Systemic circulation in children with diet-related diseases

Yu.N. Nechytailo, T.N. Mikhiеieva, O.Ya. Pidmurniak, N.I. Kovtyuk


Background. The basic group of diet-related diseases is gastroenterological pathology, obesity, metabolic syndrome and diabetes mellitus. One of the leading mechanisms in the course of these pathologies is an imbalance in the autonomic system, which is accompanied by disorders of the systemic circulation, including blood pressure regulation. The purpose of the study was to analyze the characteristics of nutrition and to assess the blood pressure in children with diet-related diseases. Materials and methods. One-hundred and two school-age children who were hospitalized in various departments for chronic gastroduodenitis (the first group — 90 children) and endocrine pathology — the hypothalamic obesity syndrome (the second group — 21 children) and diabetes (the third group — 31 children) were examined. Features of the regime and quality of food were studied on a specially designed questionnaire. The status of systemic circulation was determined using an office measurement of blood pressure and daily blood pressure monito­ring. The results of the children examination were processed ­using Statistics 6.0. Results. Analysis of the nutrition of children has revealed a significant imbalance and a significant difference in a frequency of food consumption among schoolchildren. Having evaluated the level of blood pressure in children according to the reciprocal tables, a significantly larger number of detected pre-hypertension and hypertension cases in individuals in the 2nd and 3rd groups are observed compared with the 1st group. These children have variability in daily blood pressure monitoring, which may be associated with an imbalance of the autonomic nervous system. Conclusions. Imbalanced nutrition contributes to the development of such diet-related diseases. Changes in the systemic circulation in the examined children are associated with the peculiarities of the autonomic regulation of the endocrine and digestive systems, which indicates the combined pathogenetic mechanisms of the development of the pathology of both systems.


children; arterial hypertension; chronic gastroduodenitis; diabetes mellitus; obesity


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