Drug management of oxidation-reduction state of the body in respiratory tract diseases (part 5)

A.E. Abaturov, A.P. Volosovets, T.P. Borysova


The review of the literature presents modern data on antioxidant activity and immunomodulatory action of vitamin A in diseases of the respiratory system.


diseases of the respiratory system; antioxidant system; drug management; review


Abaturov AE, Volosovets AP, Borysova TP. Drug management of oxidation-reduction state of the body in respiratory tract diseases (part 4). Zdorov`e rebenka. 2018;13(6):616-620. doi: 10.22141/2224-0551.13.5.2018.143169. (in Russian).

Savchenko AA, Anisimova EN, Borisov AG, Kondakov AE. Vitaminy kak osnova immunometabolicheskoi terapii [Vitamins as the basis of immunometabolic therapy]. Krasnoyarsk: Publishing house KrasSMU; 2011. 213 p. (in Russian).

Strumilo SA, Kanunnikova NP. Mechanisms for the rapid regulation of the activity of the pyruvate dehydrogenase complex in mammals. Vesnik Grodzenskaga dzarzaunaga universiteta ima Anki Kupaly: Serya 2. 2010; 96(2):146-152. (in Russian).

Allen S, Britton JR, Leonardi-Bee JA. Association between antioxidant vitamins and asthma outcome measures: systematic review and meta-analysis. Thorax. 2009 Jul;64(7):610-9. doi: 10.1136/thx.2008.101469.

Linderholm AL, Onitsuka J, Xu C, Chiu M, Lee WM, Harper RW. All-trans retinoic acid mediates DUOX2 expression and function in respiratory tract epithelium. Am J Physiol Lung Cell Mol Physiol. 2010 Aug;299(2):L215-21. doi: 10.1152/ajplung.00015.2010.

Al Senaidy AM. Serum vitamin A and beta-carotene levels in children with asthma. J Asthma. 2009 Sep;46(7):699-702. doi: 10.1080/02770900903056195.

Balmer JE, Blomhoff R. Gene expression regulation by retinoic acid. J Lipid Res. 2002 Nov;43(11):1773-808.

Bastien J, Rochette-Egly C. Nuclear retinoid receptors and the transcription of retinoid-target genes. Gene. 2004 Mar 17;328:1-16. doi:10.1016/j.gene.2003.12.005.

Benn CS. Combining vitamin A and vaccines: convenience or conflict? Dan Med J. 2012 Jan;59(1):B4378.

Bendich A. From 1989 to 2001: what have we learned about the "biological actions of beta-carotene"? J Nutr. 2004 Jan;134(1):225S-230S. doi:10.1093/jn/134.1.225S.

Berbis P. Retinoids: mechanisms of action. Ann Dermatol Venereol. 2010 Nov;137 Suppl 3:S97-103. doi: 10.1016/S0151-9638(10)70036-3. (in French).

Berdanier C. Advanced Nutrition Micronutrients. CRC Press; 1997. 256 р.

Böhm F, Edge R, Truscott TG. Interactions of dietary carotenoids with singlet oxygen (1O2) and free radicals: potential effects for human health. Acta Biochim Pol. 2012;59(1):27-30.

Camoretti-Mercado B. Targeting the airway smooth muscle for asthma treatment. Transl Res. 2009 Oct;154(4):165-74. doi: 10.1016/j.trsl.2009.06.008.

Shi Q, Cao H, Liu J, et al. CD4+ Foxp3+ regulatory T cells induced by TGF-β, IL-2 and all-trans retinoic acid attenuate obliterative bronchiolitis in rat trachea transplantation. Int Immunopharmacol. 2011 Nov;11(11):1887-94. doi: 10.1016/j.intimp.2011.07.020.

Chew BP, Park JS. Carotenoid action on the immune response. J Nutr. 2004 Jan;134(1):257S-261S. doi:10.1093/jn/134.1.257S.

Clagett-Dame M, Knutson D. Vitamin A in reproduction and development. Nutrients. 2011 Apr;3(4):385-428. doi: 10.3390/nu3040385.

Clugston RD, Blaner WS. Vitamin A (retinoid) metabolism and actions: What we know and what we need to know about amphibians. Zoo Biol. 2014 Nov-Dec;33(6):527-35. doi: 10.1002/zoo.21140.

Catalano A, Simone RE, Cittadini A, Reynaud E, Caris-Veyrat C, Palozza P. Comparative antioxidant effects of lycopene, apo-10'-lycopenoic acid and apo-14'-lycopenoic acid in human macrophages exposed to H2O2 and cigarette smoke extract. Food Chem Toxicol. 2013 Jan;51:71-9. doi: 10.1016/j.fct.2012.08.050.

D'Ambrosio DN, Clugston RD, Blaner WS. Vitamin A metabolism: an update. Nutrients. 2011 Jan;3(1):63-103. doi: 10.3390/nu3010063.

del Rio ML, Bernhardt G, Rodriguez-Barbosa JI, Förster R. Development and functional specialization of CD103+dendritic cells. Immunol Rev. 2010 Mar;234(1):268-81. doi: 10.1111/j.0105-2896.2009.00874.x.

