DOI: https://doi.org/10.22141/2224-0551.14.4.2019.174032

Neurotransmitter serum levels in children with recurrent upper respiratory tract infections

L.S. Ovcharenko, D.M. Sheludko, A.O. Vertehel, I.V. Samokhin, T.G. Andrienko, A.V. Kryazhev

Abstract


Background. Schoolchildren are prone to frequent respiratory tract diseases. In the structure of general morbidity, this pathology ranks first. Its prevalence is more than 60 %, which leads to frequent school absenteeism, lack of active games and outdoor walks. So, there is an increase in the amount of time that a child spent on means of mass electronic communication and electronic games, resulting in high affection and addiction, forming hypodynamia, which in aggregate has a negative impact on the regulatory systems functioning. Recurrent upper respiratory tract infections (URTI) contribute to the strain of neuro-endocrine-immune regulation, causing an imbalance of neuropeptides — mediators of neurogenic inflammation. The purpose of this work is to study the neurogenic inflammation parameters in schoolchildren with functional disorders of the cardiovascular system and recurrent respiratory tract diseases. Materials and methods. We surveyed 130 children with URTI aged 6 to 9 years in the somatic well-being period. The analysis of the contents of vasoactive intestinal peptide (VIP), substance P and final stable metabolites of nitric oxide (FSM NO) in serum was carried out. An increase in substance P level in children with recurrent URTI was found, which had statistically significant differences with the healthy children indices (p < 0.05). Results. It has been found that high concentration of substance P increases the risk of recurrent URTI. It has been proved that in children with recurrent URTI due to increased FSM NO serum content that has a pro-inflammatory orientation, there is an increased neurogenic inflammation activity. It was found that the reliable reduction in the content of VIP as an anti-inflammatory transmitter in children with recurrent URTI can not suppress the activity of neurogenic inflammation, resulting in its excessive stimulation. Conclusions. Children with recurrent URTI in the somatic well-being period have increased serum levels of substance Р and FSM NO. In the somatic well-being period in schoolchildren with recurrent URTI, a decrease in the concentration of anti-inflammatory neuropeptide VIP is observed.


Keywords


children; neuropeptides; substance Р; recurrent upper respiratory tract infections

Full Text:

PDF

References


Grigoryeva VA, Melnikova IM, Mizernitsky YuL. Current views on the role of neuroimmune components in the pathogenesis of respiratory diseases. Rossiyskiy Vestnik Perinatologii i Pediatrii. 2011;56(4):36-40. (in Russian).

Kazyukova TV, Koval GS, Samsygina GA, et al. Often ill children: modern possibilities of reducing respiratory morbidity. Pediatria. 2012;91(5):42-48. (in Russian).

Mukvіch OM, Omelchenko LІ. Prevention of recurrent acute respiratory infections in school-age children. Dytiachyi likar. 2013;(27):65-70.

Ovcharenko LS, Shamray IV, Vertegel AA. Neuroimmune mechanisms genesis of recurrent bronchitis in children. Perinatologiya i pediatriya. 2013;(3):118-125.

Ovcharenko LS, Voloshin MA, Vertegel AA, et al. Neuroimmunocorrection in children with recurrent bronchitis and perinatal disturbances of the central nervous system: Methodical recommendations. Kyiv; 2015. 19 p.

Rechkina E. A. Often ill children and the role of immunocorrection in their treatment. Astma ta alergіa. 2013;(1):44-47.

Urjas'ev OM, Shakhanov AV. Role of nitric oxide synthases polymorphism in the development of comorbidity of bronchial asthma and hypertension. Kazan medical journal. 2017;98(2):226-232.

Ministry of Health of Ukraine. Annual report on the health status of the population, the sanitary and epidemiological situation and the results of the Ukrainian health care system in 2015. Kyiv; 2016. 452 p.

Ang SF, Moochhala SM, MacAry PA, Bhatia M. Hydrogen sulfide and neurogenic inflammation in polymicrobial sepsis: involvement of substance P and ERK-NF-κB signaling. PLoS One. 2011;6(9):e24535. doi: 10.1371/journal.pone.0024535.

Chandrasekharan B, Nezami BG, Srinivasan S. Emerging neuropeptide targets in inflammation: NPY and VIP. Am J Physiol Gastrointest Liver Physiol. 2013 Jun 1;304(11):G949-57. doi: 10.1152/ajpgi.00493.2012.

Ganea D, Hooper KM, Kong W. The neuropeptide vasoactive intestinal peptide: direct effects on immune cells and involvement in inflammatory and autoimmune diseases. Acta physiologica (Oxford, England). 2015;213(2):442-452. doi:10.1111/apha.12427.

Malhotra R. Understanding migraine: Potential role of neurogenic inflammation. Ann Indian Acad Neurol. 2016 Apr-Jun;19(2):175-82. doi: 10.4103/0972-2327.182302.

Souza-Moreira L, Campos-Salinas J, Caro M, Gonzalez-Rey E. Neuropeptides as pleiotropic modulators of the immune response. Neuroendocrinology. 2011;94(2):89-100. doi: 10.1159/000328636.

Waschek JA. VIP and PACAP: neuropeptide modulators of CNS inflammation, injury, and repair. Br J Pharmacol. 2013 Jun;169(3):512-23. doi: 10.1111/bph.12181.






Copyright (c) 2019 CHILD`S HEALTH

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

 

© Publishing House Zaslavsky, 1997-2019

 

   Seo анализ сайта