Dynamics of inflammatory changes of the gastric mucosa in children with duodenal ulcer

Main Article Content

T.V. Sorokman
P.M. Moldovan
L.Yu. Khlunovska
I.Ya. Lozyuk


Background. The problem of gastrointestinal diseases in children remains quite relevant due to the high prevalence and presence of atypical symptoms and comorbidities pathogenetically associated with acid-dependent diseases. The purpose was to study the dynamics of inflammatory changes of the mucous membrane in children with duodenal ulcer (DU). Materials and methods. One hundred and six children aged 10 to 18 years with DU were examined. To verify the diagnosis, all children underwent endoscopy, pH-metry, morphological examination of gastrobiopsy samples, examination for Helicobacter pylori (H.pylori). Results. 49.1 % of children with DU were diagnosed with impaired motor-evacuatory function in the form of duodenogastric and/or gastrooesophageal reflexes, 81.1 % of patients presented with H.pylori was determined. Erythematous changes of the gastric and duodenal mucosa predominated. 92.4 % of patients were diagnosed with chronic non-atrophic gastritis and/or gastroduodenitis with va­rying degrees of inflammation, 7.6 % of children — chronic atrophic gastritis. There was a decrease in height and signs of desquamation of the superficial epithelium, in 72.3 % — the development of granular dystrophy, in 6.9 % of patients without H.pylori infection and in 57.5 % of H.pylori infected — neutrophilic infiltration of the mucous membrane. In the dynamics after 3 months, the height of the superficial epithelium and the frequency of desquamative changes decreased, and the proliferation of the glandular epithelium 12.4 % increased. Conclusions. Morphological changes in biopsies of the gastric mucosa differ depending on the presence of H.pylori infection and partially persist for 3 months after treatment.

Article Details

How to Cite
Sorokman, T., P. Moldovan, L. Khlunovska, and I. Lozyuk. “Dynamics of Inflammatory Changes of the Gastric Mucosa in Children With Duodenal Ulcer”. CHILD`S HEALTH, vol. 16, no. 4, Sept. 2021, pp. 285-8, doi:10.22141/2224-0551.16.4.2021.236907.
Clinical Pediatrics


Stepanov YuM, Skirda IYu, Petishko OP. Digestive system diseases: the actual problem of clinical medicine. Gastroenterologìa. 2019;53(1):1-6. doi:10.22141/2308-2097.53.1.2019.163450. (in Ukrainian).

Shekera OG, Melnyk DV. The prevalence of diseases among children digestive and peptic ulcer disease duodenum - urgent problem of family medicine. Family Medicine. 2017;(69):16-20. (in Ukrainian).

Melnik DV. Peptic ulcer of children of school age (Review of the literature). Family Medicine. 2018;(77):125-129. (in Ukrainian).

Tishchenko DV, Matveeva OV, Chernenkov YuV, Maslyakova GN, Bucharskaya AB. Clinical and morphological characteristics of chronic duodenitis in children. Saratov Journal of Medical Scientific Research. 2012;8(3):799-803. (in Russian).

Bobrova VI, Vorobienko JI, Koshova AO. Morphological and functional features of chronic gastroduodenal pathology pathology in children, who smoke. International journal of pediatrics, obstetrics and gynecology. 2013;4(2):34-38. (in Ukrainian).

Baj J, Forma A, Sitarz M, et al. Helicobacter pylori Virulence Factors-Mechanisms of Bacterial Pathogenicity in the Gastric Microenvironment. Cells. 2020 Dec 25;10(1):27. doi:10.3390/cells10010027.

Burkitt MD, Duckworth CA, Williams JM, Pritchard DM. Helicobacter pylori-induced gastric pathology: insights from in vivo and ex vivo models. Dis Model Mech. 2017 Feb 1;10(2):89-104. doi:10.1242/dmm.027649.

Bertaux-Skeirik N, Feng R, Schumacher MA, et al. CD44 plays a functional role in Helicobacter pylori-induced epithelial cell proliferation. PLoS Pathog. 2015 Feb 6;11(2):e1004663. doi:10.1371/journal.ppat.1004663.

Panarese A, Galatola G, Armentano R, et al. Helicobacter pylori-induced inflammation masks the underlying presence of low-grade dysplasia on gastric lesions. World J Gastroenterol. 2020 Jul 14;26(26):3834-3850. doi:10.3748/wjg.v26.i26.3834.

Mera RM, Bravo LE, Camargo MC, et al. Dynamics of Helicobacter pylori infection as a determinant of progression of gastric precancerous lesions: 16-year follow-up of an eradication trial. Gut. 2018 Jul;67(7):1239-1246. doi:10.1136/gutjnl-2016-311685.

Panarese A, Shahini E, Pesce F, Caruso ML. P1839 Detection of lesions in Helicobacter Pylori gastritis before and after eradication by expert endoscopists. UEG J. 2018;6(Suppl 8):A734. 

Gonciarz W, Krupa A, Hinc K, et al. The effect of Helicobacter pylori infection and different H. pylori components on the proliferation and apoptosis of gastric epithelial cells and fibroblasts. PLoS One. 2019 Aug 7;14(8):e0220636. doi:10.1371/journal.pone.0220636.

Gobert AP, Wilson KT. Human and Helicobacter pylori Interactions Determine the Outcome of Gastric Diseases. Curr Top Microbiol Immunol. 2017;400:27-52. doi:10.1007/978-3-319-50520-6_2.

Sgouras DN, Trang TT, Yamaoka Y. Pathogenesis of Helicobacter pylori Infection. Helicobacter. 2015 Sep;20 Suppl 1(0 1):8-16. doi:10.1111/hel.12251.

Sun H, Yuan H, Tan R, et al. Immunodominant antigens that induce Th1 and Th17 responses protect mice against Helicobacter pylori infection. Oncotarget. 2018 Jan 3;9(15):12050-12063. doi:10.18632/oncotarget.23927.

Joo M. Rare Gastric Lesions Associated with Helicobacter pylori Infection: A Histopathological Review. J Pathol Transl Med. 2017 Jul;51(4):341-351. doi:10.4132/jptm.2017.04.03.

Dixon MF, Genta RM, Yardley JH, Correa P. Classification and grading of gastritis. The updated Sydney System. International Workshop on the Histopathology of Gastritis, Houston 1994. Am J Surg Pathol. 1996 Oct;20(10):1161-1181. doi:10.1097/00000478-199610000-00001.

Most read articles by the same author(s)

1 2 3 > >>