Edge R, McGarvey DJ, Truscott TG. The carotenoids as anti-oxidants--a review. J Photochem Photobiol B. 1997 Dec;41(3):189-200.

Aung HH, Vasu VT, Valacchi G, et al. Effects of dietary carotenoids on mouse lung genomic profiles and their modulatory effects on short-term cigarette smoke exposures. Genes Nutr. 2009 Mar;4(1):23-39. doi: 10.1007/s12263-008-0108-z.

Gao F, Kinnula VL, Myllärniemi M, Oury TD. Extracellular superoxide dismutase in pulmonary fibrosis. Antioxid Redox Signal. 2008 Feb;10(2):343-54. doi:10.1089/ars.2007.1908.

Fassett RG, Coombes JS. Astaxanthin in cardiovascular health and disease. Molecules. 2012 Feb 20;17(2):2030-48. doi: 10.3390/molecules17022030.

Lalevée S, Anno YN, Chatagnon A, et al. Genome-wide in silico identification of new conserved and functional retinoic acid receptor response elements (direct repeats separated by 5 bp). J Biol Chem. 2011 Sep 23;286(38):33322-34. doi: 10.1074/jbc.M111.263681.

Gudas LJ, Wagner JA. Retinoids regulate stem cell differentiation. J Cell Physiol. 2011 Feb;226(2):322-30. doi: 10.1002/jcp.22417.

Haczku A. The dendritic cell niche in chronic obstructive pulmonary disease. Respir Res. 2012 Sep 19;13:80. doi: 10.1186/1465-9921-13-80.

Hoyos B, Acin-Perez R, Fischman DA, Manfredi G, Hammerling U. Hiding in plain sight: uncovering a new function of vitamin A in redox signaling. Biochim Biophys Acta. 2012 Jan;1821(1):241-7. doi: 10.1016/j.bbalip.2011.06.014.

Hill GE, Johnson JD. The vitamin A-redox hypothesis: a biochemical basis for honest signaling via carotenoid pigmentation. Am Nat. 2012 Nov;180(5):E127-50. doi: 10.1086/667861.

Mahmoud FF, Haines D, Al-Awadhi R, et al. In vitro suppression of lymphocyte activation in patients with seasonal allergic rhinitis and pollen-related asthma by cetirizine or azelastine in combination with ginkgolide B or astaxanthin. Acta Physiol Hung. 2012 Jun;99(2):173-84. doi: 10.1556/APhysiol.99.2012.2.11.

Kidd P. Astaxanthin, cell membrane nutrient with diverse clinical benefits and anti-aging potential. Altern Med Rev. 2011 Dec;16(4):355-64.

Kim CH. Roles of retinoic acid in induction of immunity and immune tolerance. Endocr Metab Immune Disord Drug Targets. 2008 Dec;8(4):289-94.

Naito T, Suda T, Suzuki K, et al. Lung dendritic cells have a potent capability to induce production of immunoglobulin A. Am J Respir Cell Mol Biol. 2008 Feb;38(2):161-7. doi:10.1165/rcmb.2007-0237OC.

Palozza P, Catalano A, Simone R, Cittadini A. Lycopene as a guardian of redox signalling. Acta Biochim Pol. 2012;59(1):21-5.

Simone RE, Russo M, Catalano A, et al. Lycopene inhibits NF-kB-mediated IL-8 expression and changes redox and PPARγ signalling in cigarette smoke-stimulated macrophages. PLoS One. 2011;6(5):e19652. doi: 10.1371/journal.pone.0019652.

Manicassamy S, Pulendran B. Retinoic acid-dependent regulation of immune responses by dendritic cells and macrophages. Semin Immunol. 2009 Feb;21(1):22-7. doi: 10.1016/j.smim.2008.07.007.

Massaro D, Massaro GD. Retinoids, alveolus formation, and alveolar deficiency: clinical implications. Am J Respir Cell Mol Biol. 2003 Mar;28(3):271-4. doi:10.1165/rcmb.F263.

Suzuki Y, Suda T, Furuhashi K, et al. Mouse CD11bhigh lung dendritic cells have more potent capability to induce IgA than CD103+ lung dendritic cells in vitro. Am J Respir Cell Mol Biol. 2012 Jun;46(6):773-80. doi: 10.1165/rcmb.2011-0329OC.

Villablanca EJ, Wang S, de Calisto J, et al. MyD88 and retinoic acid signaling pathways interact to modulate gastrointestinal activities of dendritic cells. Gastroenterology. 2011 Jul;141(1):176-85. doi: 10.1053/j.gastro.2011.04.010.

Pashkow FJ, Watumull DG, Campbell CL. Astaxanthin: a novel potential treatment for oxidative stress and inflammation in cardiovascular disease. Am J Cardiol. 2008 May 22;101(10A):58D-68D. doi: 10.1016/j.amjcard.2008.02.010.

