DOI: https://doi.org/10.22141/2224-0551.14.4.2019.174043

Modern concepts of vitamin D role in juvenile idiopathic arthritis in children (review)

Y.V. Khadzhynova

Abstract


Arthritis is one of the most common chronic rheumatic diseases in children. Juvenile idiopathic arthritis (JIA) is the current nomenclature that is used to refer to a group of diseases that include chronic arthritis, childhood-onset arthritis of unknown cause. The etiology of JIA is unknown and the pathogenesis is likely to be multifactorial. One of the risk factors for the development of this disease is an insufficient level of vitamin D in the blood serum. The purpose of the analysis of the literature data was to compile and interpret data on the current point of view on the status of vitamin D in children with JIA. This article summarizes reports about the role of vitamin D in the development and clinical manifestation of juvenile arthritis (JA). Plenty of studies show a low level of vitamin D in blood serum in children with juvenile arthritis. At the same time, the role of low vitamin D status in the initiation of juvenile idiopathic arthritis development, activation of the inflammatory process, and further prognosis is controversial. The questions about vitamin D supplementation, its duration and dosage are still relevant. Five biomedical literature search bases were accessed, in the following order: Medline (using Ovid), Embase (using Ovid), Cumulative Index to Nursing and Allied Health Literature (CINHAL), Web of Science, and Scopus.

Keywords


juvenile idiopathic arthritis; juvenile rheumatoid arthritis; juvenile chronic arthritis; vitamin D status; review

References


Abreu-Delgado Y, Isidro RA, Torres EA, et al. Serum vitamin D and colonic vitamin D receptor in inflammatory bowel disease. World J Gastroenterol. 2016 Apr 7;22(13):3581-91. doi: 10.3748/wjg.v22.i13.3581.

Dall’Ara F, Cutolo M, Andreoli L, Tincani A, Paolino S. Vitamin D and systemic lupus erythematous: a review of immunological and clinical aspects. Clin Exp Rheumatol. 2018 Jan-Feb;36(1):153-162.

Haijaj-Hassouni N, Mawani N, Allali F, Rkain H, et al. Evaluation of Vitamin D Status in Rheumatoid Arthritis and Its Association with Disease Activity across 15 Countries: "The COMORA Study". Int J Rheumatol. 2017;2017:5491676. doi: 10.1155/2017/5491676.

Von Scheven E, Burnham JM. Vitamin D supplementation in the pediatric rheumatology clinic. Curr Rheumatol Rep. 2011 Apr;13(2):110-6. doi: 10.1007/s11926-010-0161-7.

Agmon-Levin N, Theodor E, Segal RM, Shoenfeld Y. Vitamin D in systemic and organ-specific autoimmune diseases. Clin Rev Allergy Immunol. 2013 Oct;45(2):256-66. doi: 10.1007/s12016-012-8342-y.

Cutolo M, Pizzorni C, Sulli A. Vitamin D endocrine system involvement in autoimmune rheumatic diseases. Autoimmun Rev. 2011 Dec;11(2):84-7. doi: 10.1016/j.autrev.2011.08.003.

Hewison M. Vitamin D and the immune system: new perspectives on an old theme. Endocrinol Metab Clin North Am. 2010 Jun;39(2):365-79, table of contents. doi: 10.1016/j.ecl.2010.02.010.

Adorini L, Penna G. Control of autoimmune diseases by the vitamin D endocrine system. Nat Clin Pract Rheumatol. 2008 Aug;4(8):404-12. doi: 10.1038/ncprheum0855.

Holick MF. Vitamin D: extraskeletal health. Endocrinol Metab Clin North Am. 2010 Jun;39(2):381-400, table of contents. doi: 10.1016/j.ecl.2010.02.016.

Brewer EJ, Bass J, Baum J, et al. Current proposed revision of JRA criteria. JRA criteria Subcommittee of the Diagnostic and Therapeutic Criteria Committee of the American rheumatism section of the Arthritis Foundation. Arthritis Rheum. 1977 Mar;20(2 Suppl):195-9.

Wood P. Special meeting on nomenclature and classification of arthritis in children In: The care of reumathic children. Basel: EULAR Publishers; 1978. 47-50 pp.

Baeke F, Takiishi T, Korf H, Gysemans C, Mathieu C. Vitamin D: modulator of the immune system. Curr Opin Pharmacol. 2010 Aug;10(4):482-96. doi: 10.1016/j.coph.2010.04.001.

