Drug therapy of autonomic dysfunction in children
The literature review gives general ideas about disorders of the autonomic nervous system, or autonomic dysfunction, in childhood. Autonomic dysfunction syndrome is one of the most common pathologies among the child population, which occurs in every third child, and in 17–20 % of children over the course of age can become the basis for the development of arterial hypertension, coronary heart disease, bronchial asthma, and frequent respiratory infections. Late diagnosis and inadequate treatment of autonomic dysfunction can lead to a significant decrease in the quality of life and the development of neuropsychiatric and somatic diseases. Treatment of autonomic dysfunction syndrome requires an integrated and individual approach in each case. The use of herbal preparations is one of the effective and safe methods of drug treatment for autonomic dysfunction in children and adolescents. Many clinical trials using a phytopreparation that contains taurine, a thick extract of motherwort (Leonurus cardiaca), a thick extract of hawthorn fruit (Crataegus oxyacantha L.) for the treatment of autonomic dysfunction in children have shown a sufficient efficacy and safety of its use. The effect of therapy for autonomic dysfunction in children with the drug, which includes taurine, a thick extract of motherwort (Leonurus cardiaca), a thick extract of hawthorn fruit (Crataegus oxyacantha L.), on the state of the cardiovascular system is characterized by: normalization of heart rate, systolic, diastolic and average blood pressure, normalization of the circadian rhythm (an increase in the number of children with a normal circadian type of blood pressure — dippers), a decrease in the risk of non-paroxysmal tachycardia, restoration of the pacemaker’s excitability, reduction of the manifestation of the syndrome of early ventricular repolarization. Thus, a phytopreparation that contains taurine, a thick motherwort extract (Leonurus cardiaca), a thick extract of hawthorn fruit (Crataegus oxyacantha L.) can be considered the drug of primary choice in the treatment of autonomic dysfunction syndrome, which is accompanied by a tendency to develop hypertension.
Full Text:PDF (Українська)
Borysova TP, Abaturov AE. Clinical manifestations and correction of autonomic dysfunction in children and adolescents. Zdorovʹe rebenka. 2018;13(6):588–594. doi:10.22141/2224-0522.214.171.1248.143165. (in Russian).
Volkova IV. Features of the immune system of 8-14 years-old children with somatoform dysfunction of the autonomic nervous system, often suffering from recurrent infection. International Journal of Medicine and Psychology. 2019;2(4):39–42. (in Russian).
Zakharova IN, Tvorogova TM, Pshenichnikova II. Current guidelines for diagnosis and treatment of vegetative dystonia in children and adolescents. Meditsinskiy sovet. 2016;(16):116–123. doi:10.21518/2079-701X-2016-16-116-123. (in Russian).
Kvashnina LV, Ignatova TB, Maydan IS. Timely correction of vegetative homeostasis disorders is the prevention of hypertension development among the children. Sovremennaya Pediatriya. 2019;(97):102–110. doi:10.15574/SP.2019.97.102. (in Russian).
Kvashnina LV, Ignatova TB, Rodionov VP, Makovkina YuA, Skobenko OV. Еxperience of using preparation “Kratal for children” for children with neurocirculatory and vegeto-vascular forms of vegetative dysfunction by the results of clinical trial in four messages (Message 1). Perinatologiya i Pediatriya. 2012;(50):14. (in Russian).
Kvashnina LV, Ignatova TB, Rodionov VP, Makovkina YuA, Skobenko OV. Efficiency of application of the preparation "Kratal for children" for children with neurocirculatory and vegeto-vascular dysfunction forms by results of research of the vegetative homeostasis (Message 2). Perinatologiya i Pediatriya. 2012;(52):48–52. (in Russian).
Kvashnina LV, Ignatova TB, Rodionov VP, Makovkina YuA, Skobenko OV. Experience of the use of "Kratal for kids" in children with neurocirculatory and vegetative-vascular forms of vegetative dysfunction by the results of clinical studies in 4 reports (Report 3). Perinatologiya i Pediatriya. 2013;(5):28. (in Russian).
Kvashnina LV, Ignatova TB, Rodionov VP, Makovkina YuA, Skobenko OV. Еxperience of using preparation "Kratal for children" for children with neurocirculatory and vegetovascular forms of vegetative dysfunction by the results of clinical trial in four messages (Message 4). Perinatologiya i Pediatriya. 2013;(54):32. (in Russian).
Maidannyk VG, Smiyan OI, Bynda TP, Savelieva-Kulyk NO, authors; Maidannyk VG, editor. Kliniko-patogenetychna harakterystyka vegetatyvnyh dysfunkcij ta i'h likuvannja u ditej: navchal'nyj posibnyk [Clinical and pathogenetic characteristics of autonomic dysfunctions and their treatment in children: a training manual]. Sumy: SumDU; 2013. 173 p. (in Ukrainian).
Mikhieieva TM, Nechytailo DYu, Poniuk VV, Fomina TP. Features of the vegetative state and arterial pressure level in children with chronic gastroduodenal pathology. Zaporozhye Medical Journal. 2018;20(110):651–654. doi:10.14739/2310-1210.2018.5.141662. (in Ukrainian).
Pankov DD, Neudakhin EV, Moreno IG. Somatoformnye rasstroistva i vegetososudistaia distoniia u detei i podrostkov [Somatoform disorders and vegetovascular dystonia in children and adolescents]. Moscow; 2019. 69 p. (in Russian).
