Gastric emptying in children with diffuse nontoxic goiter

T.V. Sorokman, M.I. Bachu


Background. It has been proved that pupils with thyroid diseases, in particular diffuse nontoxic goiter (DNG), suffer from digestive disorders almost 2.5 times more often. The purpose was to study the features of gastric emptying in children with diffuse nontoxic goiter. Materials and methods. The main group included children with DNG (n = 89), the comparison group — children without thyroid diseases (n = 84). A multi-faceted questionnaire survey, thyroid ultrasonography and functional ultrasonography of the stomach were conducted. Results. The prevalence of goiter among children of Bukovina was 53.3 %. The frequency of functional gastrointestinal disorders in children of both groups was 27.55 ± 2.17 %: in patients with DNG — 33.9 ± 2.3 %, in children without DNG — 21.4 ± 1.3 %, p < 0.05. Impaired gastric emptying was detected in 12 patients with DNG (11.6 %) and in 6 (8.5 %) children without DNG. Most often, these violations were registered in patients with functional dyspepsia. Conclusions. A significantly higher frequency of functional gastrointestinal disorders in children with diffuse nontoxic goiter, including impaired gastric emptying, was established. Treatment of somatic disease will reduce the frequency of unfavorable course of DNG in children and adolescents.


diffuse nontoxic goiter; gastric emptying; children


Heinsch ML, Nightingale S. Functional gastrointestinal disorders in children and adolescents: Knowledge, practice and attitudes of Australian paediatricians. J Paediatr Child Health. 2019 Jan 9. doi: 10.1111/jpc.14342.

Rodionova ON, Trubina NV, Reutova EYu, Vidiker RV, Babaeva АR. Peculiarities of neurohumoral regulation disfunction, cytokin and thyroid status in patients with functional gastrointestinal disorders. Vestnik Sankt-Peterburgskogo universiteta. Medicina. 2009;(1): 51-56. (in Russian).

Malik R, Hodgson H. The relationship between the thyroid gland and the liver. QJM. 2002 Sep;95(9):559-69. doi: 10.1093/qjmed/95.9.559.

Chiou E, Nurko S. Functional abdominal pain and irritable bowel syndrome in children and adolescents. Therapy. 2011 May 1;8(3):315-331.

Drossman DA. Functional gastrointestinal disorders: history, pathophysiology, clinical features and Rome IV. Gastroenterology. 2016 Feb 19. pii: S0016-5085(16)00223-7. doi: 10.1053/j.gastro.2016.02.032. 

Drossman DA, Tack J, Ford AC, Szigethy E, Törnblom H, Van Oudenhove L. Neuromodulators for Functional Gastrointestinal Disorders (Disorders of Gut-Brain Interaction): A Rome Foundation Working Team Report. Gastroenterology. 2018 Mar;154(4):1140-1171.e1. doi: 10.1053/j.gastro.2017.11.279.

Zelins'ka NB, Reznikova AL, Mamenko MJe, Jerohina OI. Goiter in children: clinic, differential diagnosis, treatment: guidelines. Sovremennaya pediatriya. 2006;(10):57-66. (in Ukrainian).

Buriak VN, Murashko ES. Peculiarities of thyroid pathology in the childhood. Lik Sprava. 2012 Jul-Sep; (5):58-63. (in Russian).

Plekhova EI, Kashkalda DA, Volkova IuV, Turchina SI, Kosovtsova AV, Kostenko TP. Imbalance of microelements and vitamins in adolescents with diffuse nontoxic goiter and biliary dyskinesia. Lik Sprava. 2014 Nov;(11):138-42. (in Russian).

Ministry of Нealth of Ukraine. Order on April 27, 2006 № 254. On Adoption of the Protocols for the Provision of Medical Aid to Children in Pediatric Endocrinology. Available from: Accessed: April 27, 2006. (in Ukrainian).

Drossman DA. The functional gastrointestinal disorders and the Rome III process. Gastroenterology. 2006 Apr;130(5):1377-90. doi: 10.1053/j.gastro.2006.03.008.

Ministry of Нealth of Ukraine. Order on January 29, 2013 № 59. On Adoption of Standardized Clinical Protocols of Medical Care for Children with Diseases of the Digestive Organs. Available from: Accessed: January 29, 2013. (in Ukrainian).

Bolondi L, Bortolotti M, Santi V, Calletti T, Gaiani S, Labo G. Measurement of gastric emptying time by realмtime ultrasonograph. Gastroenterology. 1985 Oct;89(4):752-9.

Fahmy ME, Osman MA, Mahmoud RA, Mohamed LK, Seif-elnasr KI, Eskander AE. Measuring of Gastric Emtying in Egyptian Pediatric Patients with Porм tal Hypertention by Using Realмtime Ultrasound. Saudi J Gastroenterol. 2012 Jan-Feb;18(1):40-3. doi: 10.4103/1319-3767.91739.

Copyright (c) 2019 CHILD`S HEALTH

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.


© Publishing House Zaslavsky, 1997-2019


   Seo анализ сайта