Borchers AT, Selmi C, Cheema G, Keen CL, Shoenfeld Y, Gershwin ME. Juvenile idiopathic arthritis. Autoimmun Rev. 2006 Apr;5(4):279-98. doi: 10.1016/j.autrev.2005.09.011.

Institute of Medicine (US) Committee to Review Dietary Reference Intakes for Vitamin D and Calcium; Ross AC, Taylor CL, Yaktine AL, Del Valle HB, editors. Dietary Reference Intakes for Calcium and Vitamin D. Washington: National Academies Press; 2011. doi: 10.17226/13050.

Holick MF, Binkley NC, Bischoff-Ferrari HA, et al. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2011 Jul;96(7):1911-30. doi: 10.1210/jc.2011-0385.

Dağdeviren-çakır A, Arvas A, Barut K, Gür E, Kasapçopur Ö. Serum vitamin D levels during activation and remission periods of patients with juvenile idiopathic arthritis and familial Mediterranean fever. Turk J Pediatr. 2016;58(2):125-131. doi: 10.24953/turkjped.2016.02.001.

De Sousa Studart SA, Leite AC, Marinho AL, et al. Vitamin D levels in juvenile idiopathic arthritis from an equatorial region. Rheumatol Int. 2015 Oct;35(10):1717-23. doi: 10.1007/s00296-015-3287-0.

Stagi S, Bertini F, Cavalli L, Matucci-cerinic M, Brandi ML, Falcini F. Determinants of vitamin D levels in children, adolescents, and young adults with juvenile idiopathic arthritis determinants of vitamin D levels in children, adolescents, and young adults with juvenile idiopathic arthritis. J Rheumatol. 2014 Sep;41(9):1884-92. doi: 10.3899/jrheum.131421.

Szymańska-Kałuża J. Biernacka-ZielińskaM, Stańczyk J, Smolewska E. Vitamin D level in children with juvenile idiopathic arthritis and its correlation with clinical picture of the disease. Reumatologia. 2013;(51):271-6. doi: 10.5114/reum.2013.37250.

Munekata RV, Terreri MTRA, Peracchi OAB, Len C. Serum 25-hydroxyvitamin D and biochemical markers of bone metabolism in patients with juvenile idiopathic arthritis. Braz J Med Biol Res. 2013 Jan;46(1):98-102. doi: 10.1590/1414-431X20122477.

Lien G, Selvaag AM, Flatø B, et al. A two-year prospective controlled study of bone mass and bone turnover in children with early juvenile idiopathic arthritis. Arthritis Rheum. 2005 Mar;52(3):833-40. doi: 10.1002/art.20963.

Tang X, Mingyue L. Association between vitamin D concentrations with disease activity and bone mineral density of juvenile idiopathic arthritis patients. In: Abstracts of the 18th Asia Pacific League of Associations for Rheumatology Congress (APLAR), 26-29 September 2016, Shanghai, China. Int J Rheum Dis. 2016 Sep;19 Suppl 2:3-293. doi: 10.1111/1756-185X.12961.

Alhomaidah D, Alsagheir A, Al-Mayouf SM. Coexistence of endocrinopathies in children with rheumatic diseases. Int J Pediatr Adolesc Med. 2016;3:119-122. doi: 10.1016/j.ijpam.2016.04.002.

Goralczyk A, Konstantynowicz J, Abramowicz P, Dobrenko E, Babinska-Malec E. Deficits of vitamin D are strongly associated with methotrexate treatment in patients with juvenile idiopathic arthritis. In: International conference on childrens bone health. 2015, June 27-30; Salzburg, Austria. Salzburg; 2015. 113 p.

Peixoto D, Teixeira F, Lucas R, Costa J, Costa L. Vitamin D status in patients with juvenile idiopathic arthritis. Ann Rheum Dis. 2014;71(Suppl 3):702.

Dey S, Jahan A, Yadav TP, Bhagwani DK, Sachdev N. Measurement of bone mineral density by dual energy X-ray absorptiometry in juvenile idiopathic arthritis. Indian J Pediatr. 2014 Feb;81(2):126-32. doi: 10.1007/s12098-013-1037-4.

Çomak E, Doğan ÇS, Uslu-gökçeoğlu A, et al. Association between vitamin D deficiency and disease activity in juvenile idiopathic arthritis. Turk J Pediatr. 2014 Nov-Dec;56(6):626-31.

