Functional dyspepsia in children. Problems and prospects of symptomatic therapy

Abstract

The article deals with the problem of functional dyspepsia. Functional dyspepsia is characterized by diverse non-specific symptoms such as discomfort, troublesome early satiety, nausea, or epigastric pain or burning. It can easily be overlooked as the symptoms overlap with gastro-oesophageal reflux disease and irritable bowel syndrome that requires diagnosis specification. The pathophysiology of functional dyspepsia is not completely understood. It is thought to be associated with upper gastrointestinal inflammation and motility disturbances, which may be triggered by an infectious or allergenic agent, or a change in the intestinal microbiome. While functional dyspepsia is distressing and affects the quality of life, it has no long-term impact on mortality. There are many treatment options available, with varying levels of evidence of effectiveness. These include dietary modification, acid suppression, prokinetic drugs including tricyclic antidepressants and psychological therapy. Proton pump inhibitors (PPIs) and prokinetics are commonly used first-line medications. The paper paid attention to a preparation Domrid containing domperidone (prokinetic).