Comparative Clinical and Paraclinical Analysis of Ulcerative Colitis and Crohn’s Disease in Children
DOI:
https://doi.org/10.22141/2224-0551.2.70.2016.73791Keywords:
сhildren, inflammatory bowel diseases, ulcerative colitis, Crohn’s disease, diagnosticsAbstract
Objective: to study the clinical and paraclinical features of ulcerative colitis and Crohn’s disease as a basis for improving the diagnosis of inflammatory bowel diseases in children. Materials and methods. The study included 94 children aged from 3 to 18 years with inflammatory bowel diseases. Of these, 60 patients had ulcerative colitis, 34 — Crohn’s disease. Comparative clinical and paraclinical analysis of ulcerative colitis and Crohn’s disease was performed using clinical, immunological, morphological research methods. Results. Analysis of clinical and paraclinical course of ulcerative colitis and Crohn’s disease in children showed that along with common characteristics, there were significant differences, timely detection of which helped to clarify the diagnosis, to administer adequate therapy that significantly improved the disease prognosis, improved the quality of life of the patient.
References
Bubnova LV. [Clinical and immunological features of ulcerative colitis and Crohn's disease in children: avtoref. disertation]. [Moscow]: Russian State Medical University; 2004. 21 p.
Vodylova OV, Mazankova LN, Khamer YL. [Clinical variants of Crohn's disease in children]. Ros. Vestnik perinatolohiy i pediatriy. 2005;4:18–22. Russian.
Alekseeva OP, Myronov NN, Kryshtopenko SV, Kolozets EN. [Possibilities for differential diagnosis of ulcerative colitis and Crohn's disease using HPLC serum ]. Meditsynskiy almanakh. 2010;1(10):82–84. Russian.
Vodylova OV, Kurokhtyna NS, Lebedeva SV, Mazanova LN. [Age features of clinical manifestations of Crohn's disease in children]. RMZh. 2005;13(3):173–181. Russian.
Vorob’ev HY, Khalyf YL. Voro’bev HY. Nespetsyfycheskye vospalytelnыe zabolevanyya kyshechnyka [Non-specific inflammatory bowel disease]. Moscow: Miklosh; 2008. 400 p. Russian.
Yablokova EA, Horelov MA, Ratnykova MA, et al. [Inflammatory bowel disease in children]. Pediatriya. 2006;5:99–102. Russian.
Hrona VN, Litovna VK, Hun’kin AYu. [On peculiarities of clinic and diagnostics of Crohn's disease in children]. Zdorov’e rebenka [Internet]. 2009;2(17). Available from: http://www.mif-ua.com/archive/article/8645. Russian.
Denysova MF, Cherneha NV, Beba YuV. [New opportunities in the treatment of chronic non-specific bowel disorders in children]. Sovremennaya pediatriya. 2012;4(44):153–55. Russian.
Denysova MF. [Modern approaches to the diagnosis of ulcerative colitis in children]. Sovremennaya pediatriya. 2014;3:113–15. Russian.
Denysova MF, Cherneha NV, Muzyka NN, et al. [Clinical features and efficiency of pathogenetic therapy of Crohn's disease in children]. Suchasna hastroenterolohiya. 2013;1(69):66–71. Russian.
Lyvzan MA, Makeykina MA. [Inflammatory bowel disease: modern aspects of diagnosis and treatment]. Consilium medicum. Hastroenterolohiya. 2010;2:61-65. Russian.
[Practice Guidelines World Gastroenterology Organization. Inflammatory bowel disease: a global perspective]. [Internet.] 2009;38p. Available from: www.doctor-ru.org/main/1100/1109_ru.pdf. Russian.
Rachkova NS, Khavkyn AY. [Crohn's disease]. RMZh. 2005;13(18): 1202–08. Russian.
Ryvkin VL, Kapuller LL. [The controversial and unresolved issues of differentiation of ulcerative colitis and Crohn's disease]. Consilium medicum. Hastroenterolohiya. 2012;(1):5-7. Russian.
Rumyantsev VH, Shchyholeva NE. [Crohn's disease in children]. Consilium medicum. 2002;4(6):11–17. Russian.
