Pathomorphological features of clinical forms of ulcerative colitis in children

Authors

  • M.F. Denysova State Institution “Lukianova Institute of Pediatrics, Obstetrics and Gynecology of the National Academy of Medical Sciences of Ukraine”, Kyiv, Ukraine https://orcid.org/0000-0001-5243-7675
  • T.D. Zadorozhna State Institution “Lukianova Institute of Pediatrics, Obstetrics and Gynecology of the National Academy of Medical Sciences of Ukraine”, Kyiv, Ukraine
  • N.Yu. Bukulova State Institution “Lukianova Institute of Pediatrics, Obstetrics and Gynecology of the National Academy of Medical Sciences of Ukraine”, Kyiv, Ukraine
  • T.М. Archakova State Institution “Lukianova Institute of Pediatrics, Obstetrics and Gynecology of the National Academy of Medical Sciences of Ukraine”, Kyiv, Ukraine

DOI:

https://doi.org/10.22141/2224-0551.16.1.2021.226445

Keywords:

ulcerative colitis, children, clinical picture, structure of the colon mucosa

Abstract

Background. Ulcerative colitis is a chronic inflammatory disease of unknown origin, characterized by a clinically recurrent course with periods of bloody diarrhea and pathomorpholo­gical-diffuse inflammatory process in the colon. The problem of ulcerative colitis requires further study of the clinical features of the disease, taking into account the localization, degree of activity of the inflammatory process, changes in the structure of the mucous membrane that will help increase the efficiency of ulcerative colitis diagnosis in childhood. Materials and methods. On the basis of clinical and statistical analysis of 116 case histories of children aged 4–18 years with ulcerative colitis, the features of its clinical forms — total, segmental and distal — were studied during the period of exacerbation of the disease. Four hundred and forty-five biopsy specimens obtained during colonoscopy were histologically examined. After biopsy sampling, specimens were fixed in 10% formalin and were processed according to the generally accepted histological method with section staining using hematoxylin-eosin and according to Van Gieson. Results. Changes in the architecto­nics of the large intestine mucosa, which reduce the resistance of the mucous barrier, as well as impaired blood supply — a factor in the development of hemic hypoxia — are significant for the mechanisms of ulcerative colitis exacerbation.

References

Birg TM, Selivanova LS, Sharoian ZhV, Tertychnyi AS. Endoscopic and morphological comparisons in inflammatory bowel diseases. Koloproktologia. 2015;51(Suppl 1):97-98. (in Russ ian).

Vasilenko IV. Morphological diagnosis of nonspecific ulcerative colitis. Novosti Meditsiny i Farmatsii. Gastroenterologia. 2010;(313):37-43. (in Russian).

Gonchar MO, Riga OO, Muratov GR, Kichtenko OV, Orlova NV. Ulcerative colitis in children of an early age: symptoms and diagnostics (Case report). Young Scientist. 2018;7(59):189-193. (in Russian).

Horobets AO. Unspecific ulcerative colitis in children. Perinatologiya i pediatriya. 2015;(61):74-80. doi:10.15574/PP.2015.61.74. (in Ukrainian).

Denysova MF. Ulcerative colitis and children - a difficult issue for diagnosis and treatment. Zdorov’ja Ukrai'ny. Pediatrija. 2020;(52):10-11. (in Ukrainian).

Denysova MF, Cherneha NV, Muzyka NN, et al. Comparative Clinical and Paraclinical Analysis of Ulcerative Colitis and Crohn’s Disease in Children. Zdorov`e rebenka. 2016;(70):10-15. doi:10.22141/2224-0551.2.70.2016.73791. (in Russian).

Denysova MF, Muzyka NN, Cherneha NV, Zadorozhna TD, Archakova TM, Bukulova NYu. Peculiarities of the course of ulcerative colitis in children at the present stage. Zdorov`e rebenka. 2017;12(2):136-141. doi:10.22141/2224-0551.12.2.2017.99769. (in Ukrainian).

Klyaritskaya IL, Moshko YA, Viltsanyuk IA. New approaches to the assessment of biopsies in inflammatory bowel disease. KTJ. 2014;(2):38-60. (in Russian).

Kornienko EA, Mazankova LN, Gorelov AV, Shikh ES, Namazova-Baranova LS, Beliaeva IA. Application of probiotics in pediatrics: analysis of their therapeutic and preventive effect from the point of view of evidence-based medicine. Lechaschii Vrach. 2015;(9):52-61. (in Russian).

Kornienko EA, Krupina AN, Gabrusskaya TV, Kalinina NM. Inflammatory bowel disease with a very early onset. Almanac of Clinical Medicine. 2016;44(6):719-733. doi:10.18786/2072-0505-2016-44-6-719-733. (in Russian).

Orlinskaya NYu, Shirokova NYu, Shumilova OV, Davydova DA, Davydenko DV, Sokolova IL. The importance of morphological studies in case of inflammatory bowel diseases in children. Medical Almanac. 2018;(54):31-35. (in Russian).

Stepanov YuM, Skyrda IYu, Petishko OP. Chronic inflammatory bowel disease: peculiarity of epidemiology in Ukraine. Gastroenterologìa. 2017;51(2):97-105. doi:10.22141/2308-2097.51.2.2017.101703. (in Ukrainian).

Olén O, Askling J, Sachs MC, et al. Increased Mortality of Patients With Childhood-Onset Inflammatory Bowel Diseases, Compared With the General Population. Gastroenterology. 2019 Feb;156(3):614-622. doi:10.1053/j.gastro.2018.10.028.

Roberts SE, Thorne K, Thapar N, et al. A Systematic Review and Meta-analysis of Paediatric Inflammatory Bowel Disease Incidence and Prevalence Across Europe. J Crohns Colitis. 2020 Sep 7;14(8):1119-1148. doi:10.1093/ecco-jcc/jjaa037.

World Gastroenterology Organisation (WGO). Inflammatory Bowel Disease: World Gastroenterology Organisation Global Guidelines. Update August 2015. Milwaukee, WI: WGO; 2015. 36 p.

Yerushalmy-Feler A, Singer D, Berkovitch G, et al. Predictors for poor outcome of hospitalized children with inflammatory bowel disease. Eur J Pediatr. 2020 Jan;179(1):157-164. doi:10.1007/s00431-019-03491-9.

Published

2021-04-06

Issue

Section

Clinical Pediatrics