DOI: https://doi.org/10.22141/2224-0551.3.63.2015.75185

Features of the Humoral Immune Response in School-age Children with Early-Onset Bronchial Asthma Depending on Acetylation Polymorphism

U.I. Marusyk

Abstract


The objective of the work was to study the individual indicators of the humoral immune system in school-age children with early-onset bronchial asthma (BA), considering acetylation phenotypes to improve treatment outcomes. There has been carried out a comprehensive examination of 34 school-age children with early-onset BA (disease first manifested at an early age). Depending on the course of the disease, patients were divided into two clinical groups. The first clinical group included 16 patients with slow acetylation (average content of acetylated sulfadimine in urine was less than 75.0 %). The second clinical group consisted of 18 pupils with fast acetylation (average level of acetylated sulfadimine in urine was over 75.0 %). All children underwent immunological blood test of II–III levels. The studies found that slow acetylation in patients with early-onset asthma increases the risk of reduction in the amount of interleukin-8 in blood serum < 5.3 pg/ml with odds ratio (OR) 4.5 (95% confident interval (CI): 2.3–8.9), as well as the risk of higher concentration of IL-4 more than 4.0 pg/ml (OR = 1.9) that is associated with atopic inflammation of the body and allows you to personalize treatment tactics in these patients.

Keywords


bronchial asthma; children; acetylation; phenotypes; interleukins.

References


World Health Organization. Bronchial asthma. Fact Sheet NE 307. – Geneva: World Health Organization, 2008.

Kim H.Y., DeKruyff R.H., Umetsu D.T. The many paths to asthma: phenotype shaped by innate and adaptive immunity. Nat. Immunol 2010; 11 (7): 577-584.

Yang I.V. Epigenetics and prenatal influences on asthma and allergic airway disease. Breath 2014; 10, 1: 25-31.

Kostromina V.P., Rechkina O.O., Mel`ny`k K.O. Risk factor for asthma in children. Astma ta alergiya 2013; 2: 21–24.

Gnatejko O.Z., Sadova O.M. Some aspects of early diagnosis of asthma in children. Zdorove rebenka 2009; 5(20):34–38.

Bragina E. Yu., Freidin M. B., Ten I. A., Ogorodova L. M. Polymorphism of xenobiotic metabolism genes of the glutathione S-transferase (GSTT1, GSTM1) and cytochrome P450 (CYP2E1 and CYP2C19) in patients with atopic bronchial asthma // Byulleten’ Sibirskogo Otdeleniya Rossiyskoy Akademii Meditsinskikh Nauk.–2005. – №13. – P. 121–125.

Tatarskyy P.F., Chumachenko N.G., Kucherenko A.M. Study on possible role of CYP1A1, GSTT1, GSTM1, GSTP1, NAT2 and ADRB2 genes polymorphisms in bronchial asthma development in children. Biopolymers and Cell 2011; 27,1: 66–73.

Barta J., Ghosh B. N-Acetyltransferases as markers for asthma and allergic. Atopic disorders current drug metabolism 2008; 9, 6: 546-553.

Ortemenka Ye.P. Significant indicators of airway hyperresponsiveness in the diagnosis of eosinophilic phenotype of asthma in children, depending on atsetilyatornogo polymorphism / Ortemenka Ye.P. // Interregional collection of scientific works with international participation (on the 70th anniversary of the Yaroslavl Medical Institute) ["Actual problems of modern pediatrics"]. – Yaroslavl`: Avers Plyus, 2014. - Р. 192-195.

Golden M.P. Leukotrienes / M.P. Golden, W.R. Henderson // The New England Journal of Medicine. – 2009. — № 357. — P. 1841—1854.

Nacak M., Aynacioglu A.S., Filiz A. Association between the N-acetylation genetic polymorphism and bronchial asthma. Br. J. Clin. Oharmacol 2002; 54 (6): 671-674.

Batra J. Sharma S.K., Ghosh B. Arylamine N-acetyltransferase gene polymorphism: markers for atopic asthma, serum Ig E and blood eosinophil counts. Molecular Biology 2009; 43 (1): 55-67.

Silvestri M., Pistorio A., Battistini E. IgE in childhood asthma: relevance of demographic characteristics and polysensitisation. Arch Dis Child 2010; 95: 979—984.

Kim H. Mazza J. Asthma. Allergy, Asthma and Clinical Immunology 2011; 7, 1: 1102-1111.




Copyright (c) 2016 CHILD`S HEALTH

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

 

© Publishing House Zaslavsky, 1997-2018

 

   Seo анализ сайта