Features of the state of the function of the biliary system in helminth parasitic diseases


  • G.A. Zaslavska Kyiv Medical University, Kyiv, Ukraine




children, helminth parasitic infestations, bile, therapy, Vormil


Pathology of the hepatobiliary tract is widespread throughout the world. When the bile enters the intestine in the inadequate quantity and quality, its peristalsis is disturbed, the walls are irritated, parietal digestion is inadequate and, as a result, ma­l­absorption syndrome and fluid and electrolyte imbalance develop. Helminth parasitic infestations are often the cause of functional disorders. With a prolonged course of functional disorders of the biliary system, conditions are created for the development of organic lesions of the biliary tract, including mechanical occlusion. One of the mechanisms of exposure in helminth parasitic persistence is an increase in the degree of bile lithogenicity as a result of dehydroxylation of bile acids under the influence of microbial enzymes. In this case, chenodeoxycholic acid turns into lithocholic acid, which does not form micelles and, therefore, promotes cholesterol crystallization. Both specific and nonspecific symptoms such as weakness, irritability, mood swings, sleep disorders can indicate damage to the hepatobiliary system of parasitic origin. As a result of the toxic effects of the parasites themselves, products of their decay, drugs aimed at their destruction, the pathology of the hepatobiliary tract develops. In this regard, the comprehensive therapy for helminth parasitic invasions should include drugs that restore the function of the liver and biliary tract. Vormil herbal complex created to eliminate the effects of deworming and to protect against reinfestation, with a unique composition of herbs, has a hepatoprotective, choleretic effect and normalizes gastrointestinal motility. Thus, the use of a combination of Vormil and Vormil Fito herbal complex has an optimal effect in the treatment of helminth parasitic infestations.


Goloshubina VV, Moiseeva MV, Bagisheva NV, Trukhan LIu, Trukhan DI. Functional disorders of the biliary tract: current aspects of diagnosis and treatment. RMJ. Medical Review. 2018;2(3):13-17. (in Russian).

Cotton PB, Elta GH, Carter CR, Pasricha PJ, Corazziari ES. Rome IV. Gallbladder and Sphincter of Oddi Disorders. Gastroenterology. 2016 Feb 19. pii: S0016-5085(16)00224-9. doi: 10.1053/j.gastro.2016.02.033.

Trukhan DI, Filimonov SN. Differentsial'nyi diagnoz osnovnykh gastroenterologicheskikh sindromov i simptomov [Differential diagnosis of the main gastroenterological syndromes and symptoms]. Moscow: Prakticheskaia meditsina; 2016. 168p. (in Russian).

Drossman DA, Hasler WL. Rome IV-Functional GI Disorders: Disorders of Gut-Brain Interaction. Gastroenterology. 2016 May;150(6):1257-61. doi: 10.1053/j.gastro.2016.03.035.

European Association for the Study of the Liver (EASL). EASL Clinical Practice Guidelines on the prevention, diagnosis and treatment of gallstones. J Hepatol. 2016 Jul;65(1):146-181. doi: 10.1016/j.jhep.2016.03.005.

Vinogradova KT. Bolezni biliarnogo trakta [Diseases of the biliary tract]. 3rd ed. Moscow: Medlit; 2015. 264 p. (in Russian).

Maksimov VA, Chernyshov AL, Tarasov KM. Duodenal'noe issledovanie [Duodenal research]. Moscow: Meditsinskaia gazeta; 1998; 192 p. (in Russian).

Miroshnichenko VP, Gaidai VN. Bile acids and cholesterol in bile for diseases of the biliary tract. Likars'ka sprava. 1984;(7):27-29. (in Russian).

Tilichenko IuA, Kapilevich NA, Beloborodova EI, et al. Methods for determining the concentration of total lipids and bile phosphorus. Laboratornoe delo. 1990;(2):8-10. (in Russian).

Thomas PJ, Hofmann AF. Letter: A simple calculation of the lithogenic index of bile: expressing biliary lipid composition on rectangular coordinates. Gastroenterology. 1973 Oct;65(4):698-700.

Rubens IuP, Iurika EV, Seleznev IuV. Indices of lithogenicity of bile: determination methods, clinical availaility, information content. Klinicheskaya meditsina. 1992;70(7-8):39-41. (in Russian).

Bodnia EI. Helminthiasis: a modern view of therapy. Novosti Meditsiny i Farmatsii. 2017;(621):12-15. (in Russian).

Kramariov SO, Zakordonets LV. Helminthiasis in children: treatment approaches. Zdorovʹe rebenka. 2018;13(3):111-118. (in Ukrainian).





Infections in Children