Acin-Perez R, Hoyos B, Gong J, et al. Regulation of intermediary metabolism by the PKCdelta signalosome in mitochondria. FASEB J. 2010 Dec;24(12):5033-42. doi: 10.1096/fj.10-166934.

Pridgeon C, Bugeon L, Donnelly L, et al. Regulation of IL-17 in chronic inflammation in the human lung. Clin Sci (Lond). 2011 Jun;120(12):515-24. doi: 10.1042/CS20100417.

Iwata M, Hirakiyama A, Eshima Y, Kagechika H, Kato C, Song SY. Retinoic acid imprints gut-homing specificity on T cells. Immunity. 2004 Oct;21(4):527-38. doi: 10.1016/j.immuni.2004.08.011.

Day RM, Lee YH, Park AM, Suzuki YJ. Retinoic acid inhibits airway smooth muscle cell migration. Am J Respir Cell Mol Biol. 2006 Jun;34(6):695-703. doi: 10.1165/rcmb.2005-0306OC.

Montrone M, Martorelli D, Rosato A, Dolcetti R. Retinoids as critical modulators of immune functions: new therapeutic perspectives for old compounds. Endocr Metab Immune Disord Drug Targets. 2009 Jun;9(2):113-31.

Rhinn M, Dollé P. Retinoic acid signalling during development. Development. 2012 Mar;139(5):843-58. doi: 10.1242/dev.065938.

Rochette-Egly C, Germain P. Dynamic and combinatorial control of gene expression by nuclear retinoic acid receptors (RARs). Nucl Recept Signal. 2009 May 8;7:e005. doi: 10.1621/nrs.07005.

Guénégou A, Leynaert B, Pin I, Le Moël G, Zureik M, Neukirch F. Serum carotenoids, vitamins A and E, and 8 year lung function decline in a general population. Thorax. 2006 Apr;61(4):320-6. doi: 10.1136/thx.2005.047373.

Thyagarajan B, A Meyer K, Smith LJ, et al. Serum carotenoid concentrations predict lung function evolution in young adults: the Coronary Artery Risk Development in Young Adults (CARDIA) study. Am J Clin Nutr. 2011 Nov;94(5):1211-8. doi: 10.3945/ajcn.111.019067.

Sommer A, Vyas KS. A global clinical view on vitamin A and carotenoids. Am J Clin Nutr. 2012 Nov;96(5):1204S-6S. doi: 10.3945/ajcn.112.034868.

Checkley W, West KP Jr, Wise RA, et al. Supplementation with vitamin A early in life and subsequent risk of asthma. Eur Respir J. 2011 Dec;38(6):1310-9. doi: 10.1183/09031936.00006911.

Takaichi S. Carotenoids in algae: distributions, biosyntheses and functions. Mar Drugs. 2011;9(6):1101-18. doi: 10.3390/md9061101.

Palozza P, Parrone N, Catalano A, Simone R. Tomato Lycopene and Inflammatory Cascade: Basic Interactions and Clinical Implications. Curr Med Chem. 2010;17(23):2547-63.

Joo YE, Karrasch T, Mühlbauer M, et al. Tomato lycopene extract prevents lipopolysaccharide-induced NF-kappaB signaling but worsens dextran sulfate sodium-induced colitis in NF-kappaBEGFP mice. PLoS One. 2009;4(2):e4562. doi: 10.1371/journal.pone.0004562.

Tsiligianni IG, van der Molen T. A systematic review of the role of vitamin insufficiencies and supplementation in COPD. Respir Res. 2010 Dec 6;11:171. doi: 10.1186/1465-9921-11-171.

Wolf G. A history of vitamin A and retinoids. FASEB J. 1996 Jul;10(9):1102-7.

Wu L, Ross AC. Inflammation induced by lipopolysaccharide does not prevent the vitamin A and retinoic acid-induced increase in retinyl ester formation in neonatal rat lungs. Br J Nutr. 2013 May 28;109(10):1739-45. doi: 10.1017/S0007114512003790.

Yamazaki S, Steinman RM. Dendritic cells as controllers of antigen-specific Foxp3+ regulatory T cells. J Dermatol Sci. 2009 May;54(2):69-75. doi: 10.1016/j.jdermsci.2009.02.001.

Zhao J, Lloyd CM, Noble A. Th17 responses in chronic allergic airway inflammation abrogate regulatory T-cell-mediated tolerance and contribute to airway remodeling. Mucosal Immunol. 2013 Mar;6(2):335-46. doi: 10.1038/mi.2012.76.

Ziouzenkova O, Plutzky J. Retinoid metabolism and nuclear receptor responses: New insights into coordinated regulation of the PPAR-RXR complex. FEBS Lett. 2008 Jan 9;582(1):32-8. doi:10.1016/j.febslet.2007.11.081.

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