Features of the state of the function of the biliary system in helminth parasitic diseases

Abstract

Pathology of the hepatobiliary tract is widespread throughout the world. When the bile enters the intestine in the inadequate quantity and quality, its peristalsis is disturbed, the walls are irritated, parietal digestion is inadequate and, as a result, ma­l­absorption syndrome and fluid and electrolyte imbalance develop. Helminth parasitic infestations are often the cause of functional disorders. With a prolonged course of functional disorders of the biliary system, conditions are created for the development of organic lesions of the biliary tract, including mechanical occlusion. One of the mechanisms of exposure in helminth parasitic persistence is an increase in the degree of bile lithogenicity as a result of dehydroxylation of bile acids under the influence of microbial enzymes. In this case, chenodeoxycholic acid turns into lithocholic acid, which does not form micelles and, therefore, promotes cholesterol crystallization. Both specific and nonspecific symptoms such as weakness, irritability, mood swings, sleep disorders can indicate damage to the hepatobiliary system of parasitic origin. As a result of the toxic effects of the parasites themselves, products of their decay, drugs aimed at their destruction, the pathology of the hepatobiliary tract develops. In this regard, the comprehensive therapy for helminth parasitic invasions should include drugs that restore the function of the liver and biliary tract. Vormil herbal complex created to eliminate the effects of deworming and to protect against reinfestation, with a unique composition of herbs, has a hepatoprotective, choleretic effect and normalizes gastrointestinal motility. Thus, the use of a combination of Vormil and Vormil Fito herbal complex has an optimal effect in the treatment of helminth parasitic infestations.