – Odessa: Astroprynt, 1999. – 603s.

Emel'yanov A.V. Spetsyfycheskaya ymmunoterapyya. // Obshchaya allerholohyya. T.1 pod red. H.B. Fedoseeva. S.-Pb., Normed-Yzdat, 2001: 682-93.

Lasytsya O.I., Nedel's'ka S.M. Spetsyfichna vaktsynatsiya alerhenamy u ditey / Metodychni rekomendatsiyi dlya likariv-interniv, likariv zahal'noyi praktyky ta likariv-alerholohiv, 2002. – 44 s.

Bousquet J, Lockey R, Mailing HJ. Aller-gen immunotherapy: therapeutic vaccines for allergic diseases. A WHO position paper.J Allergy ClinImmunol 1998;l(Pt l):558-562.

Calderon MA, Cox L, Casale TB, Moin-geon P, Demoly P. Multiple-allergen and single-allergen immunotherapy strategies in polysensitized patients: looking at the pub-lished evidence. J Allergy Clin Immunol 2012;129:929-934.

Szefler SJ, Phillips BR, Martinez FD, Chin-chilli VM, Lemanske RF, Strunk RC, et al. Characterization of within-subject responses to fluticasone and montelukast in childhood asthma.J Allergy Clin Immunol 2005; 115:233-242.

Pajno GB, Barberio G, De Luca F, Morab-ito L, Parmiani S. Prevention of new sensi-tizations in asthmatic children monosensitized to house dust mite by spe-cific immunotherapy. A six-year follow-up study.Clin Exp Allergy2001;31:1392-1397




DOI: https://doi.org/10.22141/2224-0551.7.58.2014.75782

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