Tereshchenko SYu. [Crohn's disease in children and adolescents: diagnosis and modern approaches to therapy]. Pediatricheskaya farmakolohiya. 2002;6(2):40–46. Russian.
Tatyanina OF, Potapov AS, Namazova YaS, et al. [Fecal calprotectin in the non-invasive diagnosis of inflammatory bowel disease in children]. Pediatricheskaya farmakolohiya. 2008;5(3):46–54. Russian.
Shadryn OH. [Crohn's disease in children: state of the problem and the prospects of its solution in Ukraine]. Zdorov’ya Ukrayiny. Medychna hazeta. 2015;1:3–4. Russian.
Kopylov Uri, Rosenfeld Greg, Bressler Brian and Seidman Ernest. Clinical Utility of Biomarkers for the Diagnosis and Management of Inflammatory Bowel Disease. Inflamm Bowel Dis. 2014;20:742–56.
The second European evidence-based consensus on the diagnosis and management of Crohn's disease: Current management. Journal of Crohn's and Colitis. 2010;4:28–62.
Cuffari C, Darbari A. Inflammatory bowel disease in the pediatric and adolescent patient. Gastroenterol. Clin. North Am. 2002;31:275–91.
Diamanti A, Panetta F, Basso MS, et al. Diagnostic work-up of inflammatory bowel disease in children: the role of calprotectin assay. Inflamm Bowel Dis. 2010;16:1926–30.
Paul Henderson, Aoife Casey, Sally J. Zawrence. The diagnostic Accuracy of facal Calprotectin during the investiguhton of suspected Pediatric inflammatory bowel discase. Am.J.Gasrtoenterology. 2012;107:941–49.
Marshal J., Hilsden R, authors; Satsangi J, Sutherland K, editor. Environment and epidemiology of inflammatory bowel disease. Inflammatory bowel disease. Churchill–Livingstone. 2003;17–28.
Van Assche G, Dignass A, Reinisch W, et al. The second European evidence-based Consensus on the diagnosis and management of Crohn’s disease: special situation. J. Crohn’s and Colitis. 2010;4:63–101.
Update on Crohn`s disease and ulcerative colitis. Expert Rev. Gastroenterol. Hepatol. 2011;5(3):311-14.
Downloads
Published
Issue
Section
License
Copyright (c) 2016 M.F. Denysova, N.V. Cherneha, N.N. Muzyka, N.T. Reminna, I.S. Palkina, T.D. Zadorozhna, T.N. Archakova, N.Yu. Bukulova

This work is licensed under a Creative Commons Attribution 4.0 International License.
Our edition uses the copyright terms of Creative Commons for open access journals.
Authors, who are published in this journal, agree with the following terms:
- The authors retain rights for authorship of their article and grant to the edition the right of first publication of the article on a Creative Commons Attribution 4.0 International License, which allows others to freely distribute the published article, with the obligatory reference to the authors of original works and original publication in this journal.
- Directing the article for the publication to the editorial board (publisher), the author agrees with transmitting of rights for the protection and using the article, including parts of the article, which are protected by the copyrights, such as the author’s photo, pictures, charts, tables, etc., including the reproduction in the media and the Internet; for distributing; for the translation of the manuscript in all languages; for export and import of the publications copies of the writers’ article to spread, bringing to the general information.
- The rights mentioned above authors transfer to the edition (publisher) for the unlimited period of validity and on the territory of all countries of the world.
- The authors guarantee that they have exclusive rights for using of the article, which they have sent to the edition (publisher). The edition (the publisher) is not responsible for the violation of given guarantees by the authors to the third parties.
- The authors have the right to conclude separate supplement agreements that relate to non-exclusive distribution of their article in the form in which it had been published in the journal (for example, to upload the work to the online storage of the journal or publish it as part of a monograph), provided that the reference to the first publication of the work in this journal is included.
- The policy of the journal permits and encourages the publication of the article in the Internet (in institutional repository or on a personal website) by the authors, because it contributes to productive scientific discussion and a positive effect on efficiency and dynamics of the citation of the article.
- The rights to the article are deemed transferred by the authors to the edition (the publisher) since the moment of the publication of the article in the printed or electronic version of journal.