Inhibition of bacterial quorum sensing (general concept)

А.Е. Abaturov, Т.А. Kryuchko


The scientific review outlines current data characteri­zing the main provisions on the functioning of the mechanism of the sensory quorum in the system of interbacterial communications. A general characteristic of various compounds possessing an overwhelming influence on quorum sensory is presented. It is emphasized that the mechanism of sensory quorum inhibition is represented by three functional groups: a group of substances that suppress the activity of autoinducer synthases; a group of substances that block the autoinducer receptors; a group of substances that interfere with autoinducers interaction with their specific receptor.


quorum sensing; quorum sensing inhibitors; review


Abaturov AE, Volosovets AP, Yulish YeI. Role of toll-like receptors in recognition of pathogen-associated molecular structures of infectious pathogen agents and development of inflammation. Part 1. The family of TLR. Zdorov`e rebenka. 2012;(40):116-121.

Abisado RG, Benomar S, Klaus JR, Dandekar AA, Chandler JR. Bacterial Quorum Sensing and Microbial Community Interactions. MBio. 2018 May 22;9(3). pii: e02331-17. doi: 10.1128/mBio.02331-17.

Banerjee G, Ray AK. Quorum-sensing network-associated gene regulation in Gram-positive bacteria. Acta Microbiol Immunol Hung. 2017 Dec 1;64(4):439-453. doi: 10.1556/030.64.2017.040.

Brango-Vanegas J, Costa GM, Ortmann CF, et al. Glycosylflavonoids from Cecropia pachystachya Trécul are quorum sensing inhibitors. Phytomedicine. 2014 Apr 15;21(5):670-5. doi: 10.1016/j.phymed.2014.01.001.

Castillo-Juárez I, Maeda T, Mandujano-Tinoco EA, et al. Role of quorum sensing in bacterial infections. World J Clin Cases. 2015 Jul 16;3(7):575-98. doi: 10.12998/wjcc.v3.i7.575.

Chen F, Gao Y, Chen X, Yu Z, Li X. Quorum quenching enzymes and their application in degrading signal molecules to block quorum sensing-dependent infection. Int J Mol Sci. 2013 Aug 26;14(9):17477-500. doi: 10.3390/ijms140917477.

Cirkovic I, Pavlovic B, Bozic DD, Jotic A, Bakic L, Milovanovic J. Antibiofilm effects of topical corticosteroids and intranasal saline in patients with chronic rhinosinusitis with nasal polyps depend on bacterial species and their biofilm-forming capacity. Eur Arch Otorhinolaryngol. 2017 Apr;274(4):1897-1903. doi: 10.1007/s00405-017-4454-6.

de Nys R, Givskov M, Kumar N, Kjelleberg S, Steinberg PD. Furanones. Prog Mol Subcell Biol. 2006;42:55-86.

Defoirdt T. Quorum-Sensing Systems as Targets for Antivirulence Therapy. Trends Microbiol. 2018 Apr;26(4):313-328. doi: 10.1016/j.tim.2017.10.005.

Du Y, Li T, Wan Y, Long Q, Liao P. Signal molecule-dependent quorum-sensing and quorum-quenching enzymes in bacteria. Crit Rev Eukaryot Gene Expr. 2014;24(2):117-32.

Galkin M, Ivanitsia V, Ishkov Y, Galkin B, Filipova T. Characteristics of the Pseudomonas aeruginosa PA01 Intercellular Signaling Pathway (Quorum Sensing) Functioning in Presence of Porphyrins Bismuth Complexes. Pol J Microbiol. 2015;64(2):101-6.

Giaouris E, Heir E, Desvaux M, et al. Intra- and inter-species interactions within biofilms of important foodborne bacterial pathogens. Front Microbiol. 2015 Aug 20;6:841. doi: 10.3389/fmicb.2015.00841.

Hurley A, Bassler BL. Asymmetric regulation of quorum-sensing receptors drives autoinducer-specific gene expression programs in Vibrio cholera. PLoS Genet. 2017 May 26;13(5):e1006826. doi: 10.1371/journal.pgen.1006826.

