DOI: https://doi.org/10.22141/2224-0551.1.60.2015.74936

Gastrointestinal Food Allergy in Children — Pressing Issue at Present

O.M. Okhotnikova, Yu.I. Hladush, L.V. Bondarenko, K.V. Mellina, H.M. Fedushka, T.V. Pidvyshenna, Yu.R. Borovyk, T.L. Ukraiinska, N.V. Pidhirna, O.S. Shestakova, O.F. Zarudna, O.M. Hryshсhenko

Abstract


Objective: to determine the characteristics of gastrointestinal allergy in children with allergic and somatic pathology.
Patients and Methods. 106 children were examined: study group — 60 patients with an allergy, comparison group — 46 children with digestive diseases alone. Clinical, laboratory (total immunoglobulin E) and endoscopic morphological methods were used.
Results. Cow’s milk proteins, citrus fruits, chocolate, strawberry were the most frequent causes of food allergies. Gastrointestinal symptoms in allergy manifested by pain and dyspeptic syndrome (nausea, heartburn), altered bowel elimination. 28 % of patients hadn’t abdominalgia. Blood eosinophilia has been detected in 61.7 % of children. Endoscopically, motor function was characterized by dysmotility of the stomach, esophagus or duodenum, in most cases by refluxes. Incompetence of cardia was diagnostically significant (χ2(1) = 14.095, φ = 0.374) in food allergies. Visual features of the mucous membrane (lymphoid hyperplasia, multiple small white patches) of the upper gastrointestinal tract had no significant correlation in patients from study and comparison groups (χ2 not higher than the critical value). Cases of the combination of bronchial asthma, allergic rhinitis and food allergy with normal IgE level were detected, which is caused by not-IgE-dependent reactions.
Conclusions. Endoscopic and morphological study should be applied in the differential diagnosis of allergic and non-allergic lesions of the mucous membrane of the alimentary canal.


Keywords


гастроінтестинальна алергія; ендоскопія; біопсія; імуноглобулін Е.

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Bely`czkaya M.Yu. Osobennosty` techeny`ya gastroy`ntesty`nal`nogo sy`ndroma u detej pervogo goda zhy`zny`, naxodyashhy`xsya na estestvennom vskarmly`vany`y` [Tekst] / M.Yu. Bely`czkaya,T.B. Senczova, S.N. Deny`sova, Y`.Ya. Kon`y` dr. // Rossy`jsky`j vestny`k pery`natology`y` y` pedy`atry`y`.- 2010.- # 5.- S. 45-51.

Borovy`k T.E.Mexany`zmы razvy`ty`ya py`shhevoj allergy`y` [Tekst] / T.E. Borovy`k, S.G. Gry`baky`n, S.G. Makarova y` dr. // Pedy`atry`ya. - 2011. – Tom 86, # 4. – S. 128-134.

Volosovecz A.P. Teorety`cheskoe obosnovany`e preventy`vnoj roly` ky`shechnoj my`kroby`otы v geneze allergy`chesky`x zabolevany`j u detej [Tekst] / A.P. Volosovecz, S.P. Kry`vopustov, N.T. Makuxa y` dr. // Dy`tyachy`jlikar. - 2013. - # 4 (25). – S. 5-8.

Deny`sova S.N. Dy`etoterapy`ya gastroy`ntesty`nal`nogo sy`ndroma u detej s atopy`chesky`m dermaty`tom [Tekst] / S.N. Deny`sova // Lechashhy`j vrach. - 2012. - # 4. - S. 54-55.

Kaznacheeva L.F. Gastroy`ntesty`nal`naya forma py`shhevoj allergy`y` u detej [Tekst] / L.F. Kaznacheeva // Prakty`cheskaya medy`cy`na.- 2010.- # 45.- S.88-92.

Klykova T.V. Py`shhevaya allergy`ya u detej rannego vozrasta: podxodы k dy`agnosty`ke y` lecheny`yu [Tekst] / T.V. Klыkova, E.V. Agafonova, Y`.D. Reshetny`kova // Prakty`cheskaya medy`cy`na.- 2011.- # 51.- S. 125-131.

Kruhlova L.S.Symptomokompleks dysbyoza u bol'nykh atopycheskym dermatytom y metodi eho korrektsyy [Tekst] / L.S. Kruhlova // Lechashchyy vrach. – 2012. - # 5. – S. 38-44.

Macharadze D.Sh. Atopycheskyy dermatyt y pyshchevaya allerhyya. Chto obshcheho? [Tekst] / D.Sh. Macharadze// Lechashchyy vrach. – 2013. - # 5. – S. 24-30.

Okhotnykova E.N. Hastroyntestynal'naya pyshchevaya allerhyya u detey [Tekst] / E.N. Okhotnykova // Klinichna imunolohiya. Alerholohiya. Infektolohiya.- 2013.# 2. - S. 5-13.

Okhotnykova E.N. "Allerhycheskyy marsh": svyaz' pokolenyy y эskalatsyyaallerhyy u detey[Tekst] / E.N. Okhotnykova // Klinichna imunolohiya. Alerholohiya. Infektolohiya. – 2008. - # 4 (15). – S. 7-15.

Revyakyna V.A. Pyshchevaya allerhyya, hastroyntestynal'nye proyavlenyya [Tekst] / V.A. Revyakyna // Lechashchyy vrach. – 2013. - #4.–Ts. 13-17.

Sazonova N.E. Porazhenye verkhneho otdela pyshchevarytel'noho trakta u detey doshkol'noho vozrasta s atopycheskym dermatytom y hastroyntestynal'nыmy proyavlenymy pyshchevoy allerhyy [Tekst] / N.E. Sazonova, E.Y. Shabunyna, N.Yu. Shyrokova y dr. // Pedyatryya. – 2013. – Tom 92, # 3. – S. 13-17.

Bl?zquez A.B., Mayer L., Berin M.C. Thymic stromal lymphopoietin is required for gastrointestinal allergy but not oral tolerance [Теxt] / A.D. Bl?zquez, L. Mayer, M.C. Berin // Gastroenterology.- 2010.- Vol. 139 (4).- P.1301–1309.

Bol-Schoenmakers M., et al. Regulation by intestinal gd T cells during establishment of food allergic sensitization in mice [Теxt] / [published online ahead of print September 29, 2010] // Allergy. - 2010.- P.02479.x

Can We Produce true Tolerance in Patients With Food Allergy? [Text] / M.C. Berin, L. Mayer // J. Allergy Clin. Immunol.- 2013.- Vol.131, Issue 1.-P. 14-22.

Food allergy [Text] / S.Р. Sicherer, H.A. Sampson // J. Allergy Clin. Immunol. – 2010.-Vol.125,Issue 2, Suppl. 2.-P. S354.

Mechanisms of Immune Tolerance Relevant to Food Allergy [Теxt] / B.P. Vickery, A.M. Scurlock et al. // J. Allergy Clin. Immunol. - 2011. - Vol. 127 (3). - P. 576–586.

Ostblom E., Lilja G., Pershagen G., van Hage M., Wickman M. Phenotypes of food hypersensitivity and Development of Allergic Diseases During the First 8 Years of Life [Теxt] / E. Ostblom, G. Lilja et al. // Clin Exp Allergy.- 2008.- Vol. 38.- P.1325-1332.

Robison R.G. Food Allergy [Теxt] / R.G. Robison, J.A. Pongracic // Allergy Asthma Proc.- 2012.- Vol. 33, №3. – P. 77-79.




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