Bouaddi I, Rostom S, El Badri D, et al. Vitamin D concentrations and disease activity in Moroccan children with juvenile idiopathic arthritis. BMC Musculoskelet Disord. 2014 Apr 1;15:115. doi: 10.1186/1471-2474-15-115.

Miettinen ME, Kinnunen L, Harjutsalo V, et al. Serum 25-hydroxyvitamin D in juvenile idiopathic arthritis patients in Finland-letters to the editors. Clin Exp Rheumatol. 2013 Nov-Dec;31(6):988.

Nisar M, Cookson P, Masood F, Sansome A, Ostor A. AB0693 Is there a link between vitamin d and juvenile idiopathic arthritis? Ann Rheum Dis. 2013;(72):A999-A1000. doi: 10.1136/annrheumdis-2013-eular.3015L.

Pelajo CF, Lopez-Benitez JM, Kent DM, Price LL, Miller LC, Dawson-Hughes B. 25-hydroxyvitamin D levels and juvenile idiopathic arthritis: is there an association with disease activity? Rheumatol Int. 2012 Dec;32(12):3923-9. doi: 10.1007/s00296-011-2287-y.

Markula-patjas KP, Valta HL, Kerttula LI, et al. Prevalence of vertebral compression fractures and associated factors in children and adolescents with severe juvenile idiopathic arthritis. J Rheumatol. 2012 Feb;39(2):365-73. doi: 10.3899/jrheum.110305.

Valta H, Lahdenne P, Jalanko H, Aalto K. Bone health and growth in glucocorticoid-treated patients with juvenile idiopathic arthritis. J Rheumatol. 2007 Apr;34(4):831-6.

Rosiles VH, Salazar CD, Velazquez RM, Ruiz RR. Determination of 25(OH)D serum levels in children with systemic lupus erythematosus and juvenile idiopathic arthritis. Bol Med Hosp Infant Mex. 2015 Mar - Apr;72(2):99-105. doi: 10.1016/j.bmhimx. (in Spanish).

Siamopoulou A, Challa A, Kapoglou P, Cholevas V, Mavridis AK, Lapatsanis PD. Effects of intranasal salmon calcitonin in juvenile idiopathic arthritis: an observational study. Calcif Tissue Int. 2001 Jul;69(1):25-30. doi: 10.1007/s00223-001-0008-3.

Bianchi ML, Bardare M, Caraceni MP, et al. Bone metabolism in juvenile rheumatoid arthritis. Bone Miner. 1990 May;9(2):153-62. doi: 10.1016/0169-6009(90)90081-P.

Reed AM, Haugen M, Pachman LM, Langman CB. Repair of osteopenia in children with juvenile rheumatoid arthritis. J Pediatr. 1993 May;122(5 Pt 1):693-6. doi: 10.1016/S0022-3476(06)80006-5.

Pepmueller PH, Cassidy JT, Allen SH, Hillman LS. Bone mineralization and bone mineral metabolism in children with juvenile rheumatoid arthritis. Arthritis Rheum. 1996 May;39(5):746-57. doi: 10.1002/art.1780390506.

Henderson CJ, Cawkwell GD, Specker BL, Sierra RI, Wilmott RW, Campaigne BN. Non-corticosteroid-treated prepubertal children with juvenile rheumatoid arthritis. Arthritis Rheum. 1997;(40)11:1967-1975. doi: 10.1002/art.1780401108.

Stark LJ, Davis AM, Janicke DM, et al. A randomized clinical trial of dietary calcium to improve bone accretion in children with juvenile rheumatiod arthritis. J Pediatr. 2006 Apr;148(4):501-7. doi: 10.1016/j.jpeds.2005.11.043.

Reed A, Haugen M, Pachman LM, Langman CB. 25-Hydroxyvitamin D therapy in children with active juvenile rheumatoid arthritis: short-term effects on serum osteocalcin levels and bone mineral density. J Pediatr. 1991 Oct;119(4):657-60. doi: 10.1016/S0022-3476(05)82424-2.

Hillman L, Cassidy JT, Johnson L, Lee D, Allen SH. Vitamin D metabolism and bone mineralization in children with juvenile rheumatoid arthritis. J Pediatr. 1994 Jun;124(6):910-6. doi: 10.1016/S0022-3476(05)83179-8.

Falcini F, Ermini M, Bagnoli F. Bone turnover is reduced in children with juvenile rheumatoid arthritis. J Endocrinol Invest. 1998 Jan;21(1):31-6. doi: 10.1007/BF03347283.