Kalia VC, Raju SC, Purohit HJ. Genomic analysis reveals versatile organisms for quorum quenching enzymes: acyl-homoserine lactone-acylase and -lactonase. Open Microbiol J. 2011;5:1-13. doi: 10.2174/1874285801105010001.

Kusada H, Tamaki H, Kamagata Y, Hanada S, Kimura N. A novel quorum-quenching enzyme mediates antibiotic resistance. Appl Environ Microbiol. 2017 Jun 16;83(13). pii: e00080-17. doi: 10.1128/AEM.00080-17.

Lade H, Paul D, Kweon JH. Quorum quenching mediated approaches for control of membrane biofouling. Int J Biol Sci. 2014 May 14;10(5):550-65. doi: 10.7150/ijbs.9028.

Lord DM, Baran AU, Wood TK, Peti W, Page R. BdcA, a protein important for Escherichia coli biofilm dispersal, is a short-chain dehydrogenase/reductase that binds specifically to NADPH. PLoS One. 2014 Sep 22;9(9):e105751. doi: 10.1371/journal.pone.0105751.

Mukherji R, Prabhune A. A new class of bacterial quorum sensing antagonists: glycomonoterpenols synthesized using linalool and alpha terpineol. World J Microbiol Biotechnol. 2015 Jun;31(6):841-9. doi: 10.1007/s11274-015-1822-5.

Papenfort K, Bassler BL. Quorum sensing signal-response systems in Gram-negative bacteria. Nat Rev Microbiol. 2016 Aug 11;14(9):576-88. doi: 10.1038/nrmicro.2016.89.

Park JS, Ryu EJ, Li L, Choi BK, Kim BM. New bicyclic brominated furanones as potent autoinducer-2 quorum-sensing inhibitors against bacterial biofilm formation. Eur J Med Chem. 2017 Sep 8;137:76-87. doi: 10.1016/j.ejmech.2017.05.037.

Parveen N, Cornell KA. Methylthioadenosine/S-adenosylhomocysteine nucleosidase, a critical enzyme for bacterial metabolism. Mol Microbiol. 2011 Jan;79(1):7-20. doi: 10.1111/j.1365-2958.2010.07455.x.

Passos da Silva D, Schofield MC, Parsek MR, Tseng BS. An Update on the Sociomicrobiology of Quorum Sensing in Gram-Negative Biofilm Development. Pathogens. 2017 Oct 21;6(4). pii: E51. doi: 10.3390/pathogens6040051.

Singh RP. Attenuation of quorum sensing-mediated virulence in Gram-negative pathogenic bacteria: implications for the post-antibiotic era. Med. Chem. Commun. 2015;(6):259-272. doi: 10.1039/C4MD00363B.

Vega LM, Mathieua J, Yang Y. Nickel and cadmium ions inhibit quorum sensing and biofilm formation without affecting viability in Burkholderia multivorans. Int Biodeter Biodegr. 2014;91:82-87. doi: 10.1016/j.ibiod.2014.03.013.

Weiland-Bräuer N, Kisch MJ, Pinnow N, Liese A, Schmitz RA. Highly Effective Inhibition of Biofilm Formation by the First Metagenome-Derived AI-2 Quenching Enzyme. Front Microbiol. 2016 Jul 13;7:1098. doi: 10.3389/fmicb.2016.01098.

Welsh MA, Blackwell HE. Chemical probes of quorum sensing: from compound development to biological discovery. FEMS Microbiol Rev. 2016 Sep;40(5):774-94. doi: 10.1093/femsre/fuw009.

Whiteley M, Diggle SP, Greenberg EP. Progress in and promise of bacterial quorum sensing research. Nature. 2018 Feb 28;555(7694):126. doi: 10.1038/nature25977.

Zhao J, Chen M, Quan CS, Fan SD. Mechanisms of quorum sensing and strategies for quorum sensing disruption in aquaculture pathogens. J Fish Dis. 2015 Sep;38(9):771-86. doi: 10.1111/jfd.12299.

Copyright (c) 2020 CHILD`S HEALTH

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.


© Publishing House Zaslavsky, 1997-2020


   Seo анализ сайта