Quorum sensing inhibitors of bacteria Streptococcus pneumoniae

А.Е. Abaturov, Т.А. Kryuchko


The scientific review systematizes information on LuxS/AI-2 and ComABCDE quorum sensing systems of bacteria Streptococcus pneumoniae. It is emphasized that biofilms of bacteria Streptococcus pneumoniae are one of the mechanisms of antibiotic resistance and a source of highly invasive bacterial clones. A brief description of 5-azacytidine, sinefungin and pyrimidinedione, which have a specific anti-biofilm effect, is given.


quorum sensing; Streptococcus pneumoniae; quorum sensing inhibitors


Abaturov AE, Bolbot YuK, Alifanova SV, et al. [Pneumococcal infection in children (monograph)]. Khmelnitsky: FLPstorozhuk; 2016. 200 p. (in Russian).

Abaturov AE, Volosovets AP, Yulish EI. The role of Toll-like receptors in the reacciation of pathogen-associated molecular structures of infectious pathogenic agents in the development of inflammation, Part 1: Family TLR. Zdorov`e rebenka. 2012;(40):116-121. (in Russian).

Abaturov AE, Nikulina AA, Petrenko LL. [The development of the immune response in pneumococcal pneumonia (part 1)]. Sovremennaya pediatriya. 2016;4(76):47-56. doi: 10.15574/SP.2016.76.47. (in Russian).

Mayanskiy AN, Chebotar IV, Lazareva AV, Mayanskiy NA. Biofilm formation by Streptococcus pneumonia. Molecular Genetics, Microbiology and Virology. 2015;30(3):124-131.

Chao Y, Marks LR, Pettigrew MM, Hakansson AP. Streptococcus pneumoniae biofilm formation and dispersion during colonization and disease. Front Cell Infect Microbiol. 2015 Jan 13;4:194. doi: 10.3389/fcimb.2014.00194.

Chao Y, Bergenfelz C, Håkansson AP. In Vitro and In Vivo Biofilm Formation by Pathogenic Streptococci. Methods Mol Biol. 2017;1535:285-299. doi: 10.1007/978-1-4939-6673-8_19.

Cvitkovitch DG, Li YH, Ellen RP. Quorum sensing and biofilm formation in Streptococcal infections. J Clin Invest. 2003 Dec;112(11):1626-32. doi: 10.1172/JCI20430.

Domenech M, García E, Moscoso M. Biofilm formation in Streptococcus pneumoniae. Microb Biotechnol. 2012 Jul;5(4):455-65. doi: 10.1111/j.1751-7915.2011.00294.x.

Galante J, Ho AC, Tingey S, Charalambous BM. Quorum sensing and biofilms in the pathogen, Streptococcus pneumoniae. Curr Pharm Des. 2015;21(1):25-30.doi: 10.2174/1381612820666140905113336.

Hakansson AP, Orihuela CJ, Bogaert D. Bacterial-Host Interactions: Physiology and Pathophysiology of Respiratory Infection. Physiol Rev. 2018 Apr 1;98(2):781-811. doi: 10.1152/physrev.00040.2016.

Hercik K, Brynda J, Nencka R, Boura E. Structural basis of Zika virus methyltransferase inhibition by sinefungin. Arch Virol. 2017 Jul;162(7):2091-2096. doi: 10.1007/s00705-017-3345-x.

Koliou MG, Andreou K, Lamnisos D, et al Risk factors for carriage of Streptococcus pneumoniae in children. BMC Pediatr. 2018 Apr 26;18(1):144. doi: 10.1186/s12887-018-1119-6.

Laurenceau R, Krasteva PV, Diallo A, et al. Conserved Streptococcus pneumoniae spirosomes suggest a single type of transformation pilus in competence. PLoS Pathog. 2015 Apr 15;11(4):e1004835. doi: 10.1371/journal.ppat.1004835.

Marrie TJ, Tyrrell GJ, Majumdar SR, et al. Invasive Pneumococcal Disease: Still Lots to Learn and a Need for Standardized Data Collection Instruments. Can Respir J. 2017;2017:2397429. doi: 10.1155/2017/2397429.

