Crohn’s disease in children: actual aspects of diagnosis and treatment according to modern international guidelines
Keywords:Crohn’s disease, diagnosis, treatment, children, review
The article summarizes the knowledge about epidemiological data, clinical features, modern principles of diagnosis and treatment of Crohn’s disease in children based on the analysis of literature sources using paper and electronic databases PubMed, CyberLeninka, Web of Science, MedLine, The Cochrane Library. A review of literary sources on the study of this pathology demonstrates that at the present stage, the diagnosis of inflammatory bowel diseases, especially in young children, is still a complicated issue. The article focused on the complexity of the diagnostic search due to the not always typical course of the disease in childhood. Data are presented on the peculiarities of clinical course of the disease depending on localization of the pathological process. The author emphasizes the importance of early diagnosis of Crohn’s disease in order to provide immediate protocol treatment and the need for detecting this pathology already at the level of primary medical care. The article also presents data of the European Society for Paediatric Gastroenterology, Hepatology and Nutrition and the European Crohn’s and Colitis Organisation on the necessary scope of methods for the diagnosis of Crohn’s disease in children according to the current international guidelines. The review describes the modern principles of treatment of Crohn’s disease in children, the main pharmacological groups of drugs that have a proven evidence base in pediatric practice. Particular attention is paid to the role of total enteral nutrition as the safest and quite effective direction of the initial therapy for this pathology in children. In conclusion, the author considered the problem of differential diagnosis of inflammatory bowel disease in pediatric practice.
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