Risk factors for ulcerative colitis in children

N.Yu. Bukulova


Background. Inflammatory bowel disease is one of the pressing problems in pediatric gastroenterology, due to the rapid spread of this pathology, displacement in the onset of the disease at an early age of a child (the first three years of life), the formation of severe complications, low efficiency of modern treatment regimens. The problem of ulcerative colitis in children requires further comprehensive study, including risk factors of the emergence of disease that will enable the formation of risk groups for the deve­lopment of the disease, rationale for the preventive measures for the notification. Materials and methods. Study of risk factors was conducted by interviewing 100 mothers whose children suffered from ulcerative colitis. The control group consisted of 30 mothers of healthy children. Results. Based on mathematical analysis of biomedical risk factors for the development for ulcerative colitis in children, the most significant are identified as follows: burdened heredity for diseases of the digestive system, intestinal dysfunctions at an early age, repeated courses of antibiotic therapy, se­condary lactase deficiency, frequent respiratory diseases. The algorithm was developed for predicting ulcerative colitis in childhood as well as the well-grounded approaches to the prevention of this pathology.


ulcerative colitis; children; risk factors


Belousova OIu. Risk factors for the development of chronic non-specific non-ulceral colitis in children. Zdorovʹe rebenka. 2008;(12):2–8. (in Russian).

Volodin NN. Perinatal medicine: problems, ways and conditions of their solution. Pediatria. 2004;83(5):18–29. (in Russian).

World Health Organization (WHO); Regional Office for Europe. Available from:

Glavnov PV, Lebedeva NN, Kashchenko VA, Varzin SA. Ulcer colitis and Crohn’s disease: current state of a problem of an etiology, early diagnostics and treatment (review of literature). Vestnik of Saint Petersburg University. Medicine. 2015;(4):48–72. (in Russian).

Gubler EV, Genkin AA. Primenenie neparametricheskikh kriteriev statistiki v mediko-biologicheskikh issledovaniiakh [Application of nonparametric statistical criteria in biomedical research]. SPb: Meditsina; 1973. 144 p. (in Russian).

Denisova MF. Intestinal diseases. In: Luk'ianova EM, editor. Spravochnik detskogo gastroenterologa [Handbook of pediatric gastroenterologist]. Kyiv: Zdorov'e; 1985. 102–121 pp. (in Russian).

Dorofeeva A. Morphological features of the mucous membrane of the colon of patients with early and late ulcerative colitis debut. Visnyk of Taras Shevchenko National University of Kyiv. 2019;(26):12–17. (in Ukrainian).

Kiku PF, Zhigaev DS, Shiter NS, Sabirova KM, Mezentseva MA. The concept of risk factors for the health of the population. Biulleten' fiziologii i patologii dykhaniia. 2016;(62):101–109. (in Russian).

Lysana TO, Denisova MF, Chernega NV, et al. State of biocenosis of intestines in children with ulcerative colitis. Problems of uninterrupted medical training and science. 2019;(33):8–12. (in Ukrainian).

Mukvich OM, Lavrenchuk OV, Gridina TA, Poluk TA. Clinical picture of chronic gastroduodenitis in children with connective tissue dysplasia. Perinatologiya i pediatriya. 2015;(61):81. (in Russian).

Radushyns'ka TJu. Optymizacija diagnostyky ta likuvannja hronichnoi' diarei', obumovlenoi' laktaznoju nedostatnistju u ditej rann'ogo viku. Diss. kand. med. nauk [Optimization of the diagnosis and treatment of chronic diarrhea due to lactase deficiency in young children. PhD in Med Sci diss.]. Kyiv; 2018. 18 p. (in Ukrainian).

Rumiantsev VG. Iazvennyi kolit u detei: rukovodstvo dlia vrachei [Ulcerative colitis in children: a guide for doctors]. Moscow; 2009. 20–24 pp. (in Russian).

Smishhuk VV, Slobodjanjuk OV, Koshova AO. Priority directions for genetic research in children with cholelethiasis and risk groups. Ukrayins'kyy naukovo-medychnyy molodizhnyy zhurnal. 2012;(1):218. (in Ukrainian).

Shadrin OG, Platonova OM. Pediatric aspects of the diagnosis and treatment of functional disorders of the gastrointestinal tract. Practical medicine. 2011;(54):25–27. (in Ukrainian).

Shadrin OG, Zadorozhnaya TD, Berezenko VS, et al. Features of the course and differential diagnosis in infants with chronic diarrhea. Perinatologiya i pediatriya. 2018;(79):105–110. (in Russian).

Shadrin OG, Marushko RV, Bryuzgina TS, et al. Functional food and chronic colitis in infants. Sovremennaya pediatriya. 2010;(34):82–86. (in Russian).

Ahmad T, Satsangi J, McGovern D, Bunce M, Jewell DP. Review article: the genetics of inflammatory bowel disease. Aliment Pharmacol Ther. 2001;15(6):731–748. doi:10.1046/j.1365-2036.2001.00981.x.

Ashton Ja, Batra A, Beattie RM. Paediatric inflammatory bowel disease- brief update on current practice. Paediatrics and Child Health. 2018;28(11):507–514. doi: 10.1016/j.paed.2018.08.007.

Hviid A, Svanström H, Frisch M. Antibiotic use and inflammatory bowel diseases in childhood. Gut. 2011;60(1):49–54. doi:10.1136/gut.2010.219683.

Orholm M, Munkholm P, Langholz E, Nielsen OH, Sørensen TI, Binder V. Familial occurrence of inflammatory bowel disease. N Engl J Med. 1991;324(2):84–88. doi:10.1056/NEJM199101103240203.

Putowski M, Padala O, Krupa A, Konopelko M, Piasek E, Mazurek M. Inflammatory bowel disease in children. J Educ Health Sport. 2019;9(8):406–411. doi:10.5281/zenodo.3379040.

Russel MG, Pastoor CJ, Janssen KM, et al. Familial aggregation of inflammatory bowel disease: a population-based study in South Limburg, The Netherlands. The South Limburg IBD Study Group. Scand J Gastroenterol Suppl. 1997;223:88–91.

Santos MPC, Gomes C, Torres J. Familial and ethnic risk in inflammatory bowel disease. Ann Gastroenterol. 2018;31(1):14–23. doi:10.20524/aog.2017.0208.

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