McCarthy MW, Walsh TJ. Amino Acid Metabolism and Transport Mechanisms as Potential Antifungal Targets. Int J Mol Sci. 2018 Mar 19;19(3). pii: E909. doi: 10.3390/ijms19030909.

Morrill HJ, Caffrey AR, Noh E, LaPlante KL. Epidemiology of pneumococcal disease in a national cohort of older adults. Infect Dis Ther. 2014 Jun;3(1):19-33. doi: 10.1007/s40121-014-0025-y.

Nelson KN, Grijalva CG, Chochua S, et al. Dynamics of Colonization of Streptococcus pneumoniae Strains in Healthy Peruvian Children. Open Forum Infect Dis. 2018 Feb 17;5(3):ofy039. doi: 10.1093/ofid/ofy039.

Parveen N, Cornell KA. Methylthioadenosine/S-adenosylhomocysteine nucleosidase, a critical enzyme for bacterial metabolism. Mol Microbiol. 2011 Jan;79(1):7-20. doi: 10.1111/j.1365-2958.2010.07455.x.

Shanker E, Federle MJ. Quorum Sensing Regulation of Competence and Bacteriocins in Streptococcus pneumoniae and mutans. Genes (Basel). 2017 Jan 5;8(1). pii: E15. doi: 10.3390/genes8010015.

Silva-Costa C, Brito MJ, Pinho MD, et al. Pediatric Complicated Pneumonia Caused by Streptococcus pneumoniae Serotype 3 in 13-Valent Pneumococcal Conjugate Vaccinees, Portugal, 2010-2015. Emerg Infect Dis. 2018 Jul;24(7):1307-1314. doi: 10.3201/eid2407.180029.

Trappetti C, McAllister LJ, Chen A, et al. Autoinducer 2 Signaling via the Phosphotransferase FruA Drives Galactose Utilization by Streptococcus pneumoniae, Resulting in Hypervirulence. MBio. 2017 Jan 24;8(1). pii: e02269-16. doi: 10.1128/mBio.02269-16.

Trappetti C, Potter AJ, Paton AW, et al. LuxS mediates iron-dependent biofilm formation, competence, and fratricide in Streptococcus pneumonia. Infect Immun. 2011 Nov;79(11):4550-8. doi: 10.1128/IAI.05644-11.

Wang Y, Sun L, et al. The LuxS/AI-2 system of Streptococcus suis. Appl Microbiol Biotechnol. 2018 Sep;102(17):7231-7238. doi: 10.1007/s00253-018-9170-7.

Yadav MK, Park SW, Chae SW, Song JJ. Sinefungin, a natural nucleoside analogue of S-adenosylmethionine, inhibits Streptococcus pneumoniae biofilm growth. Biomed Res Int. 2014;2014:156987. doi: 10.1155/2014/156987.

Yadav MK, Vidal JE, Go YY, et al. The LuxS/AI-2 Quorum-Sensing System of Streptococcus pneumoniae Is Required to Cause Disease, and to Regulate Virulence- and Metabolism-Related Genes in a Rat Model of Middle Ear Infection. Front Cell Infect Microbiol. 2018 May 4;8:138. doi: 10.3389/fcimb.2018.00138.

Yadav MK, Go YY, Chae SW, Song JJ. The Small Molecule DAM Inhibitor, Pyrimidinedione, Disrupts Streptococcus pneumoniae Biofilm Growth In Vitro. PLoS One. 2015 Oct 2;10(10):e0139238. doi: 10.1371/journal.pone.0139238.

Yadav MK, Chae SW, Song JJ. Effect of 5-azacytidine on in vitro biofilm formation of Streptococcus pneumonia. Microb Pathog. 2012 Nov-Dec;53(5-6):219-26. doi: 10.1016/j.micpath.2012.08.003.

Yang Y, Koirala B, Sanchez LA, et al. Structure-Activity Relationships of the Competence Stimulating Peptides (CSPs) in Streptococcus pneumoniae Reveal Motifs Critical for Intra-group and Cross-group ComD Receptor Activation. ACS Chem Biol. 2017 Apr 21;12(4):1141-1151. doi: 10.1021/acschembio.7b00007.

Copyright (c) 2020 CHILD`S HEALTH

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.


© Publishing House Zaslavsky, 1997-2020


   Seo анализ сайта