Chutko LS, Kornishina TL, Surushkina SYu, Yakovenko EA, Anisimova TI, Volov MB. Syndrome of autonomic dysfunction in children and adolescents. Zhurnal nevrologii i psikhiatrii imeni SS Korsakova. 2018;118(1):43–49. doi: 10.17116/jnevro20181181143-49. (in Russian).
Afsheen N, Khalil-Ur-Rehman, Jahan N, et al. Cardioprotective and Metabolomic Profiling of Selected Medicinal Plants against Oxidative Stress. Oxid Med Cell Longev. 2018;2018:9819360. doi:10.1155/2018/9819360.
Ahmadian M, Dabidi Roshan V, Ashourpore E. Taurine Supplementation Improves Functional Capacity, Myocardial Oxygen Consumption, and Electrical Activity in Heart Failure. J Diet Suppl. 2017;14(4):422–432. doi:10.1080/19390211.2016.1267059.
Benmalek Y, Yahia OA, Belkebir A, Fardeau ML. Anti-microbial and anti-oxidant activities of Illicium verum, Crataegus oxyacantha ssp monogyna and Allium cepa red and white varieties. Bioengineered. 2013;4(4):244–248. doi:10.4161/bioe.24435.
Brixius K, Willms S, Napp A, et al. Crataegus special extract WS 1442 induces an endothelium-dependent, NO-mediated vasorelaxation via eNOS-phosphorylation at serine 1177. Cardiovasc Drugs Ther. 2006;20(3):177–184. doi:10.1007/s10557-006-8723-7.
Costa R, Occhiuto F, Circosta C. Comparison of young shoots, leaves and flowers of Crataegus oxyacantha for cardiovascular activity. III. Protective effect on isolated rat heart against arrhythmia-inducing agents and in reperfusion arrhythmias. Plantes Med Phytother. 1986;(20):115–128.
Degenring FH, Suter A, Weber M, Saller R. A randomised double blind placebo controlled clinical trial of a standardised extract of fresh Crataegus berries (Crataegisan) in the treatment of patients with congestive heart failure NYHA II. Phytomedicine. 2003;10(5):363–369. doi:10.1078/0944-7113-00312.
Dong Y, Liao J, Yao K, Jiang W, Wang J. Application of Traditional Chinese Medicine in Treatment of Atrial Fibrillation. Evid Based Complement Alternat Med. 2017;2017:1381732. doi:10.1155/2017/1381732.
Ginguay A, De Bandt JP, Cynober L. Indications and contraindications for infusing specific amino acids (leucine, glutamine, arginine, citrulline, and taurine) in critical illness. Curr Opin Clin Nutr Metab Care. 2016;19(2):161–169. doi:10.1097/MCO.0000000000000255.
Hellenbrecht D, Saller R, Ruckbeil C, Buhring M. Randomized placebo-controlled study with Crataegus on exercise tests and challenge by catecholamines in healthy subject. Eur J Pharmacol. 1990;183(2):525–526. doi:10.1016/0014-2999(90)93428-S.
Ito T, Yoshikawa N, Inui T, Miyazaki N, Schaffer SW, Azuma J. Tissue depletion of taurine accelerates skeletal muscle senescence and leads to early death in mice. PLoS One. 2014;9(9):e107409. doi:10.1371/journal.pone.0107409.
Ito T, Yoshikawa N, Schaffer SW, Azuma J. Tissue taurine depletion alters metabolic response to exercise and reduces running capacity in mice. J Amino Acids. 2014;2014:964680. doi:10.1155/2014/964680.
Jakaria M, Azam S, Haque ME, et al. Taurine and its analogs in neurological disorders: Focus on therapeutic potential and molecular mechanisms. Redox Biol. 2019;24:101223. doi:10.1016/j.redox.2019.101223.
Jayalakshmi R, Thirupurasundari CJ, Devaraj SN. Pretreatment with alcoholic extract of Crataegus oxycantha (AEC) activates mitochondrial protection during isoproterenol - induced myocardial infarction in rats. Mol Cell Biochem. 2006;292(1-2):59–67. doi:10.1007/s11010-006-9218-3.
Ritter M, Melichar K, Strahler S, et al. Cardiac and electrophysiological effects of primary and refined extracts from Leonurus cardiaca L. (Ph.Eur.). Planta Med. 2010;76(6):572–582. doi:10.1055/s-0029-1240602.
Shikov AN, Pozharitskaya ON, Makarov VG, Demchenko DV, Shikh EV. Effect of Leonurus cardiaca oil extract in patients with arterial hypertension accompanied by anxiety and sleep disorders. Phytother Res. 2011;25(4):540–543. doi:10.1002/ptr.3292.
Sun Q, Wang B, Li Y, et al. Taurine Supplementation Lowers Blood Pressure and Improves Vascular Function in Prehypertension: Randomized, Double-Blind, Placebo-Controlled Study. Hypertension. 2016;67(3):541–549. doi:10.1161/HYPERTENSIONAHA.115.06624.
Xie YZ, Zhang XJ, Zhang C, Yang Y, He JN, Chen YX. Protective effects of leonurine against ischemic stroke in mice by activating nuclear factor erythroid 2-related factor 2 pathway. CNS Neurosci Ther. 2019;25(9):1006–1017. doi:10.1111/cns.13146.
Ziyatdinova G, Kozlova E, Morozova E, Budnikov H. Chronocoulometric method for the evaluation of antioxidant capacity of medicinal plant tinctures. Analytical Methods. 2018;10(41):4995–5003. doi:10.1039/C8AY01907J.
Copyright (c) 2020 CHILD`S HEALTH
This work is licensed under a Creative Commons Attribution 4.0 International License.
© Publishing House Zaslavsky, 1997-2020