DOI: https://doi.org/10.22141/2224-0551.14.3.2019.168803

Drugs inhibiting the quorum-sensing of bacteria Staphylococcus aureus

А.Е. Abaturov, Т.А. Kryuchko

Abstract


The scientific review presents data on the functioning of the quorum-sensing systems Agr and RAP/TRAP of Staphylococcus aureus bacteria. The paper gives the characteristics of medications inhibiting the export of AIP from a bacterial cell, the activity of histidine kinase AgrC, the expression and functional activity of AgrA, the expression of the RNAIII transcript of Staphylococcus aureus bacteria. It is suggested that the drugs developed to inhibit the activity of the mechanisms of the quorum sensing of Staphylococcus aureus bacteria will take a worthy place in anti-staphylococcal therapy.

Keywords


quorum sensing; Staphylococcus aureus; inhibitors of quorum sensing; review

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