Main Article Content
Background. The problem of gastrointestinal diseases in children remains quite relevant due to the high prevalence and presence of atypical symptoms and comorbidities pathogenetically associated with acid-dependent diseases. The purpose was to study the dynamics of inflammatory changes of the mucous membrane in children with duodenal ulcer (DU). Materials and methods. One hundred and six children aged 10 to 18 years with DU were examined. To verify the diagnosis, all children underwent endoscopy, pH-metry, morphological examination of gastrobiopsy samples, examination for Helicobacter pylori (H.pylori). Results. 49.1 % of children with DU were diagnosed with impaired motor-evacuatory function in the form of duodenogastric and/or gastrooesophageal reflexes, 81.1 % of patients presented with H.pylori was determined. Erythematous changes of the gastric and duodenal mucosa predominated. 92.4 % of patients were diagnosed with chronic non-atrophic gastritis and/or gastroduodenitis with varying degrees of inflammation, 7.6 % of children — chronic atrophic gastritis. There was a decrease in height and signs of desquamation of the superficial epithelium, in 72.3 % — the development of granular dystrophy, in 6.9 % of patients without H.pylori infection and in 57.5 % of H.pylori infected — neutrophilic infiltration of the mucous membrane. In the dynamics after 3 months, the height of the superficial epithelium and the frequency of desquamative changes decreased, and the proliferation of the glandular epithelium 12.4 % increased. Conclusions. Morphological changes in biopsies of the gastric mucosa differ depending on the presence of H.pylori infection and partially persist for 3 months after treatment.
This work is licensed under a Creative Commons Attribution 4.0 International License.
Our edition uses the copyright terms of Creative Commons for open access journals.
Authors, who are published in this journal, agree with the following terms:
- The authors retain rights for authorship of their article and grant to the edition the right of first publication of the article on a Creative Commons Attribution 4.0 International License, which allows others to freely distribute the published article, with the obligatory reference to the authors of original works and original publication in this journal.
- Directing the article for the publication to the editorial board (publisher), the author agrees with transmitting of rights for the protection and using the article, including parts of the article, which are protected by the copyrights, such as the author’s photo, pictures, charts, tables, etc., including the reproduction in the media and the Internet; for distributing; for the translation of the manuscript in all languages; for export and import of the publications copies of the writers’ article to spread, bringing to the general information.
- The rights mentioned above authors transfer to the edition (publisher) for the unlimited period of validity and on the territory of all countries of the world.
- The authors guarantee that they have exclusive rights for using of the article, which they have sent to the edition (publisher). The edition (the publisher) is not responsible for the violation of given guarantees by the authors to the third parties.
- The authors have the right to conclude separate supplement agreements that relate to non-exclusive distribution of their article in the form in which it had been published in the journal (for example, to upload the work to the online storage of the journal or publish it as part of a monograph), provided that the reference to the first publication of the work in this journal is included.
- The policy of the journal permits and encourages the publication of the article in the Internet (in institutional repository or on a personal website) by the authors, because it contributes to productive scientific discussion and a positive effect on efficiency and dynamics of the citation of the article.
- The rights to the article are deemed transferred by the authors to the edition (the publisher) since the moment of the publication of the article in the printed or electronic version of journal.
Tishchenko DV, Matveeva OV, Chernenkov YuV, Maslyakova GN, Bucharskaya AB. Clinical and morphological characteristics of chronic duodenitis in children. Saratov Journal of Medical Scientific Research. 2012;8(3):799-803. (in Russian).
Bobrova VI, Vorobienko JI, Koshova AO. Morphological and functional features of chronic gastroduodenal pathology pathology in children, who smoke. International journal of pediatrics, obstetrics and gynecology. 2013;4(2):34-38. (in Ukrainian).
Burkitt MD, Duckworth CA, Williams JM, Pritchard DM. Helicobacter pylori-induced gastric pathology: insights from in vivo and ex vivo models. Dis Model Mech. 2017 Feb 1;10(2):89-104. doi:10.1242/dmm.027649.
Bertaux-Skeirik N, Feng R, Schumacher MA, et al. CD44 plays a functional role in Helicobacter pylori-induced epithelial cell proliferation. PLoS Pathog. 2015 Feb 6;11(2):e1004663. doi:10.1371/journal.ppat.1004663.
Panarese A, Galatola G, Armentano R, et al. Helicobacter pylori-induced inflammation masks the underlying presence of low-grade dysplasia on gastric lesions. World J Gastroenterol. 2020 Jul 14;26(26):3834-3850. doi:10.3748/wjg.v26.i26.3834.
Mera RM, Bravo LE, Camargo MC, et al. Dynamics of Helicobacter pylori infection as a determinant of progression of gastric precancerous lesions: 16-year follow-up of an eradication trial. Gut. 2018 Jul;67(7):1239-1246. doi:10.1136/gutjnl-2016-311685.
Gonciarz W, Krupa A, Hinc K, et al. The effect of Helicobacter pylori infection and different H. pylori components on the proliferation and apoptosis of gastric epithelial cells and fibroblasts. PLoS One. 2019 Aug 7;14(8):e0220636. doi:10.1371/journal.pone.0220636.
Sun H, Yuan H, Tan R, et al. Immunodominant antigens that induce Th1 and Th17 responses protect mice against Helicobacter pylori infection. Oncotarget. 2018 Jan 3;9(15):12050-12063. doi:10.18632/oncotarget.23927.
Dixon MF, Genta RM, Yardley JH, Correa P. Classification and grading of gastritis. The updated Sydney System. International Workshop on the Histopathology of Gastritis, Houston 1994. Am J Surg Pathol. 1996 Oct;20(10):1161-1181. doi:10.1097/00000478-199610000-00001.