Rooney M, Davies UM, Reeve J, Preece M, Ansell BM, Woo PM. Bone mineral content and bone mineral metabolism: changes after growth hormone treatment in juvenile chronic arthritis. J Rheumatol. 2000 Apr;27(4):1073-81.

Tzoufi M, Siamopoulou-Mavridou A, Challa A, Lapatsanis PD. Changes of mineral metabolism in juvenile chronic arthritis. Acta Paediatr Suppl. 1994 Mar;394:52-7. doi: 10.1111/j.1651-2227.1994.tb13215.x.

Elsasser U, Wilkins B, Hesp R, Thurnham DI, Reeve J, Ansell BM. Bone rarefaction and crush fractures in juvenile chronic arthritis. Arch Dis Child. 1982 May;57(5):377-80. doi: 10.1136/adc.57.5.377.

Johansson U, Portinsson S, Akesson A, Svantesson H, Ockerman PA, Akesson B. Nutritional status in girls with juvenile arthritis. Hum Nutr Clin Nutr. 1986 Jan;40(1):57-67.

Reeve J, Loftus J, Hesp R, Ansell BM, Wright DJ, Woo PMM. Biochemical prediction of changes in spinal bone mass in juvenile chronic (or rheumatoid) arthritis treated with glucocorticoids. J Rheumatol. 1993 Jul;20(7):1189-95.

Hillman LS, Cassidy JT, Chanetsa F, Hewett JE, Higgins BJ, Robertson JD. Percent true calcium absorption, mineral metabolism, and bone mass in children with arthritis: effect of supplementation with vitamin D3 and calcium. Arthritis Rheum. 2008 Oct;58(10):3255-63. doi: 10.1002/art.23809.

Warady BD, Lindsley CB, Robinson FG, Lukert BP. Effects of nutritional supplementation on bone mineral status of children with rheumatic diseases receiving corticosteroid therapy. J Rheumatol. 1994 Mar;21(3):530-5.

McNally JD, Menon K, Chakraborty P, et al. The association of vitamin D status with pediatric critical illness. Pediatrics. 2012 Sep;130(3):429-36. doi: 10.1542/peds.2011-3059.

Reed A, Haugen M, Pachman LM, Langman CB. Abnormalities in serum osteocalcin values in children with chronic rheumatic diseases. J Pediatr. 1990 Apr;116(4):574-80. doi: 10.1016/S0022-3476(05)81605-1.

Cutolo M, Otsa K, Uprus M, Paolino S, Seriolo B. Vitamin D in rheumatoid arthritis. Autoimmun Rev. 2007 Nov;7(1):59-64. doi: 10.1016/j.autrev.2007.07.001.

Ringold S, Wallace CA. Measuring clinical response and remission in juvenile idiopathic arthritis. Curr Opin Rheumatol. 2007 Sep;19(5):471-6. doi: 10.1097/BOR.0b013e32825a6a68.

Ringold S, Weiss PF, Beukelman T, et al. 2013 update of the 2011 American College of Rheumatology recommendations for the treatment of juvenile idiopathic arthritis: recommendations for the medical therapy of children with systemic juvenile idiopathic arthritis and tuberculosis screening among children receiving biologic medications. Arthritis Care Res (Hoboken). 2013 Oct;65(10):1551-63. doi: 10.1002/acr.22087.

Dankers W, Colin EM, van Hamburg JP, Lubberts E. Vitamin D in autoimmunity: molecular mechanisms and therapeutic potential. Front Immunol. 2017 Jan 20;7:697. doi: 10.3389/fimmu.2016.00697.

McNally JD, Matheson LA, Rosenberg AM. Epidemiologic considerations in unexplained pediatric arthralgia: the role of season, school, and stress. J Rheumatol. 2009 Feb;36(2):427-33. doi: 10.3899/jrheum.080358.

Wang Y, Lu MP, Teng LP, et al. Association of vitamin D concentrations with juvenile idiopathic arthritis. Zhongguo Dang Dai Er Ke Za Zhi. 2015 Apr;17(4):375-8.

Kvasnnina LV. Immunomodulatory properties of vitamin D in children. Zdorovʹe rebenka. 2013;(50):134-138. doi: 10.22141/2224-0551.7.50.2013.84919. (in Russian).

Kvasnnina LV. Vitamin D in different periods of childhood: what we know, what we need to remember and what we have forgotten. Zdorov’ja Ukrai'ny. Pediatrija. 2017;(43):29-31. (in Russian).






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