Method of Acute Respiratory Infections Prevention in Children with Congenital Heart Diseases

Ye.V. Bordiuhova

Abstract


Aim: to study the efficacy and safety of liposomal recombinant interferon alpha-2β in the prevention of acute respiratory infections (ARI) in children with congenital heart disease (CHD).
Materials and Methods. In the pre-epidemic period of ARI 31 children 3–12 years old with congenital heart disease (study group) were evaluated the efficacy of a prevention program with liposomal recombinant interferon alpha-2β: 250,000 IU 1 time per day 2 times a week for 1 month (method I). Due to lack of efficacy, later prevention was continued by method II: 250,000 IU 2 times a day for 3 days, then 250,000 IU once a day, 2 times a week for one month. Clinical and laboratory examination (including assessment of the level of lysozyme, lactoferrin and secretory immunoglobulin A) was performed before the preventive effects, on the 30th, 120th, 180th day. Satisfaction with the results of prevention, side effects were assessed. The control group included 20 healthy peers.
Results. Initially children with congenital heart disease showed a reduction in oropharyngeal secretions of lysozyme, lactoferrin and secretory immunoglobulin A levels. After a prevention program by method I, we have stated a decrease in the incidence, duration and complications of ARI. Prevention program by method II showed greater efficiency on the above parameters. All children tolerated preventive treatment well, side effects were not deceted.
Conclusions. There was a reduction of local immunity parameters in children with congenital heart disease, which increases the risk of ARI morbidity. High efficiency and safety of liposomal recombinant interferon alpha-2β are the basis for its use in children to prevent ARI.


Keywords


children; congenital heart diseases; local immunity.

References


Abaturov A. E. Induktsiya molekulyarnyih mehanizmov nespetsificheskoy zaschityi respiratornogo trakta / A. E. Abaturov, A. P. Volosovets, E. I. Yulish. – K. : Privatna drukarnya Fo-P Storozhuk O. V., 2012. – 240 s.

Bazhutin N. B. Perspektivyi primeneniya liposomalnyih preparatov v meditsinskoy praktike / Bazhutin N. B., Zolin V. V, Kolokoltsov A. A., Targonskiy S. N. // Zdorove Ukrainyi. – 2007. – №3. – S.71.

Boyko N. N. Perspektivyi sovershenstvovaniya tehnologi polucheniya liposom / N. N. Boyko, A. I. Zaytsev // NanotehnologIYi u farmatsIYi ta meditsinI. MaterIali mIzhnarodnoy i naukovo-praktichnoyi konferentsiyi 13-14 zhovtnya 2011 r., m. HarkIv. – 2011. – S. 38.

Borschevskiy G. I. Standartizatsiya tehnologii izgotovleniya liposomalnoy formyi rekombinantnogo interferona alfa-2b / G. I. Borschevskiy, S. I. Dihtyarev // Farmakom. – 2009. – №3. – S. 53-58.

Grinevich A. I Etiopatogeneticheskie profilaktika i lechenie grippa i ORVI: novyie vozmozhnosti / A. I. Grinevich, V. I. Matyash // Ukr. med. chasopis. – 2011. – #4 (84) VII-VIII. – S. 20-26.

Zolyn V. V. Lyposomal'nyy protyvovyrusnyy preparat rekombynantnoho al'fa -2β ynterferona cheloveka: poluchenye y svoystva / Zolyn Vladymyr Vyktorovych …avtoref. kand. med. nauk, 03.02.02 – vyrusolohyya, Kol'tsovo – 2010. – 33 s.

Kolokoltsov A. A. Terapevticheskaya effektivnost Lipoferona liposomalnogo v profilaktike i lechenii virusnyih infektsiy / A. A. Kolokoltsov, V. V. Zolin, S. N. Targonskiy, N. B. Bazhutin // Zdorove Ukrainyi. – 2007. – №7. – S. 74-75.

Novosty medytsyny y farmatsyy. Novosty. – 2013. – №18(472). – S. 8-9, 17.

Porivnyal'ni dani pro rozpovsyudzhenist' khvorob orhaniv dykhannya i medychnu dopomohu khvorym na khvoroby pul'monolohichnoho ta alerholohichnoho profilyu v Ukrayini za 2006-2012 rr. (tablytsi): http://www.ifp.kiev.ua/doc/staff/pulmukr2012.xls .

Ryabkyna N. N. Osobennosty sotsyal'noho anamneza u detey, ymevshykh operatyvnoe vmeshatel'stvo po povodu vrozhdennoho poroka serdtsa / N. N. Ryabkyna, V. N. Shestakova, O. V. Laryonova // Vestnyk Smolenskoy medytsynskoy akademyy. – Smolensk. – 2010. – №4. – S. 53-57.

Samsyhyna H. A. Sovremennye podkhody k lechenyyu ostroy ynfektsyy respyratornoho trakta u chasto boleyushchykh detey / H. A. Samsyhyna // Pedyatryya. – 2008. – №2. – S. 99-101.

Sharyikin A. S. Vrozhdennyie poroki serdtsa. Rukovodstvo dlya pediatrov, kardiologov, neonatologov. 2-e izd. / A. S. Sharyikin – M. : Izdatelstvo BINOM, 2009. – 384 s.

Scheplyagina L. A. Mestnyiy immunitet: pediatru na zametku / L. A. Scheplyagina, I. V. Kruglova // Poliklinika. – 2011. – №6. – S. 100-101.Yulysh E. Y. Lyposomal'naya terapyya: nastoyashchee y budushchee / Yulysh E. Y., Abaturov A. E. // Zdorov'e rebenka. – 2008. – №1 (10). – S. 87-90.

Yulish E. I. Liposomalnaya terapiya: nastoyaschee i buduschee / Yulish E. I., Abaturov A. E. // Zdorove rebenka. – 2008. – №1 (10). – S. 87-90.

Yulish E. I. Metod differentsirovannogo podhoda k lecheniyu i reabilitatsii chasto i dlitelno boleyuschih respiratornyimi zabolevaniyami detey pri razlichnom techenii persistiruyuschih infektsiy / E. I. Yulish, I. V. Balyichevtseva, B. I. Krivuschev i dr. // Zdorove rebenka. – 2009. – №5(20). – S. 20-26.

Yulish E. I. Faktoryi mestnogo immuniteta pri respiratornyih infektsiyah i metodyi ih aktivatsii / E. I. Yulish // Zdorove rebenka. – 2010. – №5(26). – S. 63-67.

Dajani R. Lysozyme secretion by submucosal glands protects the airway from bacterial / R. Dajani, S. Zove, P. Taft // Ann. J. Res. Cell Mol. Biol. – 2005. – №32 (6). – R. 548-52.

Farnaud S. Lactoferrin – a multifunctional protein with antimicrobial properties / S. Farnaud, R.W. Evans // Mol. Immunol. – 2003. – №40(7). – R. 395-405.

World Health Organization (2010) EuroFlu Weekly Electronic Bulletin: www.euroflu.org/cgi-files/bulletin_v2.cgi.

Parry R., Chandon R., Shamani K. // Proc. Soc. exp. Biol. (N.Y.). – 1965. – Vol. 119 №3, P. 384.




DOI: https://doi.org/10.22141/2224-0551.7.58.2014.75776

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